One of the most common causes of hearing loss depends on noise overexposure. Noise is a stress factor that has auditory, psychological and physiological effects. Noise causes overproduction of stress hormones, sleep disturbances and impairment of cellular immunity. The effect of noise that inflicts organic damage on the human hearing system varies depending on intensity, and duration of the noise and individual susceptibility. There are several anatomical and physiologic abnormalities caused by noise overexposure. These abnormalities vary from the minimal loss of metabolic activities of hair cells and stiffness of stereocilia to total loss of organ of corti and the auditory nerve. The opportunity to treat and prevent noise induced hearing loss may increase with the clarification of the mechanism of cochlear damage in noise. Understanding of these mechanisms is important for development of new agents for treatment or prevention of noise induced hearing loss. In this report, we reviewed the pathological changes of the cochlea in noise induced hearing loss in the light of the literature.
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1. Prasher D. Is there evidence that enviromental noise is immunotoxic. Noise Health. 2009;11(44):151-5.
2. Bayazıt YA. Yükses ses enerjisine bağlı işitme kayıpları. Otoloji ve Nöro-otoloji 2013;2(45):723-32.
3. Belgin E, Çalışkan M. Çalışma yaşamında gürültü ve işitmenin korunması. TTB yayınları. Nisan 2004.
4. Patuzzi R. Non-linear aspects of outer hair cell transduction and the temporary threshold shifts after acoustic trauma. Audiol Neurootol. 2002;7(1):17-20.
5. Tsuprun V, Schachern PA, Cureoglu S, and Paparella M. Structure of the side links and morphology of auditory hair bundle in relation to noise exposure in the chinchilla. J Neurocytol. 2003;32(9):1117-28.
6. Nordmann AS, Bohne BA, and Harding GW. Histopathological differences between temporary and permanent threshold shift. Hear Res. 2000;139(1-2):13-30.
7. Wang Y, Hirose K, Liberman MC. Dynamics of noise-induced cellular injury and repair in the mouse cochlea. J Assoc Res Otolaryngol. 2002;3(3):248-68.
8. Puel JL, Ruel J, Gervais d'Aldin C, and Pujol R. Excitotoxicity and repair of cochlear synapses after noisetrauma induced hearing loss. Neuroreport. 1998;9(9):2109-14.
9. Pujol R, Puel JL, D'Aldin CG and Eybalin M. Pathophysiology of the glutamatergic synapses in the cochlea. Acta Otolaryngol. 1993;113(3):330-4.
10. Lamm K and Arnold W. The effect of blood flow promoting drugs on cochlear blood flow, perilymphatic pO(2) and auditory function in the normal and noise-damaged hypoxic and ischemic guinea pig inner ear. Hear Res. 2000;141(1-2):199-219.
11. Henderson D, Bielefeld EC, Harris KC, Hu BH. The role of oxidative stress in noiseinduced hearing loss. Ear Hear. 2006;27(1):1-19.
12. Nuttall AL. Sound-ınduced cochlear ıschemia/hypoxia as a mechanism of hearing loss. Noise Health. 1999;2(5):17-32.
13. Chen GD. Effect of hypoxia on noise-induced auditory impairment. Hear Res. 2002;172(1-2):186-95.
14. Clerici WJ and Yang L. Direct effects of intraperilymphatic reactive oxygen species generation on cochlear function. Hear Res. 1996;101(1-2):14-22.
15. Bielefeld EC, Hu BH, Harris KC, Henderson D. Damage and threshold shift resulting from cochlear exposure to paraquat-generated superoxide. Hear Res. 2005;207(1- 2):35-42.
16. Yamane H, Nakai Y, Takayama M, Konishi K, Iguchi H, Nakagawa T, Shibata S, Kato A, Sunami K, Kawakatsu C. The emergence of free radicals after acoustic trauma and strial blood flow. Acta Otolaryngol Suppl. 1995;519:87-92.
17. Miller JM, Brown JN and Schacht J. 8-Iso-prostaglandin F(2alpha), a product of noise exposure, reduces inner ear blood flow. Audiol Neurootol. 2003;8(4):207-21.
18. Hu BH, Henderson D, Nicotera TM. Involvement of apoptosis in progression of cochlear lesion following exposure to intense noise. Hear Res. 2002;166(1-2):62-71.
19. Han WJ, Shi XR, Nuttall A. Noise-induced nitrotyrosine increase and outer hair cell death in guinea pig cochlea. Chin Med J (Engl). 2013;126(15):2923-7.
20. Xia A, Song Y, Wang R, Simon S, Clifton W, Raphael P, Chao SI, Pereira FA, Groves AK, Oghalai JS. Prestin regulation and function in residual outer hair cells after noise- ınduced hearing loss. Plos one. 2013; 8(12):1-13.
21. Huang M, Kantardzhieva A, Scheffer D, Liberman MC, Chen ZY. Hair cell overexpression of ıslet1 reduces age-related and noise-ınduced hearing loss. J Neurosci. 2013;33(38):15086-94.
22. Wang SL, Yu LG, Liu RP, Zhu WZ, Gao WM, Xue LP, Jiang X, Zhang YH, Yi D, Chen D, Zhang YH. Gene-gene interaction of GJB2, SOD2, and CAT on occupational noise-induced hearing loss in Chinese Han Population. Biomed Environ Sci. 2014;27(12):965-8.
23. Zhang X, Liu Y, Zhang L, Yang Z, Shao Y, Jiang C, Wang Q, Fang X, Xu Y, Wang H, Zhang S, Zhu Y. Genetic variations in protocadherin 15 and their interactions with noise exposure associated with noise-induced hearing loss in Chinese population. Environ Res. 2014;135:247-52.
24. Fujioka M, Kanzaki S, Okano HJ, Masuda M, Ogawa K, Okano H. Proinflammatory cytokines expression in noise-induced damaged cochlea. J Neurosci Res. 2006;83(4):575-83.
25. Braga MP, Maciel SM, Marchiori LL, Poli-Frederico RC. Association between interleukin-6 polymorphism in the -174 G/C region and hearing loss in the elderly with a history of occupational noise exposure. Braz J Otorhinolaryngol. 2014;80(5):373-8.
26. Kou ZZ, Qu J, Zhang DL, Li H and Li Y. Noise-induced hearing loss is correlated with alterations in the expression of GABAB receptors and PKC gamma in the murine cochlear nucleus complex. Front Neuroanat. 2013;7:25.
27. Zuccotti A, Kuhn S, Johnson SL, Franz C, Singer W, Hecker D, Geisler HS, Köpschall I, Rohbock K, Gutsche K, Dlugaiczyk J, Schick B, Marcotti W, Rüttiger L, Schimmang T, Knipper M. Lack of brain-derived neurotrophic factor hampers ınner hair cell synapse physiology, but protects against noise-ınduced hearing loss. J Neurosci. 2012;32(25):8545-53