DİYET VE DİYABET

Bir metabolik sendrom bileşeni olan Tip 2 Diyabetes Mellitus, insülin direncine bağlı gelişen ilerleyici insülin sekresyon defekti ile karakterizedir. Tip 2 diyabetli hastaların çoğu obezdir ve obezite insulin direncinin bir ölçüde sebebidir. Obezite diyet ile de yakından ilişkilidir. Diyet kaynaklı obezitede özellikle hazır gıdalar suçlanmaktadır. Yüksek yağlı ve yüksek fruktozlu diyet obeziteye ve insülin direncine zemin hazırlayabilir. Sunulan derlemenin amacı diyabetes mellitus patogenezinde diyet alışkanlıklarının öneminin vurgulanmasıdır.

Anahtar Kelimeler:

Diyabet, diyet, insülin direnci

Diet and Diabetes

Being a metabolic syndrome component, Type 2 Diabetes Mellitus is characterized with progressive insuline secretion defect induced by insuline resistance. Type 2 diabetes patients are mostly obese and obesity is, to a certain extent, the reason of insuline resistance. Obesity is also closely associated with diet. In diet originated obesity, the blame is particularly put on ready-made food. High fat and high fructose diet can lead to obesity and insuline resistance. The purpose of the presented compilation is to emphasize the importance of the habits of diet in the patogenesis of diabetes mellitus

Keywords:

Diabetes, diet, insuline resistance,

PDF

___

1. Sefil F, Ulutas KT, Dokuyucu R, Sumbul AT, Yengil E, Yagiz AE, et al. Investigation of neutrophil lymphocyte ratio and blood glucose regulation in patients with type 2 diabetes mellitus. The Journal of international medical research. 2014;42(2):581-8. Epub 2014/02/26.
2. Gokce C, Aycan-Kaya O, Yula E, Ustun I, Yengil E, Sefil F, et al. The effect of blood glucose regulation on the presence of opportunistic Demodex folliculorum mites in patients with type 2 diabetes mellitus. The Journal of international medical research. 2013;41(5):1752-8. Epub 2013/08/13.
3. American Diabetes A. Diagnosis and classification of diabetes mellitus. Diabetes care. 2013;36 Suppl 1:S67-74. Epub 2013/01/04. , 4. Satman I, Yilmaz T, Sengul A, Salman S, Salman F, Uygur S, et al. Population-based study of diabetes and risk characteristics in Turkey: results of the turkish diabetes epidemiology study (TURDEP). Diabetes care. 2002;25(9):1551-6. Epub 2002/08/28.
5. Satman I, Omer B, Tutuncu Y, Kalaca S, Gedik S, Dinccag N, et al. Twelve-year trends in the prevalence and risk factors of diabetes and prediabetes in Turkish adults. European journal of epidemiology. 2013;28(2):169-80. Epub 2013/02/15.
6. Tanoue S, Uto H, Kumamoto R, Arima S, Hashimoto S, Nasu Y, et al. Liver regeneration after partial hepatectomy in rat is more impaired in a steatotic liver induced by dietary fructose compared to dietary fat. Biochemical and biophysical research communications. 2011;407(1):163-8. Epub 2011/03/05.
7. Huang BW, Chiang MT, Yao HT, Chiang W. The effect of high-fat and high-fructose diets on glucose tolerance and plasma lipid and leptin levels in rats. Diabetes, obesity & metabolism. 2004;6(2):120-6. Epub 2004/01/30.
8. Bray GA, Nielsen SJ, Popkin BM. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. The American journal of clinical nutrition. 2004;79(4):537-43. Epub 2004/03/31.
9. Roncal-Jimenez CA, Lanaspa MA, Rivard CJ, Nakagawa T, Sanchez-Lozada LG, Jalal D, et al. Sucrose induces fatty liver and pancreatic inflammation in male breeder rats independent of excess energy intake. Metabolism: clinical and experimental. 2011;60(9):1259-70. Epub 2011/04/15.
10. Miller WC, Lindeman AK, Wallace J, Niederpruem M. Diet composition, energy intake, and exercise in relation to body fat in men and women. The American journal of clinical nutrition. 1990;52(3):426-30. Epub 1990/09/01.
11. Hackett AF, Court S, McCowen C, Parkin JM. Dietary survey of diabetics. Archives of disease in childhood. 1986;61(1):67-71. Epub 1986/01/01.
12. Tappy L. Q&A: 'toxic' effects of sugar: should we be afraid of fructose? BMC biology. 2012;10:42. Epub 2012/05/23.
13. Radziuk J, Pye S. Hepatic glucose uptake, gluconeogenesis and the regulation of glycogen synthesis. Diabetes/metabolism research and reviews. 2001;17(4):250-72. Epub 2001/09/07.
14. Cherrington AD. Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo. Diabetes. 1999;48(5):1198-214. Epub 1999/05/20.
15. Triplitt CL. Examining the mechanisms of glucose regulation. The American journal of managed care. 2012;18(1 Suppl):S4-10. Epub 2012/05/18.
16. Jiang GQ, Zhang BB. Glucagon and regulation of glucose metabolism. Am J Physiol-Endoc M. 2003;284(4):E671-E8.
17. Johnson RJ, Perez-Pozo SE, Sautin YY, Manitius J, Sanchez-Lozada LG, Feig DI, et al. Hypothesis: Could Excessive Fructose Intake and Uric Acid Cause Type 2 Diabetes? Endocrine reviews. 2009;30(1):96-116.
18. Tappy L, Le KA. Does fructose consumption contribute to non-alcoholic fatty liver disease? Clinics and research in hepatology and gastroenterology. 2012;36(6):554-60.
19. Yang ZH, Miyahara H, Takeo J, Katayama M. Diet high in fat and sucrose induces rapid onset of obesity-related metabolic syndrome partly through rapid response of genes involved in lipogenesis, insulin signalling and inflammation in mice. Diabetology & metabolic syndrome. 2012;4(1):32. Epub 2012/07/06.
20. Schulze MB, Manson JE, Ludwig DS, Colditz GA, Stampfer MJ, Willett WC, et al. Sugarsweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women. JAMA : the journal of the American Medical Association. 2004;292(8):927-34. Epub 2004/08/26.
21. Lim JS, Mietus-Snyder M, Valente A, Schwarz JM, Lustig RH. The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome. Nature reviews Gastroenterology & hepatology. 2010;7(5):251-64. Epub 2010/04/07.
22. Kawasaki T, Kashiwabara A, Sakai T, Igarashi K, Ogata N, Watanabe H, et al. Long-term sucrose-drinking causes increased body weight and glucose intolerance in normal male rats. The British journal of nutrition. 2005;93(5):613-8. Epub 2005/06/25.
23. Stanhope KL, Havel PJ. Fructose consumption: considerations for future research on its effects on adipose distribution, lipid metabolism, and insulin sensitivity in humans. The Journal of nutrition. 2009;139(6):1236S-41S. Epub 2009/05/01.
24. Stanhope KL, Havel PJ. Fructose consumption: recent results and their potential implications. Annals of the New York Academy of Sciences. 2010;1190:15-24. Epub 2010/04/15.
25. Nomura K, Yamanouchi T. The role of fructose-enriched diets in mechanisms of nonalcoholic fatty liver disease. The Journal of nutritional biochemistry. 2012;23(3):203-8. Epub 2011/12/02.
26. Alegret M, Laguna JC. Opposite fates of fructose in the development of metabolic syndrome. World journal of gastroenterology : WJG. 2012;18(33):4478-80. Epub 2012/09/13.
27. Item F, Konrad D. Visceral fat and metabolic inflammation: the portal theory revisited. Obesity reviews : an official journal of the International Association for the Study of Obesity. 2012;13 Suppl 2:30-9. Epub 2012/11/01.
28. Lam YY, Mitchell AJ, Holmes AJ, Denyer GS, Gummesson A, Caterson ID, et al. Role of the gut in visceral fat inflammation and metabolic disorders. Obesity. 2011;19(11):2113-20. Epub 2011/09/02.
29. Manco M, Mingrone G, Greco AV, Capristo E, Gniuli D, De Gaetano A, et al. Insulin resistance directly correlates with increased saturated fatty acids in skeletal muscle triglycerides. Metabolism: clinical and experimental. 2000;49(2):220-4. Epub 2000/02/26.
30. Kien CL, Bunn JY, Ugrasbul F. Increasing dietary palmitic acid decreases fat oxidation and daily energy expenditure. The American journal of clinical nutrition. 2005;82(2):320-6. Epub 2005/08/10.
31. Hunnicutt JW, Hardy RW, Williford J, McDonald JM. Saturated fatty acid-induced insulin resistance in rat adipocytes. Diabetes. 1994;43(4):540-5. Epub 1994/04/01.
32. Park SW, Zhou Y, Lee J, Ozcan U. Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity. Proceedings of the National Academy of Sciences of the United States of America. 2010;107(45):19320-5. Epub 2010/10/27.

Mustafa Kemal Üniversitesi Tıp Dergisi-Cover

ISSN: 2149-3103
Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 2010
Yayıncı: Hatay Mustafa Kemal Üniversitesi Tıp Fakültesi Dekanlığı

Arşiv