Saadet KADER, Turan AKDAĞ, Gülhan Aksoy SARAÇ

Psoriazis Vulgaris' li Hastalarda Oksidatif Stres Belirteci ve İskemi Modifiye Albümin Düzeylerinin Değerlendirilmesi

Amaç: Sistemik inflamatuar bir deri hastalığı olan psoriazis vulgaris (PS), hücresel immün mekanizmalarıyla ilişkilidir. Çalışmamızın amacı PS' li hastalarda ve kontrollerde oksidatif stres belirteçleri ve iskemi modifiye albümin düzeylerini değerlendirmektir.Materyal ve Metot: Eylül 2020 - Mayıs 2021 tarihleri arasında dermatoloji polikliniğine başvuran ve PS tanısı konan (18 yaş üstü) katılımcılar (n=50) çalışmaya alındı. PS hastalarında nitrik oksit (NO), malondialdehit (MDA), 8-hidroksi 2-deoksi guanozin (8-OHdG), süperoksit dismutaz (SOD), glutatyon peroksidaz (GPx) parametreleri ve iskemi modifiye albümin (IMA) seviyeleri gibi oksidatif stres belirteçleri ve kontroller belirlenerek aralarındaki ilişkiler değerlendirildi.Bulgular: Çalışmaya 50 PS' li ve 50 sağlıklı kontrol olmak üzere toplam 100 gönüllü alındı. Oksidatif stres belirteçlerinin ölçümlerinde GPX, 8-OHdG, MDA, IMA, IMA/Albumin ve NO parametreleri hasta ve kontrol grupları arasında istatistiksel olarak anlamlı bulundu. Ayrıca iki psoriazis alanı ve şiddet indeksi (PASI) grubu arasında SOD, 8-OHdG, IMA ve NO istatistiksel olarak anlamlı bulundu.Sonuç: PS' li hastalarda 8-OHdG, MDA, IMA, IMA/Albumin, NO düzeylerinde yükselme ve GPx düzeylerinde azalma gözlendi. Bu konuyu netleştirmek için daha fazla ve kapsamlı çalışmalara ihtiyaç vardır.

Evaluation of Oxidative Stress Marker and Ischemia Modified Albumin Levels in Patients with Psoriasis Vulgaris

Objective: As a systemic inflammatory skin disease, psoriasis vulgaris (PS) is associated with cellular immune mechanisms. We aimed to evaluate oxidative stress markers and ischemia modified albumin levels in patients with PS and controls.Materials and Methods: The participants (over age of 18) who applied to the dermatology outpatient clinic between September 2020 - May 2021 and diagnosed with PS (n=50) were enrolled into the study. Oxidative stress markers such as nitric oxide (NO), malondialdehyde (MDA), 8-hydroxy 2-deoxy guanosine (8-OHdG), superoxide dismutase (SOD), glutathione peroxidase (GPx) parameters and ischemia modified albumin (IMA) levels in patients with PS and controls were evaluated.Results: A total of 100 volunteers, 50 with PS and 50 healthy controls were enrolled in the study. In the measurements of oxidative stress markers, GPX, 8-OHdG, MDA, IMA, IMA/Albumin and NO parameters were found to be statistically as significant between the patient and control groups. Also, SOD, 8-OHdG, IMA and NO were found to be statistically as significant between two psoriasis severity index (PASI) groups.Conclusion: Elevated levels of 8-OHdG, MDA, IMA, IMA/Albumin, NO and decreased levels of GPx were observed in patients with PS. To clarify this topic, further and comprehensive studies are needed.

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