Ziprasidon, Aripiprazol, Blonanserin, Siyamemazin ve Nemonaprid'in Farelerde İzole Detrusor Düz Kasına Kronik Etkileri

Amaç: Ziprasidon, aripiprazol, blonanserin, siyamemazin ve nemonaprid şizofreni tedavisinde kullanılan atipik antipsikotik ilaçlardır. Bu çalışmada bu atipik antipsikotik ilaçların organ banyosu kullanılarak farelerde izole edilmiş mesane üzerine etkilerinin belirlenmesi amaçlanmıştır.

Chronic Effects of Ziprasidone, Aripiprazole, Blonanserin, Cyamemazine, and Nemonapride on Mice Isolated Detrusor Smooth Muscle

Objective: Ziprasidone, aripiprazole, blonanserin, cyamemazine, and nemonapride are atypical antipsychotic drugs used for the treatment of schizophrenia. This study aimed to identify the effects of these atypical antipsychotic drugs in mice isolated bladder using the organ bath system

___

  • Abrams P, Cardozo L, Fall M, et al. The standardisation of terminology of lower urinary tract function: Report from the standardisation sub-committee of the International Continence Society. Neurourol Urodyn. 2003;61(1):37-49. doi:10.1016/s0090-4295(02)02243-4
  • Drake MJ. Do we need a new definition of the overactive bladder syndrome? ICI-RS 2013. Neurourol Urodyn. 2014;33(5):622-624. doi:10.1002/nau.22609
  • Chuang YC, Liu SP, Lee KS, et al. Prevalence of overactive bladder in China, Taiwanand South Korea: Results from a cross-sectional, population-based study. Low Urin Tract Symptoms. 2019;11(1): 48-55.
  • Sadananda P, Drake MJ, Paton JF, Pickering AE. A functional analysis of the influence of β 3-adrenoceptors on the rat micturition cycle. J Pharmacol Exp Ther. 2013;347(2):506-515. doi:10.1124/jpet.113.207340
  • Daly D, Chapple C. Relationship between overactive bladder (OAB) and irritable bowel syndrome (IBS): concurrent disorders with a common pathophysiology? BJU Int. 2013;111(4):530-531. doi:10.1111/j.1464-410X.2013.11019.x
  • Groat WC, Griffiths D, Yoshimura N. Neural control of the lower urinary tract. Compr Physiol. 2015;5(1): 327-396. doi:10.1002/cphy.c130056
  • Schmidt AW, Lebel LA, Howard HR Jr, Zorn SH. Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile. Eur J Pharmacol. 2001;425:197-201. doi:10.1016/s0014-2999(01)01188-8
  • Shapiro DA, Renock S, Arrington E, et al. Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology. Neuropsychopharmacology. 2003;28(8):1400-1411.
  • Bayazıt H, Kiliçaslan F. Diuarnal Enurisis Secondary to Aripiprazol. Mustafa Kemal Üniv Tıp Derg. 2017;8(31):36-38. doi:10.17944/mkutfd.376533
  • Kato K, Yamada K, Maehara M, et al. Blonanserin in the treatment of delirium. Psychiatry Clin. Neurosci. 2011;65:389-391. doi:10.1038/sj.npp.1300203
  • Min A, Kim D. Blonanserin-induced mood alteration in schizophrenia and schizoaffective disorder: two cases. Clin Psychopharmacol Neurosci. 2013;11(3):165-167. doi:10.9758/cpn.2013.11.3.165
  • Tata 1mg. https://www.1mg.com/generics/blonanserin-212560. Accessed March 3, 2003.
  • Arnt J, Skarsfeldt T. Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence. Neuropsychopharmacology. 1998;18:63-101. doi:10.1016/S0893-133X(97)00112-7
  • UK Gabapentin Study Group. Gabapentin in partial epilepsy. Lancet. 1990;335(8698):1114-1117.
  • Tanyeri MH, Buyukokuroglu ME, Tanyeri P, et al. Effects of long-term treatment with haloperidol, clozapine and aripiprazole on mice isolated vas deferens. Int Urol Nephrol. 2017;49(9):1561-1567.
  • Bourin M, Nic Dhonnchadha BA, Claude Colombel M, Dib M, Hascoët M. Cyamemazine as an anxiolytic drug on the elevated plus maze and light/dark paradigm in mice. Behav Brain Res. 2001;124(1):87-95.
  • Horiguchi M, Meltzer HY. Blonanserin reverses the phencyclidine (PCP)-induced impairment in novel object recognition (NOR) in rats: role of indirect 5-HT(1A) partial agonism. Behav Brain Res. 2013;247:158-164. doi: 10.1016/j.bbr.2013.03.027
  • Auclair AL, Kleven MS, Besnard J, Depoortère R, Newman-Tancredi A. Actions of novel antipsychotic agents on apomorphine-induced PPI disruption: influence of combined serotonin 5-HT1A receptor activation and dopamine D2 receptor blockade. Neuropsychopharmacology. 2006;31(9):1900-1909.
  • Patra P, Patra S. Research findings on overactive bladder. Curr Urol. 2015;8(1):1-21. doi:10.1159/000365682
  • Yoshimura N, Chancellor MB. Neurophysiology of lower urinary tract function and dysfunction. Rev Urol. 2003;(5):3-10.
  • Fowler CJ, Griffiths D, Groat WC. The neural control of micturition. Nature Reviews Neuroscience. 2008;9(6):453-466. doi:10.1038/nrn2401
  • Pineda RH, Nedumaran B, Hypolite J, et al. Altered expression and modulation of the two-pore-domain (K2P) mechanogated potassium channel TREK-1 in overactive human detrusor. Am J Physiol Renal Physiol. 2017;313:535–546. doi:10.1152/ajprenal.00638.2016
  • Groat WC, Wickens C. Organization of the neural switching circuitry underlying reflex micturition. Acta Physiologica. 2013;207(1):66-84. doi:10.1111/apha.12014
  • Zhang J, Cao M, Chen Y, et al. Increased expression of TREK-1 K+ channel in the dorsal root ganglion of rats with detrusor overactivity after partial bladder outlet obstruction. Med Sci Monit. 2018;24:1064-1071. doi:10.12659/MSM.908792
  • Lei Q, Pan XQ, Chang S, Malkowicz SB, Guzzo TJ, Malykhina AP. Response of the human detrusor to stretch is regulated by TREK-1, a two-pore-domain (K2P) mechano-gated potassium channel. J Physiol. 2014;592(14):3013-3030. doi:10.1113/jphysiol.2014.271718
  • Cadaveira-Mosquera A, Ribeiro SJ, Reboreda A, Lamas JA. Activation of TREK currents by the neuroprotective agent riluzole in mouse sympathetic neurons. J Neurosci.2011;31(4):1375-1385. doi:10.1523/JNEUROSCI.2791-10.2011
  • Picardo HP, Joseph H, Sanghee L, et al. Altered detrusor contractility and voiding patterns in mice lacking the mechanosensitive TREK-1 channel. BMC Urol. 2019;19:40. doi:10.1186/s12894-019-0475-3
  • Yoshimura N, Kuno S, Chancellor MB, De Groat WC, Seki S. Dopaminergic mechanisms underlying bladder hyperactivity in rats with a unilateral 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal pathway. Br J Pharmacol. 2003;139(8):1425-1432. doi:10.1038/sj.bjp.0705388
Online Türk Sağlık Bilimleri Dergisi-Cover
  • ISSN: 2459-1467
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2016
  • Yayıncı: Oğuz KARABAY
Sayıdaki Diğer Makaleler

Çocuklarda Konjenital İzole Penil Torsiyon ve Basit Cerrahi Onarımı

Mehmet ARPACIK, Hayriye Nihan KARAMAN AYYILDIZ, Semih Lütfi MİRAPOĞLU, Ceyhan ŞAHİN, Zekeriya İLCE

COVID-19 Pandemisi ve Koruyucu Tedbirlerin Çocukların Ruh Sağlığı Üzerindeki Etkisi

Ahmet Osman KILIÇ, Necati UZUN, Fatih AKIN, Abdullah YAZAR, Özge METİN AKCAN, Ömer Faruk AKÇA, İsmail RESİLİ

Nötrofil Lenfosit Oranı ve Monosit Lenfosit Oranı Çocukluk Çağı Tuberkülozu Tanısında Kullanılabilir mi?

Şefika ELMAS BOZDEMİR, Hümeyra ASLANER

Küresel Bir Olayın (COVID-19) Diş Hekimlerinin Algıladığı Tehdit ve Sosyal Destek Üzerindeki Etkisi

Gökhan KARADİREK, SÜLEYMAN KUTALMIŞ BÜYÜK, Mehmed ALPAYDIN

Agomelatin Yetişkin Sıçanlarda Skopolamin Kaynaklı Öğrenme ve Hafıza Bozukluğunu Tersine Çevirir

Sinan SARAL, Ali Koray KAYA, Atilla TOPÇU, Aykut ÖZTÜRK, Ayşegül SÜMER, Esra PINARBAŞ

Ziprasidon, Aripiprazol, Blonanserin, Siyamemazin ve Nemonaprid'in Farelerde İzole Detrusor Düz Kasına Kronik Etkileri

Mehmet Hanifi TANYERİ, Mehmet Emin BÜYÜKOKUROĞLU, Pelin TANYERİ, Rümeysa KELEŞ, Şeyma Nur BAŞARIR, Oğuz MUTLU, Firuzan AKAR, Bekir Faruk ERDEN, Güner ULAK

Hemşirelik Öğrencilerinde Uyku Kalitesi ile Akademik Başarı Arasındaki İlişkinin İncelenmesi

Gizem EKENLER, Büşra ALTINEL

Fabrika Çalışanlarında Yalnızlık, Depresyon ve Tükenmişliğin İncelenmesi

Burcu TÜFEKÇİ, Semra KARACA

COVID-19 Sürecinde Gelişen Persistan Hıçkırık: Nadir Bir Olgu

Erkut ETÇİOĞLU, Muhammet Raşit AYDIN

Parazit Enfeksiyonları: Maran, Pekan ve Kuantan'daki Aborijinler Arasında Hijyen Yardım Setinin Bulunması ile Bilgi, Tutum ve Uygulama Düzeyleri

Mohamad Helmy JAAFAR, Normalina ALIAS, Muhammad Lokman MD. ISA