Birgül MAZMANCI, Ali AŞKIN, Lülüfer TAMER

Sıçanlarda Lambda Siyalotrinin Akut Toksik Etkisinin Araştırılması

Türkçe Özet:Amaç: Bu çalışmada etken maddesi lambda siyalotrin olan pyrethroid insektisitlerden Karate Zeon\'un (LC) dişi ve erkek sıçanlarda enzimatik ve enzimatik olmayan biyokimyasal parametreler üzerine akut toksik etkisinin araştırılması amaçlanmıştır. Yöntem: LC nin 0.8mg/kg, 3.06mg/kg ve 6.12mg/kg dozları dişi ve erkek sıçanlara bir kez intraperitoneal olarak enjekte edilmiştir. Uygulamadan 24 saat sonra antikoagülan içeren tüplere kalp kanları alınmıştır. Alınan kan santrifüj edilerek elde edilen plazmada karaciğer hasarının göstergesi olarak alanin aminotransferaz (ALT), aspartat aminotransferaz (AST), laktat dehidrogenaz (LDH) enzim aktiviteleri ve albumin (ALB), bilirubin (BİL) düzeyleri, böbrek hasarının göstergesi olarak ÜRE ve kreatinin (KREA) düzeyleri ölçülmüştür. Bulgular: LC dişi ve erkek sıçanlarda ALT, AST, LDH enzim aktivitelerini, ALB, BİL, ÜRE ve KREA düzeylerini kontrol grubuna göre farklı düzeylerde arttırmış en önemli artışlar 3.06mg/kg ve 6.12mg/kg doz gruplarında olmuştur. Sonuç: Elde edilen bulgular LC\'nin memelilerde karaciğer ve böbrekte doku hasarı oluşturma potansiyeline sahip olduğunu göstermiştir. LC\'nin toksik etkisi doza bağlı olarak artmaktadır.

Anahtar Kelimeler:

lambda siyalotrin, toksik etki, doku hasarı

Sıçanlarda Lambda Siyalotrinin Akut Toksik Etkisinin Araştırılması

AbstractInvestigation of Acute Toxic Effects of Lamda-Cyhalothrin in Rats Objective: In this study, we investigated the acute toxic effects of pyrethroid insecticide Karate Zeon, whose active gradient is lambda-cyhalothrin (LC), on enzymatic and non-enzymatic parameters of male and female rats. Method: LC was administrated intraperitoneally to male and female rats once in three different doses as 0.8 mg/kg, 3.06mg/kg and 6.12mg/kg. After the last treatment with pesticide, blood samples drawn by cardiac puncture were collected in vials containing anticoagulant. After blood samples were centrifuged, alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) enzyme activities, albumin (ALB), and bilirubin (BIL) levels were measured as indicators of hepatic injury; and URE and creatinine (CREA) levels as indicators of kidney injury were measured in plasma. Result: ALT, AST, LDH enzyme activities, and ALB, BIL, UREA and CREA levels were increased by LC in female and male rats compared with the control group. Significantly increases were observed in 3.06mg/kg and 6.12mg/kg dose groups. Conclusion: These results indicate the potential of LC in inducing liver and kidney tissue damage in mammalians. Toxic effects of LC increase in relation to dose.

Keywords:

lambda cyhalothrin, toxic effect, tissue damage,

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Mersin Üniversitesi Sağlık Bilimleri Dergisi-Cover

Yayın Aralığı: Yılda 3 Sayı
Başlangıç: 2008
Yayıncı: Mersin Üniversitesi Sağlık Bilimleri Enstitüsü

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