Suat CAKİNA, Şamil OZTÜRK, Selma YÜCEL, Cemre Cagan POLAT

Aurasız Migrenli Hastalarda Oksidatif Stres Parametreleri

Amaç: Migren moleküler mekanizmaları henüz net bir şekilde tanımlanmamış çok yönlü bir nörolojik hastalıktır. Oksidatif stresin, migrenin patogenezinde de rol oynadığına inanılmaktadır. Bu çalışmanın amacı, aurasız migren hastalarında serum paraoksonaz (PON) ve arilesteraz (ARE) aktiviteleri , tiyol düzeyleri, iskemi-modifiye albumin (İMA), total oksidan kapasite (TOK), total antioksidan kapasite (TAK) ve oksidatif stres indeksini (OSİ) araştırmaktır.Materyal ve Metot: Aurasız migrenli 30 hasta (5 erkek ve 25 kadın) ve 30 sağlıklı kontrol (8 erkek ve 22 kadın) çalışmaya dahil edildi. Çalışma gruplarında spektrofotometrik yöntemle serum PON,ARE, tiyol düzeyleri, İMA, TAK, TAK ve OSİ indeksi belirlendi. İstatistiksel analiz Mann-Whitney U testi ve bağımsız örneklem t-testi kullanılarak yapıldı ve p

OXIDATIVE STRESS PARAMETERS IN PATIENTS WITH MIGRAINE WITHOUT

Aim: Migraine is a multifaceted neurological disease whose molecular mechanisms are not yet clearly defined. Oxidative stress is also believed to play a role in the pathogenesis of migraine. The purpose of this study was to evaluate serum paraoxonase (PON) and arylesterase (ARE) activities, thiols levels, ischemia-modified albumin (IMA), the total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) in patients with migraine without aura. Materials and Methods: 30 patients (5 males and 25 females) and 30 matched healthy controls (8 males and 22 females) were enrolled. Serum PON and ARE activities, thiols levels, IMA, TAS, TOS and OSI were determined by using the spectrophotometric method in the study groups. Statistical analysis was conducted using Mann–Whitney U test and independent samples t-test, and p

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