MEAN PLATELET VOLUME (MPV) FOR PREDICTING PROGNOSIS OF RECTUM CANCER AFTER NEOADJUVANT TREATMENT

Aim:Rectum cancer is a subtype of colorectal cancer. Its etiology and etiopathogenesis is similar to colon cancer. However, it is differentiated from colon tumors because of its anatomic location and treatment approach. In the literature, Mean Platelet Volume (MPV) has been shown to correlate with inflammation in gastrointestinal cancer patients. Based on this fact, we aimed to evaluate the MPV value for predicting prognosis of rectum cancer patients who are treated with neoadjuvant chemoradiotherapy. Materials and Methods:We retrospectively collected the data of 80 operated rectum adenocarcinoma patients who were treated neoadjuvant chemoradiotherapy between 2011 and 2018. MPV value was investigated as prognostic factors for disease free survival. Results:Fifty-five patients were male (69%). Median age was 56 (range 22 to 83 years). The most common histopathologic was adenocarcinoma (94%). The ideal cut-off value of pretreatment MPV that predicted disease-free survival was 7.65 in the ROC analysis [AUC:0.74 (0.63-0.85); p

Rektum Kanserinin Prognozunu Öngermede Ortalama Trombosit Hacmi (MPV)'nin Rolü

Amaç:Rektum kanseri kolorektal kanserlerin alt tipidir. Etyopatogenezi kolon kanserlerine benzemekle birlikte, tedavi yaklaşımında farklılıklar vardır. Literatürde ortalama trombosit volümü (MPV) ile gastrointestinal kanser hastalarındaki inflamasyonla ilişki gösterilmiştir. Bu nedenle çalışmamızda neoadjuvan tedavi alan rezeke rektum kanseri hastalarının prognozunu belirlemede MPV değerinin rolünü değerlendirmeyi amaçladık. Materyal ve Metot:2011-2018 yılları arasında neoadjuvan kemoradyoterapi almış opere 80 rektum adenokarsinom tanılı hastanın verileri retrospektif olarak değerlendirildi. MPV ‘nin hastalıksız sağ kalım için prognostik önemi araştırıldı. Bulgular:Hastaların 55'i (%69) erkekti. Medyan yaş 56 (minimum 22-maksimum 83) idi. En sık görülen histopatolojik tip adenokarsinomdu(94%). MPV için ideal kestirim değeri 7,65 saptandı [AUC:0.74 (0.63-0.85) / p

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