Edis ÇOLAK, Behzat ÖZKAN, Burak POLAT, Sinan GENÇ

Sağlıklı Türk İnfant, Çocukluk ve Adolesan Yaş Grubunda Tiroid İstmus Kalınlığının Ultrasonografik Ölçümü

Amaç: Tiroid bez hacmi için referans aralıklarının oluşturulması dünya çapında bir trend olmasına rağmen bugüne kadar sağlıklı çocuklarda tiroid istmus kalınlığı (TİK) ile ilgili sınırlı veri mevcuttur. Bu çalışmanın amacı 0-18 yaş arası Türk çocuklarda TİK'nın referans değerlerini belirlemektir. Gereç ve Yöntem: Aralık 2018 - Eylül 2020 tarihleri arasında 447 kişide TİK ultrasonografi ile ölçüldü. TİK için 3., 10., 25., 50., 75. ve 95. persentil değerleri yaş ve cinsiyete göre hesaplandı ve yayınlanan verilerle karşılaştırıldı. TİK değerleri, çocukların yaş, cinsiyet ve ağırlık, boy, vücut kitle indeksi (VKİ) Z-skorları ile karşılaştırıldı. Bulgular: TİK medyan [çeyrekler arası aralık (IQR) 25 - 75] değerleri 1.5 (1.3-2.0) mm idi. Tiroid istmus kadınlarda erkeklere göre daha kalındı ve bu cinsiyet farkı istatistiksel açıdan anlamlıydı (sırasıyla 1.6mm, 1.5mm ve p=0.023). TİK ve yaş, ağırlık, boy, VKİ Z-skor değerleri arasında belirgin fark gözlendi (sırasıyla r=0.461, r=0.457, r=0.448 ve r=0.434; p

Anahtar Kelimeler:

Tiroid istmus, tiroid istmus kalınlığı, ultrason

Ultrasonographic Measurement of the Thyroid Isthmus Thickness in Healthy Turkish Infants, Children, and Adolescents

Aim: The importance of establishing reference ranges for thyroid volume is a worldwide trend, however, to date, limited data are available regarding thyroid isthmus thickness (TIT) in healthy children. The present study aimed to report the reference values for TIT in children aged between 0 and 18 years from Turkey. Material and Method: The TIT was measured by ultrasonography in 447 subjects between December 2018 and September 2020. The 3rd, 10th, 25th, 50th, 75th, and 95th percentiles of the TIT according to age and gender were determined and compared with published data. The TIT values were compared with children’s age, gender, and Z-score data for weight, height, and body mass index (BMI). Results: The median [interquartile range (IQR) 25 - 75] values for TIT were 1.5 (1.3-2.0) mm. The TI was thicker in females than in males and this gender difference was statistically significant (1.6mm vs. 1.5mm, p=0.023, respectively). The TIT was highly significantly associated with age, and Z-scores for weight, height, and BMI (r=0.461, r=0.457, r=0.448, and r=0.434, respectively; p

Keywords:

Thyroid isthmus, thyroid isthmus thickness, ultrasound,

PDF

___

1. Babcock DS. Thyroid disease in the pediatric patient: emphasizing imaging with sonography. Pediatr Radiol 2006;36:299-308.
2. Nilsson M, Fagman H. Development of the thyroid gland. Development. 2017;15:2123-2140.
3. Alexander LF, Patel NJ, Caserta MP, Robbin ML. Thyroid Ultrasound: Diffuse and Nodular Disease. Radiol Clin North Am. 2020;58:1041-10574.
4. Kosiak W, Swięton D, Piskunowicz M, Kujawa M. Thyroid isthmus thickness in prepubertal healthy children in an iodine-sufficient region. Pol J Radiol 2010;75:17-19.
5. Çolak E. Ultrasonographic Evaluation of the Pyramidal Lobe of the Thyroid Gland in Infants and Children in Western Turkey Between 2018 and 2020, Iran J Radiol. 2021;18: e108543
6. Ramo Akgün N, (2021). Assistive Technology for Children with Intellectual Disabilities. In İşcan, A., Baskın, S (Ed.), Recent Studies of Education in Various Occasions. Mauritius: Lambert Academic Publishing, 26-51.
7. Neyzi O, Bundak R, Gökçay G, et al. Reference Values for Weight, Height, Head Circumference, and Body Mass Index in Turkish Children. J Clin Res Pediatr Endocrinol 2015;7:280-293.
8. Kyritsi EM, Kanaka-Gantenbein C. Autoimmune Thyroid Disease in Specific Genetic Syndromes in Childhood and Adolescence. Front Endocrinol (Lausanne). 2020;11:543.
9. Zimmermann MB, Molinari L, Spehl M, et al. Toward a consensus on reference values for thyroid volume in iodine-replete schoolchildren: results of a workshop on inter-observer and inter-equipment variation in sonographic measurement of thyroid volume. Eur J Endocrinol. 2001;144:213-220.
10. Zimmermann MB, Hess SY, Molinari L, et al. New reference values for thyroid volume by ultrasound in iodine-sufficient schoolchildren: a World Health Organization/Nutrition for Health and Development Iodine Deficiency Study Group Report. Am J Clin Nutr. 2004;79:231-237.
11. Çolak E, Özkan B, Genç S, Poalt B. Ultrasonographic determination of thyroid volume in infants and children from Aegean region of Turkey and comparison with national and international references. J Pediatr Endocrinol Metab. 2021;34:457-464.
12. Kayastha P, Paudel S, Ghimire RK. Ultrasound measurement of thyroid isthmus thickness in clinically euthyroid subjects. Nepalese Journal of Radiology 2018;8:26-29.
13. Seker S, Tas I. Determination of Thyroid Volume and Its Relation with Isthmus Thickness. Eur J Gen Med 2010;7:125-129.
14. Won HS, Han SH, Oh CS, Chung IH, Won HJ, Kim JH. Location and morphometry of the thyroid isthmus in adult Korean cadavers. Anat Sci Int 2013;88:212-216.
15. Sultana SZ, Khalil M, Khan MK, et al. Morphometry of isthmus of thyroid gland in Bangladeshi cadaver. Mymensingh Med J 2011;20:366-370.