Radiotherapy (RT) is one of the most important treatment options of cancer and also may activates immun response. Because of this we must discuss the question of “is the radiotherapy vaccine”. If RT increases the immun response we must learn some more about the RT effects on the cells, cell surface antigene, immun checkpoints and their inhibition (ICI; CTLA4, PD1, PDL1 inhibition). It will be discussed the role of the radiotherapy and biologic effects of the radiotherapy to activate the immun response, radiotherapy dose, radiotherapy timing and the side effects of immun checkpoints inhibitors. But with high conformal hypofractionated stereotactic radiotherapy the microenvironment around the cancer tissue such as fibroblast may survives and then may helps cancer stem cell progression.