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• 1. Monacada, S., Palmer, R.M.J. and Higgs, E.A., Nitric oxide: physiology, pathophysiology, and pharmacology, Pharmacol. Rev. 43, 109-142, 1991.
• 2. Lowenstein, C.J., Snyder, S.H., Nitric oxide, a novel biologic messenger, Cell 70, 705, 1992.
• 3. Xie, Q.W., and Nathan, C, The high-output nitric oxide pathway: role and regulation, J. Leukocyte Biol. 56, 576, 1992.
• 4. Manolova, N., Maximova, V., Manolova, Z., Stoilova, I., Korczak, E., and Denis, A., Immunobiological effect of propolis. I. Effect on cellular immunity, Acta Microbiol. Bulg. 21, 76-81, 1987.
• 5. Neychev, H., Dimov, V., Vuleva, V., Shirova, L., Slavcheva, E., Gegova, G., Manolova, N., Bankova, V., Immunomodulatory action of propolis, II. Effect of water-soluble fraction on inf­luenza infection in mice, Acta Microbiol. Bulg., 23, 58-62, 1988.
• 6. Scheller, S., Gazda, G., Pietsz, G., Gabrys, J., Szumlas, J., Eckert, L., Shani, J., The ability of ethanol extract of propolis to sti­mulate plaque formation in immunized mouse spleen cells. Pharmacol. Res., Commun, 20, 323-328, 1988.
• 7. Basic, I., Orsolic, N., Tadic, Z., Macedo Fereire Alcici, N., Brbot Saranovic, A., Bendelja, K., Krsnik, B., Rabatic, S., Antime-tastatic effect of propolis, caffeic acid phenethyl ester and caf-feic acid on mammary carcinoma of CBA mouse, 17th Inter­national Cancer Congress, Rio de Jeneiro, Brazil, 1, 63-75, 1998.
• 8. Dimov, V., Ivanovska, N., Manolova, N., Bankova, V., Nikolov, N., Popov, S., Immunodulatory action of propolis, Influence on anti-infectious protection and macrophage function, Api-dologie, 22, 155-162, 1991.
• 9. Dimov, V., Ivanovska, N., Bankova, V., Popov, S., Immunodulatory action of propoolis, IV. Prophylactic activity against gram-negative infections and adjuvant effect of the water-so­luble derivate, Vaccine, 10, 817-823, 1992.
• lO. Meltzer, M.S., Oppenheim, J.J., Bidirectional amplification of macrofage-lymphocyte activation factor production by activa­ted adherent mouse peritoneal cells, J. Immunol, 118, 77-82, 1977.
• ll. Meltzer, M.S., Tucker, R.W., Sanford, K.K., Leonard, E.J., Inte­raction of Bcg-activated macrophages with neoplastic and non- neoplastic cell line in vitro: quantitation of the cytotoxic reaction by release of tritiated thymidine from prelabeled tar­get cells, J. Natl. Cancer Inst., 45, 1177 -1184, 1975.
• 12. Natan, C.F., and Hibbs, J.B. Jr., Role of nitric oxide synthesis in macrophage antimicrobial activity, Curr. Opin. Immunol, 3, 65-69, 1991.
• 13. De La Harpe, J. Nathan, C.F., A semi-automated microassay for H2O2 release by human blood monocytes and mouse peritone­al macrophages, J. Immunol, Methods 78, 323-326, 1988.
• 14. Urban, J.L., Shepard, H.M., Rothstein, J.L., Sugarman, B.J., Schreiber, H., Tumor necrosis factor: a potent effector mole­cule for tumor cell killing by activated macrophages, Proc. Natl. Acad. Sci., USA, 83, 5233, 1986.
• 15. Stuehr, D.J., Nathan, C.F., Nitric oxide: a macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells, J. Exp. Med., 169, 1543-1555, 1989.
• 16. Nikolov, N., Marekov, N., Bankova, V., Popov, S., Ignatova, R., Vladimirova, I., Method for the preparation of water-soluble S.derivative of propolis, Bulgarian Journal of Patology Appli­ed 79903/28, 05, 1987.
• 17. Grunberger, D., Banerjee, R., Eisinger, K., Oltz Efros, E.H.L., Caldwell, M., Estevez V., Nakanishi, K., Preferential cytoto-xicity on tumor cells of caffeic acid phenethyl ester isolated from propolis, Experientia 44, 230-232, 1988.
• 18. Nathan, C.F., Secretory products of macrophages, J. Clin. Invest., 79, 319-326, 1987.
• 19. Hibbs, J.B., Taintor, R.R., Vavrin, Z., Rachlin, E.M., Nitric oxide: a cytotoxic activated macrophage effactor molecule, Biochem, Biophys, Res. Commum, 157, 87, 1988.
• 20. Hibbs, J.B., Taintor, R.R. Jr., Vavrin, Z., Macrophage cytotoxicity: role for L-arginine deiminase and imino-nitrogen oxida­tion to nitrite, Science 253, 473-476, 1987.
• 21. MacMicking, J., Xie, Q-W., Nathan, C, Nitric oxide and macrop­hage function, Annu. Rev. Immunol, 15, 323-350, 1997.
• 22. Keller, R., Keist, R., Wechsler, A, Leist, T.P., Van Der Meide, P.H., Mechanismus of macrophage-mediated tumor-cell kil­ling: a comparative a nalysis of the roles of reactive nitrogen intermediates and tumor necrosis factor, Int. J. Cancer, 46, 682-686, 1990.
• 23. Ivanovska, M., Stefanova, Z., Valeva, V., Neychev, H., Immunodulatory action of propolis: VII. A comparative study on cin-namic and caffeic acid lysine derivatives, Comptes Rendus de I1 Academie Bulgare des Sciences, 46, 115-117, 1993.
• 24. 0rsi, R.O., Funari, S.R.C., Soares, A.M.V.C., Calvi, S.A., Oliveira, S.L., Sforcin, J.M., Bankova, V., Immunomodulatory ac­tion of propolison macrophage activation, Journal of Venom Animals Toxins, 6,1-11, 2000.
• 25. Chan, W.S., Wen, P.C., Chiang, H.C., Structure-activity relationship of caffeic acid analogues on xantine oxidase, Antican-cer Res., 15,703-707, 1995.
• 26. Monks, T.J., Lau, S.S., Biological Reactivity of Polyphenolic-Glutathione Conjugates, Chem. Res. Toxicol, 10, 1296-1313, 1997.
• 27. Kono, K., Salazaronfray, F., Petersson, M., Hansson, J., Masucci, G., Wasserman, K., Nakazawa, T., Anderson, P., Kiessling, R., Hydrogen peroxide secreted by tumor-derived macropha­ges down-modulates signal-transducing zeta molecules and inhibits tumor-specific T cell- and natural killer cell-mediated cytotoxicity, Eur. J. Immunol, 26, 1308-1313, 1996.
• 28,Orsolic, N., Horvat-Knezevic, A., Basic, 1., Propolis as a new potential immunomodulator in mice: antimetastatic activity of a water-soluble derivate of propolis (WSDP), MeUifera 2: 29-46, 2002.
• 29,Orsolic, N. and Basic, I., Immunomodulation by water-soluble derivative of propolis (WSDP) a factor of antitumor reactivity, J. Ethnopharmacology, 84: 265-273, 2003.
• 30. Allison, A.C., Mechanismus by which activated macrophages inhibit Lymphocyte responses, Immunol, Rev., 40, 1-5, 1978.
• 31. Namgoong, S.Y., Baek, H.J., Lee, C.H., Kim, H.P., Effects of isoflavonoids on mouse lymphocyte proliferation in vitro, Arch. Pharmacal Res., 17, 236-239, 1994.
• 32.Kung, J.T., Brooks, S.B., Jakway, J.P., Leonard, L.L., Talmage, D.W., Suppression of in vitro cytotoxic response by macrophages due to induced arginase, J.Exp. Med., 146, 665-669, 1977.
• 33.Metzger, Z., Hoffeld, J.T., Oppenheim, J.J., Macrophage mediated suppression of murine Lymphocyte proliferantion, J. Immunol, 124, 983-987, 1980.
• 34. Kimoto, T., Arai, S., Kohguchi, M., Aga, M., Nomura, Y., Micallef, M.J., Kurimoto, M., Mito, K., Apoptosis and suppression of tumor growth by artepillin C extracted from Brazilian propolis, Cancer Detect. Prev., 22, 506-15, 1998.
• 35.Murad, J.M., Calvi, S.A., Soares, A.M.V.C., Bankova, V., Sforcin, J.M., Effect of propolis from Brazil and Bulgaria on fungicidal activity of macrophages against Paracoccidioides bra-siliensis, J. Ethnopharmacology, 79, 331-304, 2002.
• 36. Kurland J.I., Klincade, P.V, Moore, M.A.S., Regulation of B-lymphocyte clonal proliferation by stimulatory and inhibitory macrophage-derived factors, J. Exp. Med., 146, 1420-1435, 1977.
• 37,Orsolic, N„ Basic, I., Immunostimulatory and antitumor activity of a water-soluble derivative of propolis (WSDP), Period. Biol., 103, 255-261,2001.