Filiz YAVAŞOĞLU, Çiğdem ÖZDEMİR, Yiğit ŞENOL, Hacer DEMİR, Meltem BAYKARA

Senkron ve Metakron Hematolojik ve Onkolojik Tümörlerin Tek Merkez Deneyimi

Dünyada kanser görülme sıklığı giderek artmaktadır. Kanser tedavisindeki gelişmelerle birlikte hastaların ortalama yaşam süreleri uzamakta ve sekonder malignitelerin görülme sıklığı artmaktadır. Yeni kurulan bir hematoloji merkezinde hematolojik malignitelere eşlik eden senkron / metakron maligniteleri retrospektif olarak inceledik.Veriler tıbbi kayıtlardan elde edildi.Hastaların demografik verileri, tedavileri ve genel sağ kalımları değerlendirildi. Hematolojik maligniteli 433 hastanın 28’i (%6) çalışmaya devam edildi. 12 hasta (%42,9) senkron, 16 (%57,1) hasta ise metakron hematolojik-onkolojik tümör tanısı almıştır. Hastaların 16’sı erkek, 12’si kadındı. Senkron tümörlerde en sık görülen hematolojik malignite non-hodgkın lenfoma (NHL), en sık görülen onkolojik maligniteler ise tiroid papiller kanseri ve kolon kanseri idi. Metakron tümörlerde en sık görülen maligniteler NHL ve meme kanseri idi. Metakron tümörlerin tanısı arasındaki medyan süre 49,5 aydı (8-192 ay). Senkron malignitesi olan hastalrın medyan sağkalımı 19 aydı (SE=12,19) )%95 CI 0-42,89), metakron maligniteleri olan hastaların medyan sağkalımı 22 aydı (SE=14,9= (%95 CI 0-49,44). Senkron ve metakron maligniteleri olan hastaların sağkalım eğrilerinin karşılaştırılmasında istatistiksel olarak anlanmlı fark saptanmadı (p=0,382). Hematolojik malignitelere eşlik eden onkolojik maligniteler nadir değildir. Senkron / metakron hematolojik maligniteler için standart bir tedavi yoktur. Senkron multipl malignite varlığında, malignitelerin her biri ayrı ayrı değerlendirilmelidir.

Anahtar Kelimeler:

Multipl primer tümörler, Senkronize tümörler, Hematolojik maligniteler

A Single-center Experience of Synchronous and Metachronous Hematologic and Oncologic Tumors

The incidence of cancer is increasing in the world. With the developments in cancer treatment, the life expectancy of patients is prolonged and the incidence of secondary malignancies is increasing. We retrospetively patients with syncronous / metachronous oncological malignancies accompanying hematological malignancies in a newly established hematology center. Data were obtained from the medical records. Demographic data, treatments and overall survival of the patients were evaluated. Twenty eight (6%) of 433 patients hematological malignancies were included in the study. 12 patients (42.9) were diagnosed with syncronous and 16 (57.1%) patients with metachronous hematologic-oncologic tumors. Sixteen of the patients were male,twelve were female. In syncronous tumors, the most common hematologic malignancy was Non-hodgkın lymphoma (NHL), while the most common oncologic malignancies were thyroid papillary cancer and colon cancer. In metachronous tumors, the most common malignancies were NHL and breast cancer. The median time between diagnosis of metachronous tumors was 49.5 months (8-192 months). The median survival of patients with syncronous malignancies was 19 months (SE=12.19) (95% CI 0-42.89), with metachronous malignancies was 22 months (SE=14.0) (95% CI 0-49.44). There was no statistically significant difference in the comparison of survival curves of patients with syncronous and metachronous malignancies (p=0.382). Oncological malignancies accompanying hematological malignancies are not uncommon. There is no standart treatment for syncronous / metachronous hematologic malignancies. In the presence of syncronous multipl malignancies should be evaluated individually.

Keywords:

Multipl primary neoplasms, Syncronous neoplasms, Hematologic malignancies,

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