Karbonhidrat Antijen 125 ve Kalp Yetersizliğinin Klinik Şiddeti Arasındaki İlişki

Kalp yetmezliği (KY) olan hastalarda karbonhidrat antijeni (CA) 125 ve brain natriüretik peptidi (BNP) seviyeleri artar. Bu çalışmada KY'li hastalarda CA 125 ve BNP düzeylerini araştırmayı ve bu biyomarkerlar ile fonksiyonel kapasite arasındaki olası ilişkiyi değerlendirmeyi amaçladık. Çalışmaya toplam 48 hasta dahil edildi (28 erkek, 20 kadın). Ortalama yaş 67.6. KY tanısı, anamnez, fizik muayene, elektrokardiyografi, telekardiyografi ve transtorasik ekokardiyografi ile konuldu. Tüm hastaların klinik durumları NYHA sınıflandırması kullanılarak belirlendi. KY'li hastalar NYHA sınıflamasına göre iki gruba ayrıldı: B grubu hafif-orta KY' li (I ve II) hastalar (toplam 20 hasta, 12 erkek ve 8 kadın, ortalama 65 yaş) ve A grubu ağır KY' li ( III ve IV) (toplam 28 hasta, 16 erkek ve 12 kadın, ortalama 70,2). Ortalama yaş Grup A ve Grup B'de 70.2 ve 65 idi (p=0.078). Ortalama EF, Grup A'da %28±10 iken, Ortalama EF, Grup B'de %32±11 idi (p=0.0012). Grup A'daki serum CA 125 ve Pro BNP düzeyleri (CA 125=176.38 U/ml ve Pro BNP=36465.06 pg/ml), B grubunda (CA 125=50.7 U/ml ve Pro BNP=122.65 pg/ml) anlamlı derecede yüksek bulundu. (p<0.001). CA 125 ve pro BNP, kalp yetmezliği hastalarının degerlendirmesinde umut verici bir biyobelirteçtir. CA 125 serum seviyesi ile HF evresi arasınsa istatistiksel anlamlı ilişki vardır.

Anahtar Kelimeler:

CA 125, Pro BNP, Kalp Yetmezliği, Sol Ventrikül, Marker

The Association Between Carbohydrate Antigen 125 and Clinical Severity of Heart Failure

Carbohydrate antigen (CA) 125 and brain natriuretic peptide (BNP) levels increase in patients with heart failure (HF). In this study, we aimed to investigate CA 125 and pro-BNP levels in patients with HF and evaluate possible relationship between these biomarkers and functional capacity. A total of 48 patients were involved in the study (28 men, 20 women). They were aged 67.6 years on average. HF was diagnosed based on medical history, physical examination, electrocardiography, telecardiography and transthoracic echocardiography. The clinical statuses of all patients were assigned by being used NYHA classification. Patients with HF were categorized into two groups according to NYHA classification: Group B was with mild-moderate HF (I and II) (a total of 20 patients, 12 men and 8 women, aged 65 on average) and Group A was with severe HF (III and IV) (a total of 28 patients, 16 men and 12 women, aged 70.2 on average). The mean age was 70.2 years and 65 years in Group A and Group B, (p = 0.078). The mean EF was 28±10% in Group A, while the mean EF was 32±11% in Group B (p=0.0012). Serum CA 125 and Pro BNP levels in group A (CA 125=176.38 U/ml, and Pro BNP=36465.06 pg/ml) were found significantly higher than those in group B (CA 125=50.7 U/ml and Pro BNP=122.65 pg/ml) (p<0.001). CA 125 and pro BNP are a promising biomarker in the assessment of heart failure patients. There was a statistically significant relationship between CA 125 serum level and HF stage.

Keywords:

CA 125, Pro BNP, Heart failure, Left ventricle, Markers,

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