Mevcut Küresel Koronavirüs Tehdidinin (Covid-19) İmmün Sorumlulukları Hakkında Genel Bir Değerlendirme

Covid-19 SARS-CoV-2 (şiddetli akut solunum sendromu-koronavirüs-2), bulaşıcı bir üst solunum yolu enfeksiyonu hastalığı olarak bilinen yeni bir koronavirüs türüdür. Dünya genelinde insan sağlığı için büyük bir tehdit oluşturan koronavirüs, Aralık 2019'da Çin'in Wuhan kentinde ortaya çıkmıştır. Koronavirüs salgınlarının pandemi haline gelmesinin en önemli nedeni, hastalığın enfekte kişilerin yakınında bulunan damlacıklar yoluyla kolayca bulaşmasıdır. Birkaç ay içinde hızla tüm dünyaya yayılan hastalık, Mart 2020'de Dünya Sağlık Örgütü tarafından dünya çapında bir salgın olarak ilan edilmiştir. İleri yaş grubunda hipertansiyon, diyabet, kardiyovasküler hastalık, kanser, kronik akciğer hastalığı ve kronik böbrek hastalığı gibi ağır hastalık tablosu için risk oluşturmaktadır. Bugüne kadar ölüm oranları göz önüne alındığında, Covid-19 enfeksiyonuna karşı başarılı ilaçlar ve aşılar üretmek için hem dünya çapında hem de ülkemizde büyük çabalar sarf edilmektedir. Bu derlemenin temel amacı, insanlığı derinden etkileyen koronavirüs salgını ve neden olduğu hastalıklar hakkında elde edilen mevcut bilgiler sayesinde Covid-19 için bir bağışıklık müdahalesine ve önleyici çalışmalara yardımcı olmaktır.

Anahtar Kelimeler:

Covid-19, ACE2 reseptörü, Coronavirüs, Spike proteini, Aşı tedavisi

A General Evaluation on Current Global Threat of Coronavirus (Covid-19) Immuno Responsibilities

Covid-19 SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2) is a new type of coronavirus known as an infectious upper respiratory tract infection disease. The coronavirus, which poses a great threat to human health worldwide, emerged in Wuhan, China in December 2019. The most important reason for coronavirus epidemics to become a pandemic that the disease was easily transmitted by droplets in close proximity with infected people. The disease spread rapidly all over the world within a few months and it was declared a worldwide epidemic by the World Health Organization in March 2020. It poses a risk for severe diseases such as hypertension, diabetes, cardiovascular disease, cancer, chronic lung disease and chronic kidney disease in the advanced age group. Considering the mortality rates to date, great efforts have been made both worldwide and in our country to manifacture successful drugs and vaccines against Covid-19 infection. The main purpose of this review is to assist in an immune response and preventive work for Covid-19, thanks to the available information about the coronavirus epidemic that deeply affects humanity and the diseases it causes.

Keywords:

ACE2 reseptor, Coronavirus, Covid-19, Spike protein, Treatment vaccine,

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