Fatma ÖZDEMİR, Banu AÇMAZ, Gökhan AÇMAZ, İptisam MÜDERRİS, Selçuk MISTIK

Endometrial Hiperplazi ile Komplike Obez ve Premenopozal Hastalarda Vücut Yağ Dokusu Dağılımının Etkisi

Amaç: Obezite ile adet düzensizliği arasında yakın bir ilişki vardır.Bu çalışmanın amacı, endometriyal hiperplazili aşırı kilolu veya obez premenopozal hastalar ile benign patolojik lezyonları olan gönüllüler arasında biyoimpedans yöntemi kullanılarak lipoid doku dağılımının araştırılmasıdır.

Anahtar Kelimeler:

Endometrial hiperplazi, hiperlipidemi, kolesterol, obezite, yağ dağılımı

The Effect of Body Fat Tissue Distribution in Obese and Premenopausal Patients Complicated with Endometrial Hyperplasia

Objective: There is a close association between obesity and menstrual irregularity. This study aims to investigate lipoid tissue accumulation between overweight or obese premenopausal patients with endometrial hyperplasia and with benign pathologic lesions via using the bioimpedance method.Materials and Methods: Obese or overweight volunteers with abnormal uterine bleeding were examined. Eighty-eight volunteers meet the inclusion criteria. We obtained fat mass, fat percentage and impedance of body parts by using Multi-Frequency Body Composition Analyzer. Blood lipid profile and ultrasonographic measurement of endometrial thickness were also performed. Results: 33 volunteers were in the hyperplasia group and 55 were in the control group. 28 of the 33 volunteers (84.8%) had at least one increased fatty acid. 41 of the 55 patients (74.5%) had at least one increased fatty acid in the control group. Total cholesterol levels are higher in the hyperplasia group than in the control group (p=0.006). There was no significant difference between the groups for bioimpedance analyses. Conclusion: Hyperlipidemia remains an important factor that contributes to endometrial pathologies. Serum cholesterols were significantly high in the endometrial hyperplasia group. Rather than lipoid tissue distribution, increased cholesterol may contribute to gynecologic pathology occurrence in obese individuals complicated with endometrial hyperplasia.

Keywords:

Cholesterol, endometrial hyperplasia, fat distribution, hyperlipidemia, obesity,

PDF

___

Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 2000;894:i-xii, 1-253.
Blüher M. Metabolically healthy obesity. Endocr Rev. 2020;41(3). doi:10.1210/endrev/bnaa004
Dağ ZÖ, Dilbaz B. Impact of obesity on infertility in women. J Turk Ger Gynecol Assoc. 2015;16(2):111-117. doi:10.5152/jtgga.2015.15232
Committee on Practice Bulletins-Gynecology. Practice bulletin no. 128: diagnosis of abnormal uterine bleeding in reproductive-aged women. Obstet Gynecol. 2012;120(1):197-206. doi:10.1097/AOG.0b013e318262e320
Mircea CN, Lujan ME, Pierson RA. Metabolic fuel and clinical implications for female reproduction. J Obstet Gynaecol Can. 2007;29(11):887-902. doi:10.1016/S1701-2163(16)32661-5
Tong Q, Xu Y. Central Leptin Regulation of Obesity and Fertility. Curr Obes Rep. 2012;1(4):236-244. doi:10.1007/s13679-012-0025-8
Ellegård L, Aldenbratt A, Svensson MK, Lindberg C. Body composition in patients with primary neuromuscular disease assessed by dual energy X-ray absorptiometry (DXA) and three different bioimpedance devices. Clin Nutr ESPEN. 2019;29:142-148. doi:10.1016/j.clnesp.2018.11.004
Emons G, Beckmann MW, Schmidt D, Mallmann P; Uterus commission of the gynecological oncology working Group (AGO). New WHO classification of endometrial hyperplasias. Geburtshilfe Frauenheilkd. 2015;75(2):135-136. doi:10.1055/s-0034-1396256
Xu WH, Matthews CE, Xiang YB, et al. Effect of adiposity and fat distribution on endometrial cancer risk in Shanghai women. Am J Epidemiol. 2005;161(10):939-947. doi:10.1093/aje/kwi127
Raffone A, Travaglino A, Saccone G, et al. Diabetes mellitus and responsiveness of endometrial hyperplasia and early endometrial cancer to conservative treatment. Gynecol Endocrinol. 2019;35(11):932-937. doi:10.1080/09513590.2019.1624716
Więch P, Ćwirlej-Sozańska A, Wiśniowska-Szurlej A, et al. The relationship between body composition and muscle tone in children with cerebral palsy: A case-control study. Nutrients. 2020;12(3):864. doi:10.3390/nu12030864
Manna PR, Molehin D, Ahmed AU. Dysregulation of aromatase in breast, endometrial, and ovarian cancers: An overview of therapeutic strategies. Prog Mol Biol Transl Sci. 2016;144:487-537. doi:10.1016/bs.pmbts.2016.10.002
Zaidi M, Lizneva D, Kim SM, et al. FSH, bone mass, body fat, and biological aging. Endocrinology. 2018;159(10):3503-3514. doi:10.1210/en.2018-00601
Giannella L, Cerami LB, Setti T, Bergamini E, Boselli F. Prediction of endometrial hyperplasia and cancer among premenopausal women with abnormal uterine bleeding [published correction appears in Biomed Res Int. 2020:3653414 doi:10.1155/2019/8598152
Kaya S, Kaya B, Keskin HL, Kayhan Tetik B, Yavuz FA. Is there any relationship between benign endometrial pathologies and metabolic status? J Obstet Gynaecol. 2019;39(2):176-183. doi:10.1080/01443615.2018.1469606