CUMA MERTOĞLU, Murat GUNAY, Saleh MAHARRAMOW

The Effects of Increased Humidity and Weather Conditions on Inflammatory and Oxidative Stress Markers in Healthy Rats

Although it is known that the symptoms of rheumatoid arthritis patients increase in cold, humid and rainy days but its mechanism is unclear. It was aimed to investigate the effects on some inflammatory and oxidative stress markers in different weather conditions in rats. Some inflammatory, oxidant and antioxidant markers were measured in sera of healthy rats in sunny, cloudy and rainy days. The levels of reduced glutathione (GSH) and glutathione reductase (GR) were found to be lower in both cloudy and rainy days with respect to sunny days (p = 0.001 and 0.004 respectively). Similarly, α -glutathione-S-transferase levels were found to be lower on rainy days than on sunny days (p = 0.017). Malondialdehyde (MDA) was found to be higher (p = 0.044) in rainy days compared to sunny days. Nitric oxide (NO) and interleukin-1β (IL-1β) were found to be higher in cloudy and rainy days compared to sunny days (p = 0.003 and 0.025, respectively). The findings indicate that oxidative stress-related inflammation is triggered in rainy and cloudy days.

Nem ve Hava Koşullarının Subklinik I nflamasyon ve Oksidatif Stres Markırları Ü zerine Etikileri

Romatoid artritli hastaların semptomlarının soğuk, nemli ve yağmurlu günlerde arttığı bilinmekle birlikte, mekanizması açık değildir. Bu çalışmada, farklı hava koşullarında, bazı inflamatuar ve oksidatif stres markırlarının üzerine etkilerinin araştırılması hedeflenmiştir. Bazı inflamatuar, oksidan ve antioksidan markırların düzeyleri, güneşli, bulutlu ve yağmurlu günlerde sağlıklı ratların serumunda ölçüldü. Glutatyon redüktaz (GR) ve indirgenmiş glutatyon hem bulutlu hem de yağmurlu günlerde, güneşli güne kıyasla daha düşük olarak bulundu (p = 0.001 ve 0.004 sırasıyla). α – glutatyon-S-transferaz yağmurlu günde güneşli güne kıyasla daha düşük olduğu bulundu (p = 0.017). Malondialdehit (MDA) yağmurlu günde güneşli güne kıyasla daha yüksek olarak bulunmuştur (p = 0.044). Nitrik oksit ve interlökin-1 β (IL-1β) bulutlu ve yağmurlu günde güneşli güne kıyasla daha yüksek bulunmuştur (p = 0.003 ve 0.025, sırasıyla). Bulgular, yağmurlu ve bulutlu günlerde oksidatif stres ilişkili inflamasyonun tetiklendiğini göstermektedir.

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