Seher YİLMAZ, Adem TOKPINAR, Şükrü ATEŞ, Ünal ÖZTEKİN, Serife ALPA, Yeşim GÖÇMEN

Effect of Cornus Mas L. Extract on Organs in Rats Given Nicotine

Nicotine plays an important role in oxidative stress formation. For this purpose, to reveal the antioxidant effect of cornelian cherry plant, the effects of nicotine-induced oxidative stress. 28 adult Wistar Albino (180-220 g) male rats were used in the study. Rats were divided into four groups as control group (n = 6), cornelian cherry group (n = 7), nicotine group (n = 7) and nicotine + cornelian cherry group (n = 8). While nicotine extract was applied to the experimental group, cornelian cherry extract was applied to the treatment group as well as nicotine. TBARS, SOD, GSH, GSSG, TOS, TAS, Redox potential values were measured by spectrophotometric analysis in lung, brain, kidney, heart and liver tissues. OSI and GSH / GSSG values were calculated as TOS / TAS and GSH / GSSG rates, respectively. When the experimental groups are examined, it is seen that there is a significant difference between the nicotine-treated group and the other groups (p

Keywords:

Oxidative stress, Cornus mas L, Nicotine, Cornelian cherry,

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