BELMA HALİLOĞLU, GÜLEN TÜYSÜZ KİNTRUP, Avni KAYA

The effect of vitamin B12 deficiency on the GH-IGF1 axis

Vitamin B12 (B12) deficiency is associated with growth retardation, reduced serum osteocalcin levels, lower bone mineral density, and increased bone fracture risk, yet the underlying mechanisms remain unclear. However, a recent study showed that B12 positively regulates postweaning growth and bone formation via taurine. B12 deficiency causes growth hormone resistance (GH) and IGF1 (Insulin-like growth factor-1) deficiency. In the present study, we aimed to evaluate the effect of B12 deficiency on the axis of GH-IGF1 and serum taurine level. Eighteen children with B12 deficiency (B12 düzeyi

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1. Kalhan SC, Marczewski SE. Methionine, homocysteine, one carbon metabolism and fetal growth. Rev Endocr Metab Disord. 2012;13(2):109–19.

2. Stabler SP. Vitamin B12 deficiency. N Engl J Med. 2013;368(21):2041-2.

3. Tucker KL, Hannan MT, Qiao N, Jacques PF, Selhub J, Cupples LA, Kiel DP. Low plasma vitamin B12 is associ- ated with lower BMD: the Framingham Osteopo- rosis Study. J Bone Miner Res. 2005;20(1):152-8.

4. Muthayya S, Kurpad AV, Duggan CP, Bosch RJ, Dwarkanath P, Mhaskar A, Mhaskar R, Thomas A, Vaz M, Bhat S, Fawzi WW. Low maternal vitamin B12 sta- tus is associated with intrauterine growth retarda- tion in urban South Indians. Eur J Clin Nutr. 2006;60(6):791-801.

5. Xian L, Wu X, Pang L, Lou M, Rosen CJ, Qiu T, Crane J, Frassica F, Zhang L, Rodriguez JP, Xiaofeng Jia, Shoshana Yakar, Shouhong Xuan, Argiris Efstratiadis, Mei Wan, Xu Cao. Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells. Nat Med. 2012;18(7):1095–101.

6. Verner A, Craig S, McGuire W. Effect of taurine supplementation on growth and development in preterm or low birth weight infants. Cochrane Data-base Syst Rev. 2007;4:CD006072.

7. Roman-Garcia P, Quiros-Gonzalez I, Mottram L, Lieben L, Sharan K, Wangwiwatsin A, Tubio J, Lewis K, Wilkinson D, Santhanam B, Sarper N, Clare S, Vassiliou GS, Velagapudi VR, Dougan G, Yadav VK. Vitamin B₁₂-dependent taurine synthesis regulates growth and bone mass. J Clin Invest. 2014 Jul;124(7):2988-3002