Kronik İshalin Nadir Bir Sebebi: Eozinofilik Kolit

Amaç: Eosinofilik kolit (EK) kronik ishalin nadir ancak hayat kalitesi üzerine uzun süreli olumsuz etkileri nedeniyle önemli bir sebebidir. Ülkemizden EK ile ilgili yayınlar sınırlı olup, bu yazıda kliniğimiz bu konudaki verilerinin paylaşılması amaçlanmıştır. Gereç ve Yöntem: Çalışmaya Mayıs 2016 ve Haziran 2020 tarihleri arasında kronik ishal etyolojisi araştırılmak üzere kolonoskopi yapılan ve patolojik inceleme sonucu EK tanısı konan vakalar dahil edildi. Hastaların demografik özellikleri, klinik özellikleri, labaratuvar değerleri, kolonoskopik ve patolojik verileri retrospektif olarak incelendi. Bulgular: Çalışmaya 22 erkek ve 14 kadın olmak üzere toplam 36 vaka dahil edildi. Erkeklerin yaş ortalaması 42.6 (23-67) ve kadınların yaş ortalaması 52.2 yıl (18-75) idi. Başlıca klinik başvuru sebepleri ishal, karın ağrısı ve rektal kanama idi. Tanı öncesi şikayet süresi ortalama 13,7 ay (2-48) ve tanı sonrası ortalama takip süresi 16.5 ay (2-49) idi. Periferik euzonofili 7/36 vakada saptandı. Tüm hastalara metilprednisolon 16-32 mg/gün dozunda verildi. Tartışma ve sonuç: EK kronik ishalin hayat kalitesini etkileyen önemli bir sebebidir. Metilprednisolon tedavisi son derece etkili ve güvenlidir. Klinik şüphe ve kolonoskopik biyopsilerin histopatolojik incelenmesi tanı için en önemli faktörlerdir.

Anahtar Kelimeler:

Kronik ishal, Kolit, Eosinofilik infiltrasyon

A Rare Cause of Chronic Diarrhea: Eosinophilic Colitis

Aim: Eosinophilic colitis (EC), which is rare but has adverse effects on the quality of life, is an important reason for chronic diarrhea. However there is limited publishing related to EC in our country and here we aim to share our clinic’s data on this issue. Material and Method: The subjects, who had colonoscopy and were diagnosed with EC with reference to pathological examination, were included to the study to analyse the chronic diarrhea aetiology between May 2016 and June 2020. Demographic qualifications, clinical features, laboratory results, colonoscopy and pathological data of the patients have been studied in as retrospectively. Results: Totally 36 subjects including 22 men and 14 women, were involved into the study. The age average of men was 42.6 (23 to 67 ages) and the age average of women was 52.2 (18 to 75 ages). The main clinical application reasons were diarrhea, stomach ache and rectal bleeding. The complaint period before diagnosis is 13.7 months (2 to 48) and the follow-up period after diagnosis is 16.5 months (2 to 49). The peripheral eosinophilia was detected with 7 out 36 cases. Methylprednisolone was administrated by patients as 16 to 32 mg/day as a dosage. Discussion and Conclusion: The EC is an important cause of chronic diarrhea that affects the quality of life. Methylprednisolone treatment is extremely efficient and safe. The clinical suspicion and examination of colonoscopy biopsy are important factors for diagnosis.

Keywords:

Chronic diarrhea, Colitis, Eosinophilic infiltration,

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