Evaluation of the Efficiency of Neuronavigation in Patients with Glioblastoma

Objective: To investigate the effect of neuronavigation use on mortality in patients with glioblastoma. Methods: For each of the 26 patients that underwent neuronavigation-assisted supratotal resection for glioblastoma between 2018 and 2020, one patient that underwent supratotal resection without navigation was selected. Results: Radiographic radicality was observed in 35% of the cases in the neuronavigation-assisted surgery group and 29% of those in the conventional surgery group. Absolute and relative residual tumor volumes were significantly lower in the neuronavigation-assisted surgery group. Radical tumor resection was associated with a very significant increase in survival. There was no significant difference in the survival rates between the patients that underwent surgery with and without neuronavigation. This was attributed to the small number of participants and supratotal resection being performed in all statistically determined patients The low median survival period of glioblastoma may have also contributed to this finding. Conclusions: Surgery plays an important role in the treatment of glioblastoma. A combination of techniques including intraoperative magnetic resonance imaging, neuronavigation, ultrasound, and fluorescence guidance allows for safe and maximum surgical resection, leading to better outcomes in terms of survival and postoperative functional recovery. However, despite maximal surgical resection and adjuvant chemotherapy-radiotherapy, most cases develop tumor recurrence within 10 months, which is considered to be due to established cancer stem cells. Therefore, there is an urgent need to develop more effective treatment strategies for glioblastoma.

Keywords:

Neuronavigation, Glibastoma, Supratotal resection Mortality,

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