Meryem KORKMAZ, Berna KUŞ, Emre DİRİCAN, Abdullah ARPACI

Orak Hücre Anemili Hastalarda Osteoporoz ile İlişkili Biyokimyasal Markerlerin Tanıdaki Yeri

Amaç: Orak hücreli anemi (OHA)’de osteopeni ve osteoporoz riski net olarak ortaya konmamıştır. Bu çalışmada OHA-osteoporoz ilişkisini araştırmak amacıyla kemik yapım/yıkım belirteçleri bir arada değerlendirilerek aralarındaki korelasyonun incelenmesi amaçlandı. Gereç ve Yöntem: Çalışmanın hasta grubu 33 orak hücreli birey ve kontrol grubu ise 34 sağlıklı bireyden oluşturuldu. Kemik yapım belirteçlerinden Tip 1 kollajen N-terminal propeptit (P1NP), Tip 1 kollajen C-terminal propeptit (P1CP), Kemik Alkalen Fosfataz (BALP) ve Osteokalsin (OC), kemik yıkım belirteçlerinden ise, Tip 1 kollajen karboksiterminal bağlı telopeptit (CTX), Pridinolin (PYD) ve Deoksipridinolin (DPD) ve Hidroksiprolin (HYP) analiz edildi. Ayrıca grupların 25(OH)D düzeyleri ölçüldü. Bulgular: OC düzeyi hasta grubunda kontrol grubuna kıyasla anlamlı derecede yüksekti. (p=0.016). 25(OH)D düzeyi hasta grubunda kontrol grubuna kıyasla önemli ölçüde düşüktü. (p=0.01). Gruplar arasında diğer yapım ve yıkım belirteçlerinde (PINP, PICP, PYD, DPD, BALP, CTX, HYP) istatistiksel olarak anlamlı fark bulunmadı. Sonuç: OHA’nın kemik metabolizmasına etkisinin anlaşılmasında kemik döngüsü belirteçlerinin de değerlendirilmesinin tanıya daha fazla katkıda bulunacağı öngörülmüştür.

Anahtar Kelimeler:

Orak Hücre, Osteopeni, Osteoporoz, Kemik Döngüsü Belirteçleri

The Role of Biochemical Markers Associated with Osteoporosis in Patients with Sickle Cell Anemia in Diagnosis

Objective: The risk of osteopenia and osteoporosis has not been clearly defined in sickle cell anemia (SCA). In this study, it was aimed to evaluate the bone formation/resorption markers together and examine the relationships between each other in order to investigate the relationship between SCA and osteoporosis. Methods: Our study included 33 patients with sickle cell anemia and 34 healthy controls. Bone formation markers are Type 1 collagen N-terminal propeptide (P1NP), Type 1 collagen C-terminal propeptide (P1CP), Bone Alkaline Phosphatase (BALP) and Osteocalcin (OC), and bone resorption markers are Type 1 collagen carboxyterminal telopeptide (CTX), Pyridinoline (PYD) and Deoxypyridinoline (DPD) and Hydroxyproline (HYP) were analyzed. In addition, 25(OH)D levels of the groups were assayed. Results: The OC level was significantly higher in the patient group compared to the control group (p=0.016). 25(OH)D level was significantly decreased in the patient group compared to the control group (p=0.01). There was no statistically significant difference between the groups for both bone formation and resorption markers (PINP, PICP, PYD, DPD, BALP, CTX, HYP). Conclusion:It is predicted that the evaluation of bone turnover markers will contribute more to the diagnosis in understanding the effect of SCA on bone metabolism.

Keywords:

Sickle Cell Anemia, Osteopenia, Osteoporosis, Bone Tunover Markers,

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