Akut romatizmal ateş tedavisinde aspirine bağlı hepatotoksisitenin değerlendirilmesi

Amaç: Akut romatizmal ateş (ARA) tedavisinde artrit veya hafif kardit tablosunda ilk tercih edilen ilaç aspirindir ve aspirine bağlı hepatotoksisite sık görülmesine karşın, bu konu ile ilgili az sayıda güncel çalışma vardır. Bu çalışmada, ARA tanısı ile aspirin tedavisi alan çocuklarda hepatotoksisite sıklığı, etki eden faktörlerin araştırılması amaçlanmıştır. Gereç ve yöntem: Ocak 2008 ile Haziran 2019 arasında akut atak ARA tanısı ile aspirin tedavisi verilen toplam 133 çocuk retrospektif olarak değerlendirildi. Hastalar, hepatotoksisite gelişen ve hepatotoksisite gelişmeyen olmak üzere iki gruba ayrıldı. Aspirin ile ilişkili hepatotoksisite gelişimine etki edebilecek demografik, klinik ve laboratuvar parametreleri analiz edildi. Bulgular: Toplam 133 hastanın 50'sinde (%37,6) aspirine bağlı hepatotoksisite gelişmişti. Hepatotoksisite gelişen ve gelişmeyen grupların yaş ortalamaları, erkek/kız oranları ve aspirin dozları benzerdi (p>0,05). Hepatotoksisite gelişen grupta yedinci, on beşinci ve yirmi sekizinci günlerde bakılan AST ve ALT düzeyleri anlamlı olarak yüksekti (p

Evaluation of aspirin-induced hepatotoxicity in the treatment of acute rheumatic fever

Purpose: Aspirin is the first choice drug in the treatment of arthritis or mild carditis in the acute rheumatic fever (ARF). Although aspirin-induced hepatotoxicity is common, there are few studies on this issue. The aim of this study was to investigate the incidence of hepatotoxicity and the factors that affect hepatotoxicity in children who were diagnosed ARF and received aspirin treatment. Materials and methods: Between January 2008 and June 2019, total 133 children with acute attack ARF who were treated with aspirin were retrospectively evaluated. Patients were divided into two groups as with hepatotoxicity and non-hepatotoxicity. Demographic, clinical and laboratory parameters that may affect the development of aspirin-induced hepatotoxicity were analyzed. Results: Aspirin-induced hepatotoxicity developed in 50 (37.6%) patients. The mean age, male/female ratio and doses of aspirin used in the groups were similar (p>0.05).Liver enzymes levels were significantly higher in the hepatotoxicity group at 7th, 15th and 28th days (p

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