İsa YUVACI, Nurettin BAYRAM, Işıl ÇAKIR, Emine PANGAL, Seda DUYGU SABUR, Özcan EREL, Almila ŞENAT

Retinopatili ve Retinopatisiz Diyabetik Hastalarda Dinamik Tiyol Disülfit Dengesi

Amaç: Retinopatisi olan ve olmayan tip 2 diyabetli hastalarda serum tiyol (T) disülfit (D) düzeylerinin ve tiyol-disülfit dengesinin (TDD) karşılaştırılması amaçlandı. Materyal ve Metot: Bu prospektif çalışma göz kliniğinde düzenli takipleri yapılan diyabetli hastalarla, onlara demografik olarak benzeyen gönüllü kontrol grubunda yapıldı. Diyabeti olan ve retinopatisi olmayan hastalar bir grubu (DMG), diyabetik retinopatisi olanlar diğer grubu (DRPG) oluştururken sağlıklı gönüllüler kontrol grubunu (KG) oluşturdu. Rutin göz muayenesini takiben 8 saatlik açlık sonrası kan örnekleri alındı. Bulgular: Tiyol seviyeleri KG’ nda; toplam T (TT) 375,18, nativ T (NT) 345,98, D 14,60, D/NT 4,30, D/TT 3,94 NT/TT 92,10 olarak bulundu (oranlar % olarak değerlendirildi). Bu değerler DMG’ unda; 402,97; 361,38; 20,79; 5,99; 5,32; 89,34 olarak bulunurken, DRPG’ nda ise; 370,29; 329,09; 20,60; 6,46; 5,70; 88,59 olarak bulundu. Gruplar arasında T seviyeleri bakımından bir fark bulunmadı. D değerleri DMG ve DRPG’ larında KG’ ndan yüksek bulunurken DMG ve DRPG arasında fark bulunmadı. D/NT, D/TT, NT/TT değerlerinde KG ile DMG ve DRPG arasında anlamlı fark bulunurken; DMG ve DRPG arasında anlamlı fark bulunmadı. Sonuç: Diyabette zamanla vücuttaki antioksidan sistemlerde oluşan yetersizlik TDD’ inde değişikliklere yol açmaktadır. Çalışmamızda D değerleri DMG ve DRPG’ larında yüksek bulundu, TDD bozulmuş izlendi.

Anahtar Kelimeler:

Disülfit, Diyabet, Retinopati, Tiyol

Dynamic Thiol Disulfide Balance in Diabetes With and Without Retinopathy

Objective: Comparison of serum thiol (T) and disulfide (D) levels and thiol-disulfide balance (TDB) in type 2 diabetic patients who have retinopathy or not. Materials and Methods: The diabetic patients were divided into two groups as patients without diabetic retinopathy (DMG) and patients with diabetic retinopathy (DRPG) and compared to the control group (CG), which included the healthy volunteers with similar demographics. Following a complete eye examination, blood samples were drawn after fasting for at least 8 hours. Results: The total T (TT), native T (NT), D, D/NT, D/TT, and NT/TT were 375.18, 345.98, 14.60, 4.30, 3.94, and 92.10 in the CG, respectively. These values were 402.97, 361.38, 20.79, 5.99, 5.32, and 89.34 in the DMG, and 370.29, 329.09, 20.60, 6.46, 5.70, and 88.59 in the DRPG, respectively. In contrast, D, D/NT, and D/TT values were significantly higher in the DMG and DRPG compared to the CG. However, no significant differences were detected between DMG and DRPG. Conclusion: This study shows that the D values were high in the DMG and DRPG, causing impaired TDB. Our results suggest that the body's antioxidant systems are inadequate over time in diabetic patients, which leads to changes in TDB in the body.

Keywords:

diabetes, disulphide, retinopathy, thoile,

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