Oral Antikoagülan Kullanan Covid-19 Hastalarının Hastane İçi Klinik Sonuçları

Amaç: Çalışmamızda varfarin ve yeni nesil oral antikoagülanların COVID-19 hastalığının prognozu üzerine etkilerini araştırmayı amaçladık. Materyal ve Metot: COVID-19 tanısı alan hastalar, varfarin veya yeni nesil oral antikoagülan kullanıp kullanmamalarına göre iki gruba ayrıldı. Her gruptaki kronik hastalık tipleri, kullanılan ilaçlar, hematolojik ve biyokimyasal parametreler ve prognozlar istatistiksel olarak analiz edildi. Bulgular: Varfarin kullanan 23 (%37,1) hasta ve yeni nesil oral antikoagülan kullanan 39 (%62,9) hasta çalışmaya dahil edildi. Her iki grup arasında demografik özellikler ve laboratuvar verileri açısından anlamlı fark yoktu. Varfarin ve yeni nesil antikoagülan gruplarında mortalite oranları benzerdi (sırasıyla %39,1 ve %43,6; p = 0,731). Ayrıca majör kanama ve entübasyon oranları sonuçlarında da iki grup arasında anlamlı fark yoktu. Sonuç: COVID-19 hastalarında varfarin ve yeni nesil oral antikoagülanların entübasyon, majör kanama ve mortalite üzerine etkileri arasında fark yoktu.

Anahtar Kelimeler:

Antikoagülasyon, Covid-19, koronavirüs, tromboz

In-Hospital Clinical Outcomes of Covid-19 Patients Treated with Oral Anticoagulants

Objective: We aimed to investigate the effects of warfarin and new-generation oral anticoagulants on the prognosis of patients diagnosed with coronavirus disease 2019 (COVID-19). Materials and Methods: Patients diagnosed with COVID-19 were divided into two groups depending on whether they were using warfarin or a new-generation oral anticoagulant. The types of chronic diseases, drugs used, hematological and biochemical parameters, and prognoses in each group were statistically analysed. Results: Twenty-three patients (37.1%) using warfarin and 39 (62.9%) patients using new-generation oral anticoagulants were included in the study. There was no significant difference between the two groups regarding demographic characteristics and laboratory data. The mortality rates for the warfarin and new-generation anticoagulant groups were similar (39.1% vs. 43.6%, respectively; p = 0.731). Also, there was no significant difference in the results of major bleeding and intubation rates between the two groups. Conclusion: There was no difference in the effects of warfarin and new-generation oral anticoagulants on mortality, intubation and major bleeding among the patients with COVID-19.

Keywords:

Anticoagulation, coronavirus, Covid-19, thrombosis,

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