Ayhan ATIGAN, Yeliz ARMAN KARAKAYA, İbrahim Veysel FENKCİ, Ümit ÇABUŞ

Overin atipik proliferatif (Borderline) Brenner tümörü

Brenner tümörleri overin nadir görülen transizyonel hücreli tümörleridir. Genellikle benign tümörlerdir ancak daha ender olarak borderline ve malign tipleri de vardır. Benign Brenner tümörlerinin çoğu küçüktür ve rastlantısal olarak bulunur. Olgumuz sol over kisti nedeni ile laparotomi yapılan 57 yaşında kadın hastadır. Sol overdeki kitle eksize edildi ve histopatolojik incelemede borderline (atipik proliferatif) Brenner tümörü tanısı konuldu. Yazımızda bu nadir olgunun histopatolojik bulguları sunularak literatür gözden geçirilmektedir.

Anahtar Kelimeler:

Brenner tümörü, over, borderline, atipik proliferatif

Ovarian atypical proliferative (Borderline) Brenner tumor

Brenner tumors are rare transitional cell tumors of the ovary. They are usually benign tumors but rarely have borderline and malignant types. Most of the benign Brenner tumors are small and are found incidentally. Our case was a 57 years old woman who underwent laparotomy for ovarian cyst. On laparotomy a solid mass was found on the left ovary. The left ovarian mass was excised and a histopathological diagnosis of borderline (atypical proliferative) Brenner tumor was made. In this paper, histopathological findings of this rare case are presented and the literature is reviewed.

Keywords:

Brenner tumor, ovary, borderline, atypical proliferative,

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1-Aslan F, Paksoy S, Altun E. Overin bening brenner tümörü: Rastlantısal bir tanı. Balıkesir Medical Journal 2017;1:9-14.
2-Zheng R, Heller DS. Borderline Brenner tumor: A review of the literature. Arch Pathol Lab Med 2019;143:1278-1280. doi: 10.5858/arpa.2018-0285-RS
3- Vemavarapu L,Alatassi H,Moghadamfalahi M. Unusual presentation of benign cystic Brenner tumor with exuberant psammomatous calcifications. International Journal of Surgical Pathology 2011;19:120-122.
4-Ayık H, Bayramoğlu, Z, Aydin A, Pestereli H, Şimşek T. Borderline Brenner tumor with a concomitant mucinous tumor of the ovary: a case report. Eur Res J 2018;4:122-125. doi:10.18621/eurj.357653
5- Roth LM, Sternberg WH. Proliferating Brenner tumors. Cancer 1971;27:687-698.
6- Roma AA, Masand RP. Different staining patterns of ovarian Brenner tumor and the associated mucinous tumor. Ann Diagn Pathol. 2015;19:29-32. doi: 10.1016/j.anndiagpath.2014.12.002
7- Santini D, Gelli MC, Mazzoleni G, et al. Brenner tumor of the ovary: a correlative histologic, histochemical, immunohistochemical, and ultrastructural investigation. Hum Pathol 1989,20:787-795.
8- Ruggiero S, Ripetti V, Bianchi A, et al. A singular observation of a giant benign Brenner tumor of the ovary. Arch Gynecol Obstet 2011;284:513-516.doi: 10.1007/s00404-011-1930-x
9- Kuhn E, Ayhan A, Shihle M, Seidman JD, Kurman RJ. The pathogenesis of atypical proliferative Brenner tumor: an immunohistochemical and molecular genetic analysis. Mod Pathol 2014;27:231-237. doi: 10.1038/modpathol.2013.142
10- Ashok V, Chander B, Verma S , Soni A. Malignant Brenner tumor of ovary. J Obstet Gynaecol India 2014;64:148-149.doi: 10.1007/s13224-012-0235-8