Mehmet YANIK, Gamze ERFAN, Feti TÜLÜBAŞ, Mustafa ORAN, Mustafa KULAÇ

Makrofaj Migrasyon İnhibitör Faktör Değerlerinin Tekrarlayan Aftöz Stomatit Hastalığıyla İlişkisi

Özet Giriş Tekrarlayan aftöz stomatit(TAS) en sık görülen mukozal hastalıktır ve etyolojisi bilinmemektedir. Makrofaj inhibisyon faktör(MIF) T hücre aktivasyonunda önemli rolü olan proinflamatuar bir sitokindir. Çalışmamızda MIF’in TAS etyolojisindeki önemi incelenmiştir. Materyal-Metod Çalışmaya polikliniğimize başvuran 18 yaşından büyük 70 TAS hastası ve 44 adet gönüllü olmak üzere toplam 114 kişi dahil edilmiştir. Hasta ve kontrol grubu serum MIF değerleri ELISA ile değerlendirilmiştir. Bulgular TAS grubunda ortalama MIF değeri ile kontrol grubunda ortalama MIF değerleri açısından anlamlı fark bulunamamıştır. TAS skoru 5 ve altında olanlar ile 6 ve üzeri olanlar MIF değeri açısından karşılaştırılmıştır ve istatistiksel olarak anlamlı fark bulunamamıştır. Rekürrens sıklığı ve MIF değerleri arasında anlamlı fark bulunamamıştır. Sonuç MIF’in TAS hastalığında da etyolojik faktörler arasında olabileceğini düşünerek yaptığımız çalışmada istatistiksel olarak anlamlı bir sonuç elde edemedik. Abstract Introduction Recurrent aphtous stomatitis (RAS) is the most common mucosal disease with unknown etiology. Macrophage inhibition factor(MIF) is a proinflamatory cytokine which has a role in T cell activation. This study aimed to investigate importance of MIF in etiology of RAS. Material and Methods 70 patients who were above the age of 18, clinically diagnosed RAS and 72 healthy volunteers were included into the study. Patients and control subjects were examined for MIF seroprevalence by ELISA. Results There were no significant difference between RAS and control groups in mean values of MIF. In comparison of RAS patients in two subgroups- with RAS score above 6 and with 5 and less than 5, there were also no significant difference between these subgroups in mean values of MIF. On the other hand; the reccurrence of lesions and mean values of MIF showed no relevance. Conclusion Eventhough proposed in the hypothesis of this study, there had been no statistically significant relationship between MIF and RAS etiology.

Anahtar Kelimeler:

Tekrarlayan aftöz stomatit, Makrofaj migrasyon inhibitör faktör, T hücre

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Aim Recurrent aphtous stomatitis (RAS) is the most common mucosal disease with unknown etiology. Macrophage migration inhibitory factor (MIF) is a proinflamatory cytokine which has a role in T cell activation. This study aimed to investigate importance of MIF in etiology of RAS. Materials and Methods 70 patients who were above the age of 18, clinically diagnosed RAS and 72 healthy volunteers were included into the study. Patients and control subjects were examined for MIF seroprevalence by ELISA. Results There were no significant difference between RAS and control groups in mean values of MIF. In comparison of RAS patients in two subgroups- with RAS score above 6 and with 5 and less than 5, there were also no significant difference between these subgroups in mean values of MIF. On the other hand the reccurrence of lesions and mean values of MIF showed no relevance. Conclusion Eventhough proposed in the hypothesis of this study, there had been no statistically significant relationship between MIF and RAS etiology

Keywords:

Recurrent aphtous stomatitis, Macrophage migration inhibitory factor, T cell,

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