The Relationship Between Hepatic Activity Index and Serum Tumor Necrosis Factor Alpha Levels in Patients with Chronic Active Hepatitis-B and Chronic Active Hepatitis-C

In the present study, we investigated the relationship between serum TNF-α levels and hepatic activity in liver biopsies of chronic hepatitis B and C patients.The study was performed on 30 chronic hepatitis B patients, 25 chronic hepatitis C patients and 25 healthy controls. Serum samples of patients who underwent biopsy and healthy controls were collected. Control group was seronegative for hepatitis and had normal liver function tests. TNF- α levels measured by ELISA. Knodell’s hepatic activity index was used in evaluation of liver biopsies. Serum TNFα levels were determined higher in chronic hepatitis B and C patients than control group. HAI and TNF- α compared in chronic hepatitis B and C patients. Although we detected a relationship between HAI and TNF-α levels in chronic hepatitis B patients, no true correlation was shown in chronic hepatitis C patients. Cytokines have an important role in progression of chronic hepatitis B and C infections. There is a relationship between hepatic activity index and TNF-α level in chronic hepatitis B infection.But There is not relationship between hepatic activity index and chronic hepatitis C infection.only in two patients and both of them where in the middle of their reproductive age while as symptomatic ovarian cysts was a more common finding in unmarried females in 21-28 years of age group. This study concluded that laparoscopy has a diagnostic as well as a therapeutic implication in management of NSAP

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1. Leblebicioglu H, Eroglu C. Acute hepatitis B virus infection in Turkey: Epidemiology and genotype distribution. Clin Microbiol Infect. 2004;10(6):537-41.

2. Ezechi OC, Kalejaiye OO, Gab-Okafor CV, Oladele DA, Oke BO, Musa ZA, Ekama SO, Ohwodo H, Agahowa E, Gbajabiamilla T, Ezeobi PM, Okwuraiwe A, Audu R RA, Okoye RN, David AN, Odunukwe NN, Onwujekwe DI, Ujah IA.Sero-prevalence and factors associated with Hepatitis B and C co-infection in pregnant Nigerian women living with HIV Infection. Pan Afr Med. J. 2014(13);17:197.

3. Halota W, Flisiak R, Boroń-Kaczmarska A, Juszczyk J, Pawłowska M, Simon K, Tomasiewicz K, Małkowski P. Standards of hepatitis C treatment. Recommendations of Polish Group of Experts--2014. Przegl Epidemiol. 2014;68(3):469-74.

4. Goyal A, Murray JM. The impact of vaccination and antiviral therapy on hepatitis B and hepatitis d epidemiology. PLoS One. 2014;9(10):9-10.

5. Lin CS, Chang CS, Yang SS, Yeh HZ, Lin CW. Retrospective evaluation of serum markers APRI and AST/ALT for assessing liver fibrosis and cirrhosis in chronic hepatitis B and C patients with hepatocellular carcinoma. Intern Med. 2008;47(7):569- 75.

6. Liu YR, Lin BB, Zeng DW, Zhu YY, Chen J, Zheng Q, Dong J, Jiang JJ. Alphafetoprotein level as a biomarker of liver fibrosis status: a cross-sectional study of 619 consecutive patients with chronic hepatitis B. BMC Gastroenterol. 2014;16:14:145.

7. Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N, Wollman J. Formulation and application of a numerical scoring system for assesing histological activity in asemptomatic chronic active hepatitis. Hepatology. 1981;1:431-5.

8. Zylberberg H, Rimaniol AC, Pol S, Mason A. Solubl tumor necrosis factor receptors in chronic hepatitis C: J Hepatol. 1999;30(2):185-91.

9. Milich DR, Jones JE, Hughes JL, Price J, Raney AK, McLachlan A. Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero? Proc Natl Acad Sci. USA. 1990;87(17):6599-603.

10. Lau JY, Davis GL, Kniffen J, Qian KP, Urdea MS, Chan CS, Mizokami M, Neuwald PD, Wilber JC. Significance of serum hepatitis C virus RNA levels in chronic hepatitis C. Lancet. 1993;41(8859):1501-4.

11. Fang JW, Shen WW, Meager A, Lau JY. Activation of the tumor necrosis factor-alpha system in the liver in chronic hepatitis B virus infection. Am J Gastroenterol. 1996;91(4):748-53.

12. Tartaglia LA, Rothe M, Hu YF, Goeddel DV. Tumor necrosis factor’s cytotoxic activity is signaled by the p55 TNF receptor. Cell.1993;73(2):213-16.

13. Higuchi M, Aggarwal BB. Differential roles of two types of TNF receptor in TNFinduced cytotoxicity, DNA fragmentation, and differentiation. J Immunol. 1994;152(8):4017-25.

14. Tai DI, Tsai SL, Chen TC, Lo SK, Chang YH, Liaw YF. Modulation of tumor necrosis factor receptors 1 and 2 in chronic hepatitis B and C: the differences and implications in pathogenesis. J Biomed Sci. 2001;8(4):321-27.

15. Tsui LV, Guidotti LG, Ishikawa T, Chisari FV. Posttranscriptional clearance of hepatitis B virus RNA by cytotoxic T lymphocyte- activated hepatotytes. Proc Natl Acad Sci USA. 1995;92(26):12398-402.

16. Zaigham Abbas, Tariq Moatter, Akber Hussainy, Wasim Jafri. Effect of cytokine gene polymorphism on histological activity index, viral load and response to treatment in patients with chronic hepatitis C genotype 3. World J Gastroenterol. 2005;11(42):665- 66.

17. Zou B, Ling Q, Huo J, Lin L, He J, Pan Y. The clinic significance of serum hyaluronate and tumor necrosis factor alpha levels in liver disease Hunan Yi Ke Da Xue Xue Bao. 1998;23(1):97-9.

18. Kakumo S, Okumura A, İshikawa T, Yano M, Enomoto A, Nishimura H, Yoshioka K, Yoshika Y. Serum levels of IL-10, IL-15 and soluble tumour necrosis factor-alpha (TNF-alpha) receptors in type C chronic liver disease. Clin Exp Immunol. 1997;109(3):458-63.

19. Bradham CA, Plümpe J, Manns MP, Brenner DA, Tautwein C. Mechanisms of hepatic toxicity I. TNF-induced liver injury. Am J Physiol. 1998;275(3 Pt 1):387-92.

20. Akpolat N, Yahsi S, Godekmerdan A, Demirbag K, Yalniz M. Relationship between serum cytokine levels and histopathological changes of liver in patients with hepatitis B. World J Gastroenterol. 2005;11(21):3260-3.

21. Yamada Y, Kirillova I, Peschon JJ, Fausto N. Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking typeI tumor necrosis factor receptor. Proc Natl Acad Sci USA. 1997;94(4):1441-6.

22. Tilg H, Diehl AM. Cytokines in alcoholic and nonalcoholic steatohepatitis. New England Journal of Medicine. 2000;343(20):1467-76.
Medicine Science-Cover
  • ISSN: 2147-0634
  • Yayın Aralığı: 4
  • Başlangıç: 2012
  • Yayıncı: Effect Publishing Agency ( EPA )
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