Turan AKDAĞ, Saadet KADER, Gülhan AKSOY SARAÇ

Psoriazis Vulgaris' li Hastalarda Oksidatif Stres Belirteci ve İskemi Modifiye Albümin Düzeylerinin Değerlendirilmesi

Amaç: Sistemik inflamatuar bir deri hastalığı olan psoriazis vulgaris (PS), hücresel immün mekanizmalarıyla ilişkilidir. Çalışmamızın amacı PS' li hastalarda ve kontrollerde oksidatif stres belirteçleri ve iskemi modifiye albümin düzeylerini değerlendirmektir.

Anahtar Kelimeler:

Oksidatif stres, iskemi modifiye albumin, psoriazis vulgaris

Evaluation of Oxidative Stress Marker and Ischemia Modified Albumin Levels in Patients with Psoriasis Vulgaris

Objective: As a systemic inflammatory skin disease, psoriasis vulgaris (PS) is associated with cellular immune mechanisms. We aimed to evaluate oxidative stress markers and ischemia modified albumin levels in patients with PS and controls.

Keywords:

Oxidative stress, ischemia modified albumin, psoriasis vulgaris,

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Sikar Aktürk A, Ozdoğan HK, Bayramgürler D, Cekmen MB, Bilen N, Kıran R. Nitric oxide and malondialdehyde levels in plasma and tissue of psoriasis patients. J Eur Acad Dermatol Venereol. 2012;26(7):833-837. doi:10.1111/j.1468-3083.2011.04164.x
Karaca S, Guder H. Antioxidant system in dermatology. Turk J Dermatol. 2009;3(2):32-39.
Attwa E, Swelam E. Relationship between smoking-induced oxidative stress and the clinical severity of psoriasis. J Eur Acad Dermatol Venereol. 2011;25(7):782-787. doi:10.1111/j.1468-3083.2010.03860.x
Tekin NS, Ilter N, Sancak B, Ozden MG, Gurer MA. Nitric oxide levels in patients with psoriasis treated with methotrexate. Mediators Inflamm. 2006;2006(3):16043. doi:10.1155/MI/2006/16043
Gisondi P, Bellinato F, Girolomoni G, Albanesi C. Pathogenesis of chronic plaque psoriasis and ıts ıntersection with cardio-metabolic comorbidities. Front Pharmacol. 2020;11:117. doi:10.3389/fphar.2020.00117
Geale K, Henriksson M, Jokinen J, Schmitt-Egenolf M. Association of skin psoriasis and somatic comorbidity with the development of psychiatric illness in a Nationwide SwedishStudy. JAMADermatol. 2020;156(7):795-804.
Kimmel GW, Lebwohl M. Psoriasis: Overview and diagnosis. Evidence-Based Psoriasis. 2018:1-16. doi:10.1007/978-3-319-90107-7
Badri T, Kumar P, Oakley AM. Plaque psoriasis. [Updated 2021 Aug 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430879/. Accessed Jan 27, 2022.
Parisi R, Iskandar IYK, Kontopantelis E, et al. National, regional, and worldwide epidemiology of psoriasis: systematic analysis and modelling study. BMJ. 2020;369:m1590. doi:10.1136/bmj.m1590
Ayala-Fontánez N, Soler DC, McCormick TS. Current knowledge on psoriasis and autoimmune diseases. Psoriasis (Auckl). 2016;6:7-32. doi:10.2147/PTT.S64950
Ferreira C, Azevedo A, Nogueira M, Torres T. Management of psoriasis in pregnancy - a review of the evidence to date. Drugs Context. 2020;9:2019-11-6. doi:10.7573/dic.2019-11-6
Vičić M, Kaštelan M, Brajac I, Sotošek V, Massari LP. Current concepts of psoriasis ımmunopathogenesis. Int J Mol Sci. 2021;22(21):11574. doi:10.3390/ijms222111574
Kurutas EB. The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state. Nutr J. 2016;15(1):71. doi:10.1186/s12937-016-0186-5
Pleńkowska J, Gabig-Cimińska M, Mozolewski P. Oxidative stress as an ımportant contributor to the pathogenesis of psoriasis. Int J Mol Sci. 2020;21(17):6206. doi:10.3390/ijms21176206
Lin X, Huang T. Oxidative stress in psoriasis and potential therapeutic use of antioxidants. Free Radic Res. 2016;50(6):585-95. doi:10.3109/10715762.2016.1162301
Asha K, Singal A, Sharma SB, Arora VK, Aggarwal A. Dyslipidaemia & oxidative stress in patients of psoriasis: Emerging cardiovascular risk factors. Indian J Med Res. 2017;146(6):708-713. doi:10.4103/ijmr.IJMR-717-16
Paul S, Sen S, Nath I, Kumar A, Biswas UK. Psoriasis, an inflammatory condition associated with oxidative stress. Asian Journal of Medical Sciences, 2021;12(4):24-30. doi:10.3126/ajms.v12i4.33343
Kaur M, Sharma S, Kukreja S, Kaur J, Bassi R. Study of oxidative stress in patients of psoriasis. Int J Res Dermatol. 2016;2:95-8. doi:10.18203/issn.2455-4529
Srinivas US, Tan BWQ, Vellayappan BA, Jeyasekharan AD. ROS and the DNA damage response in cancer. Redox Biol. 2019;25:101084. doi: 10.1016/j.redox.2018.101084
Qing X, Shi D, Lv X, et al. Prognostic significance of 8-hydroxy-2′-deoxyguanosine in solid tumors: A meta-analysis. BMC Cancer. 2019;19:997. doi:10.1186/s12885-019-6189-9
Kızılyel O, Akdeniz N, Metin MS, Elmas ÖF. Investigation of oxidant and antioxidant levels in patients with psoriasis. Turk J Med Sci. 2019;49(4):1085-1088. doi:10.3906/sag-1807-257
Pektas SD, Pektas G, Oztekin A, et al. Investigation of adropin and IMA levels in psoriasis and their relation to duration and severity of disease. Our Dermatol Online. 2018;9(4):363-368.
Kaur M, Sharma S, Kukreja S, Kaur J, Bassi R. Study of oxidative stress in patients of psoriasis. Int J Res Dermatol. 2016;2(4):95-98.
Mahmouda A, Abo-Elmaged R , Fahmy H , Nada H. Estimation of nitric oxide level in psoriatic patients and its correlation with disease severity. Egypt J Dermatol Venereol. 2013;33(2):71-75.