Didem TURCAN, Funda CANAZ, Evrim YILMAZ, Sare KABUKÇUOĞLU, Melih VELİPAŞAOĞLU

Overin Sklerozan Stromal Tümörü / Sclerosing Stromal Tumor of the Ovary

Öz: Overin sklerozan stromal tümörü seks kord stromal tümörler kategorisinde yer alır ve bu gruptaki tümörlerin %2-6’sını oluşturur. Bu tümör, histolojik olarak hyalinize veya ödemli stromayla ayrılan hücreden zengin lobül benzeri yapılardan oluşur. Bu alanlar, iğsi hücreler ve oval-yuvarlak hücreler olmak üzere iki farklı hücre tipi içerir. Burada sklerozan stromal tümör tanısı almış üç olgu sunulmuştur. Amacımız overin sklerozan stromal tümörünü klinikopatolojik özellikleri ile sunmak ve ayırıcı tanıyı son literatür bilgilerini de gözden geçirerek tartışmaktır. Anahtar Kelimeler: over, over tümörleri, seks kord stromal tümörleri, immünohistokimyaAbstract: The sclerosing stromal tumor (SST) of the ovary belongs to sex cord-stromal tumors category and is accounted for 2-6 % of this group. Histologically, this tumor consists of cellular pseudolobules that were separated by hyalinized or oedematous stroma. These areas include two different cell types; spindle shaped and round to oval cells. Three cases diagnosed as sclerosing stromal tumor were presented in this article. Aim of this article is to present clinicopathologic features of SST and to discuss the differential diagnosis by reviewing the recent literature. Keywords: ovary, ovary neoplasms, sex cord-stromal tumor, immunohistochemistry

Anahtar Kelimeler:

over, over tümörleri, seks kord-gonadal tümörleri

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1. Zekioglu, O., Ozdemir, N., Terek, C., Ozsaran, A., & Dikmen, Y. (2010). Clinicopathological and immunohistochemical analysis of sclerosing stromal tumours of the ovary. Archives of gynecology and obstetrics, 282(6), 671-676.
2. Chalvardjian, A., & Scully, R. E. (1973). Sclerosing stromal tumors of the ovary. Cancer, 31(3), 664-670.
3. Kaygusuz, E. I., Cesur, S., Cetiner, H., Yavuz, H., & Koc, N. (2013). Sclerosing stromal tumour in young women: clinicopathologic and immunohistochemical spectrum. J Clin Diagn Res, 7(9), 1932-1935.
4. Khanna, M., Khanna, A., & Manjari, M. (2012). Sclerosing stromal tumor of ovary: a case report. Case reports in pathology, 2012.
5. Kim, T. H., Lee, H. H., Hong, J. A., Park, J., Jeon, D. S., Lee, A., & Koh, E. S. (2014). Sclerosing stromal tumor in an elderly postmenopausal woman. Journal of Menopausal Medicine, 20(2), 80-83.
6. Youm, H. S., Cha, D. S., Han, K. H., Park, E. Y., Hyon, N. N., & Chong, Y. (2008). A case of huge sclerosing stromal tumor of the ovary weighing 10 kg in a 71-year-old postmenopausal woman. Journal of gynecologic oncology, 19(4), 270-274.
7. Chaurasia, J., Afroz, N., Maheshwari, V., & Naim, M. (2014). Sclerosing stromal tumor of the ovary presenting as precocious puberty: Unusual presentation of the rare neoplasm. International Journal of Medicine and Public Health, 4(3), 307-307.
8. Peng, H. H., Chang, T. C., & Hsueh, S. (2003). Sclerosing stromal tumor of ovary. Chang Gung medical journal, 26(6), 444-448.
9. Akbulut, M., Colakoglu, N., Soysal, M. E., & Duzcan, S. E. (2004). Sclerosing stromal tumor of the ovary: report of a case and review of the literature. Aegean Pathol J, 1, 84-89.
10. Movahedi-Lankarani, S., & Kurman, R. J. (2002). Calretinin, a more sensitive but less specific marker than α-inhibin for ovarian sex cord-stromal neoplasms: an immunohistochemical study of 215 cases. The American journal of surgical pathology, 26(11), 1477-1483.
11. Kostopoulou, E., Moulla, A., Giakoustidis, D., & Leontsini, M. (2003). Sclerosing stromal tumors of the ovary: a clinicopathologic, immunohistochemical and cytogenetic analysis of three cases. European journal of gynaecological oncology, 25(2), 257-260.
12. Dilbaz, B., Tascı, Y., Ulular, Y., Demir, Ö. F., & Göktolga, Ü. (2011). Sclerosing Stromal Tumor of the ovary. J Turk Soc Obstet Gynecol, 8, 286-8.