Dilek UZLU, Leyla BAYKAL SELÇUK, Adem TURK, Şeyda Ece OĞUZER, Ahmet Duhan OZBAY, Yasin YASAR

Sistemik izotretionin tedavisinin retina sinir lifi tabakası kalınlığı ve kornea endotel hücre yoğunluğu üzerindeki etkileri

Amaç Sistemik izotretinoin tedavisinin retina sinir lifi tabakası (RSLT) kalınlığı ve kornea endotel hücre yoğunluğu üzerindeki etkilerini değerlendirmek Yöntem Otuz üç hasta çalışmayı tamamladı. Tüm hastalara başlangıçta ve tedavi süresince tedavinin başlangıcından altı ay sonra oftalmik muayene yapıldı. Tüm hastalara düzeltilmiş görme keskinliği, göz içi basıncı, kırma kusurları, biyomikroskopik ön segment ve fundus muayenesini içeren detaylı bir göz muayenesi yapıldı. Ayrıca tüm hastalara topikal anestezi yapılmadan Schirmer testi, gözyaşı kırılma zamanı bakıldı, optik koherens tomografi ile retina sinir lifi kalınlık ölçümleri ve speküler mikroskopi ölçümleri yapıldı. Bulgular 23 kadın (%69.7) ve 10 erkek (%30.3) hasta dahil edildi. Tedavi sonrası RSLT kalınlığı hem sağ hem de sol gözde tedavi öncesi değerlerden anlamlı derecede düşüktü (P=0.048 ve P

Anahtar Kelimeler:

izotretinoin, göz, kornea, retina

Effects of systemic isotretinoin treatment on retinal nerve fiber layer thickness and corneal endothelial cell density

Objective To investigate the effects of systemic isotretinoin therapy on retinal nerve fiber layer (RNFL) thickness and corneal endothelial cell density (ECD) Methods Thirty-three patients completed the study. All patients were given an ophthalmic examination at baseline and after six months of isotretinoin therapy. All patients underwent a detailed eye examination including best corrected visual acuity, intraocular pressure, refractive errors, biomicroscopic anterior segment and fundus examination. In addition, Schirmer test without topical anesthesia, tear break up time, retinal nerve fiber thickness measurements with optical coherence tomography (OCT) and specular microscopy measurements were performed on all patients. Results There were 23 female (69.7 %) and 10 male (30.3 %) patients. Post treatment RNFL values were significantly lower than pretreatment values on both right and left eyes (P=0.048 and P

Keywords:

isotretinoin, eye, cornea, retina,

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ISSN: 2651-2750
Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 2018
Yayıncı: Doğu Karadeniz Deri ve Zührevi Hastalıklar Derneği

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