İsmail KAYAĞİL, Derya KILIÇ, Şeref DEMİRAYAK

Bazı 2- (4-(1-Sübstitüebenzimidazol-2-il) tiyazol-2-ilamino)-4-Ariltiyazol Türevlerinin Sentezlenmesi, Yapılarının Aydınlatılması ve Lepidium sativum L. Tohumları Üzerinde Herbisit Etkilerinin Araştırılması

Tarımsal alanlarda sorunlara yol açan allelopatik bitkilerle mücadele için kullanılan herbisitler iyi tarım ürünleri elde edebilmesi için oldukça önemlidir. Herbisit etki yorumu yapılabilmesi için, fitotoksik etkileri incelenmek üzere bir dizi özgün bileşik sentezlenmiştir. Bunun için öncelikle 2-asetilbenzimidazol pek çok basamakta elde edilmiştir. Sonrasında ikinci konumundan bir 2-aminotiyazol halkası kapatılmıştır. Bu bileşiğin amino grubu tiyoüreye çevrilmiştir. Tüm bu adımlardan sonra hedeflenen bileşiklere ulaşmak için gerekli başlangıç maddeleri elde edilmiştir. Sonrasında hazırlanan arilasetil bromür bileşikleri yardımıyla yeni bir tiyazol halkası oluşturularak hedeflenen bileşikler sentezlenmiştir. Hedef bileşikler olan 2-(4-(1-Sübstitüebenzimidazol-2-il)tiyazol-2-ilamino)-4-ariltiyazol türevleri tamamen özgün olup, yapıları, elementel analiz, IR, NMR ve MS spektral verileri yardımıyla aydınlatılmıştır. Sentezlenen bileşiklerin, biyolojik aktiviteleri Lepidium sativum L. (tere) tohumları ile test edilmiştir. Bu biyolojik aktiviteler sonucunda bileşiklerin fitotoksik etkileri bulunmuştur.

Anahtar Kelimeler:

Aminotiyazol, Benzimidazol, Herbisit etki, Fitotoksik etki

Synthesis and Characterization of some Novel 2-(4-(1-substitutedbenzimidazole-2-yl) thiazole-2-ylamino)-4-Arylthiazole Derivatives and Investigation of their Herbicidal Effects on the Seeds of Lepidium sativum L.

Herbicides used to fight with allopathic plants causing harmful effect in agricultural lands are very important to obtain good agricultural products. To interpret of herbicidal effect a series of original compounds synthesized to investigate phytotoxic effects. For this, firstly, 2-acetylbenzimidazole has been obtained with many steps. After, it has been condensed 2-aminothiazole ring from second position of benzimidazole. After that, the amino group has been transformed to thiourea. After all of these steps, the all needed starting materials have been synthesized to attain the desired target compounds. Finally, the prepared arylacetyl bromide compounds and the starting compounds have been reacted with each other and formed new thiazole rings thus, target compounds have been synthesized. The synthesized 2-(4-(1-Substitutedbenzimidazole-2-yl)thiazole-2-ylamino)-4-arylthiazole derivatives as target compounds are novel compounds and their structures has been elucidated by using elemental analysis; IR, NMR and MS spectral data. The synthesized compounds have been tested on seeds of Lepidium sativum L. (cress) to study of their biological activities. Consequently, it was found that these compounds have phytotoxic effects based on their biological activities.

Keywords:

Aminothiazole, Benzimidazole, Herbicidal effect, Phytotoxic effect,

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