Gokhan OZGUR, İlker TASCI, Serkan TAPAN, Gurkan CELEBI, Ali SELCUK, Battal ALTUN, Gurhan TASKIN, Alper SONMEZ, Bilgin Bahadir BASGOZ, Gokhan ERDEM

İzole Hiperkolesterolemili Olgularda Terapötik Yaşam Şekli Değişikliği ve HMG-KoA Redüktaz İnhibitörü Tedavisinin Kan TWEAK (TNF-related weak inducer of apoptosis) Düzeyi Üzerine Etkisi

İzole hiperkolesterolemi genel popülasyonda sık görülen bir durumdur. Tedavide terapötik yaşam tarzı değişikliği ve/veya statin tedavisi altın standarttır. TWEAK, TNF süper familya-sından bir sitokindir ve akut dönemde doku rejenerasyonunda rol oynar, ayrıca kronik dö-nemde doku hasarında da rol oynar. Bu çalışmada, ilk 12 haftalık yaşam tarzı değişikliği ve 12 haftalık statin tedavisine yanıt olarak izole LDL kolesterol yüksekliği olan hastaların plazma TWEAK düzeylerini araştırdık. Sonuç olarak, terapötik yaşam tarzı değişikliğinden sonra hedef LDL seviyelerine ulaşabilen dislipidemi hastalarında plazma sTWEAK düzeyi artmıştır. Bununla birlikte, dislipideminin statin ile düzeltilmesi, plazma sTWEAK seviyesinde herhangi bir değişiklik gözlenmemiştir.

Anahtar Kelimeler:

Hidroksimetilglutaril KoA Redüktaz İnhibitörleri, Hiperkolesterolemi, Sitokin TWEAK, Yaşam Tarzı Değişikliği

The Effects of Lifestyle Modification and HMG-Coa Reductase Inhibitor Treatment on Blood Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK) Levels Among Patients with Isolated Hypercholesterolemia

Isolated hypercholesterolemia is a frequent condition in the general population. It is managed mostly by therapeutic lifestyle intervention and/or statin treatment. TWEAK is a cytokine from the TNF superfamily and plays a role in tissue regeneration in acute period; it is also involved in tissue damage in chronic period. In this study, we investigated plasma TWEAK levels of participants with isolated LDL cholesterol elevation in response to first 12 weeks of lifestyle modification, and 12 weeks of statin treatment. In conclusion, plasma sTWEAK level increased in dyslipidemia patients who were able to reach target LDL levels after therapeutic lifestyle modification. However, correcting dyslipidemia with statin was not associated with any change in plasma sTWEAK level.

Keywords:

Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypercholesterolemia, Cytokine TWEAK, Lifestyle Modification,

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