FAHRETTİN AKYÜZ, Yakup KARA, FATİH KAR, CEYHAN HACIOĞLU, M. Cengiz ÜSTÜNER

Sigara Dumanına Maruz Kalan Sıçanlarda Lipit Profili ve Karaciğer Fonksiyon Testleri Üzerine L -NAME ve Vitamin E'nin Etkileri

Sigara milyonlarca insan tarafından kullanılmakta olup çevreye ve diğer canlılara doğrudan zarar verir. İçindeki binlerce zararlı madde nedeniyle farklı metabolizmalar üzerinden karaciğer, kalp ve akciğer gibi birçok organı tahrip eder. Bu çalışmada ticari sigaradan elde edilen sigara dumanına inhalasyon yoluyla maruz kalmadan kaynaklanan oksidatif stres sonucunda değişen bazı kan parametresi düzeylerinin Vitamin E ve L-NAME uygulaması ile değerlendirmesi amaçlanmıştır. Çalışmada, 45 erkek Wistar albino sıçan, her grupta 9 sıçan olmak üzere beş gruba ayrıldı. Sigara dumanı özel kafeslerde inhalasyon ile sağlanırken, 200 mg/kg vücut ağırlığı (VA) Vitamin E ve 50 mg/kg VA L-NAME intraperitoneal olarak 42 gün boyunca uygulandı. 43. günde, sıçanlardan kan örnekleri alındı. Kan örneklerinde uygun işlemlerden sonra alanin aminotransferaz (ALT), aspartat aminotransferaz (AST), trigliserit, yüksek yoğunluklu lipoprotein kolesterol (HDL-C), düşük yoğunluklu lipoprotein kolesterol (LDL-C) ve kolesterol düzeyleri incelendi. Sigara dumanı grubunda; ALT, AST, trigliserid, kolesterol ve LDL-C düzeylerinde kontrol grubuna göre anlamlı düzeyde artış gözlenirken (p

Effects of L-NAME and Vitamin E on Lipid Profile and Liver Function Tests in Rats Exposed to Cigarette Smoke

Cigarettes are used by millions of people and directly harm the environment and other living things. Because of the thousands of harmful substances in it, it destroys many organisms such as liver, heart and lung through different metabolisms. In this study, it was aimed to evaluate the levels of certain blood parameters that changed as a result of oxidative stress resulting from exposure to cigarette smoke from commercial cigaratte through inhalation with the application of Vitamin E and L-NAME. In the study, 45 male Wistar albino rats were divided into five group and each group had 9 rats. Cigaratte smoke was administered by inhalation in special cages, 200 mg/kg-BW Vitamin E and 50 mg/kg-BW L-NAME was administered by intraperitoneal during 42 days. On day 43, blood samples were taken from the rats. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), Triglyceride, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and cholesterol levels were examined in blood samples. In the cigaratte smoke group; It was observed significant increase in LDL-C, triglyceride, ALT, AST and total cholesterol levels(p

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