Sepsis is an important cause of neonatal death and perinatal brain damage, particularly in preterm infants. It is thought that activation of the inflammatory cascade triggered by cytokine may play a role in the pathogenesis of sepsis. Recent evidence supports a role for resistin in inflammation. There are no data in the literature on resistin levels in neonates with sepsis, which can also cause an inflammatory response. The objective of this study was to evaluate the role of resistin as an indicator in neonatal sepsis. Forty neonates considered to have sepsis were included in the study. Forty gestational and postnatal age- and sex-matched neonates without prolonged premature rupture of membrane or sepsis had served as controls. The mean resistin level of the neonates with sepsis was 115 ng/mL and was higher than those of the control group (41.1 ng/ mL ). There was statistically significant direct correlations between serum resistin and both TLC and CRP. The sensitivity, specificity, positive, and negative predictive values for resistin were 100%, 93%, 96%, and 100%, respectively. Resistin levels were higher in newborns with sepsis and correlated with TLC and CRP levels, which are indicators of neonatal sepsis. This suggests that resistin may also be used in the diagnosis of neonatal sepsis.
___
Meadow W, Frain L, Ren Y, et al. Serial assessment of mortality in the neonatal intensive care unit by algorithm and intuition: certainty, uncertainty, and informed consent. Pediatrics. 2002;109(5):878-86.
Edgar JD, Gabriel V, Gallimore JR, et al. A prospective study of the sensitivity, specificity and diagnostic performance of soluble intercellular adhesion molecule 1, highly sensitive C-reactive protein, soluble E-selectin and serum amyloid A in the diagnosis of neonatal infection. BMC Pediatr. 2010;10:22.
Kocabaş E, Sarikçioğlu A, Aksaray N, et al. Role of procalcitonin, C-reactive protein, interleukin-6, interleukin-8 and tumor necrosis factor-alpha in the diagnosis of neonatal sepsis. Turk J Pediatr. 2007;49(1):7-20.
Steppan CM, Bailey ST, Bhat S, et al. The hormone resistin links obesity to diabetes. Nature. 2001;409(6818):307-12.
Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol, 2006;6(10):772-83.
Mazaki-Tovi S, Vaisbuch E, Romero R, et al. Hyper resistinemia—a novel feature in systemic infection during human pregnancy. Am J Reprod Immunol. 2010;63(5):358-69.
JJohansson L, Linnér A, Sundén-Cullberg J, et al. Neutrophil-derived hyper resistinemia in severe acute streptococcal infections. J Immunol. 2009;183(6):4047-54.
Sundén-Cullberg J, Nyström T, Lee ML, et al. Pronounced elevation of resistin correlates with severity of disease in severe sepsis and septic shock. Crit Care Med. 2007;35(6):1536-42.
Bone RC. The pathogenesis of sepsis. Ann Intern Med. 1991;115(6):457-69.
Jacobi J. Pathophysiology of sepsis. Am J Health Syst Pharm. 2002;559 Suppl 1:S3-8.
DeLeo FR. Attractive shedding. Blood. 2007;110(6):1711-2.
Hurst SM, Wilkinson TS, McLoughlin RM, et al. IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity. 2001;14(6):705-14.
Ng PC1, Lee CH, Lam CW, et al. Resistin in preterm and term newborns: relation to anthropometry, leptin, and insulin. Pediatr Res. 2005;58(4):72530.
Kaser S, Kaser A, Sandhofer A, et al. Patsch Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro. Biochem Biophys Res Commun. 2003;309(2):286-90
Pang SS, Le YY. Role of resistin in inflammation and inflammation-related diseases. Cell Mol Immunol. 2006;3(1):29-34.
Konrad A, Lehrke M, Schachinger V, et al. Resistin is an inflammatory marker of inflammatory bowel disease in humans. Eur J Gastroenterol Hepatol. 2007;19(12):1070-4.
Adrych K, Smoczynski M, Sledzinski T, et al. Increased Serum Resistin Concentration in Patients With Chronic Pancreatitis: Possible Cause of Pancreatic Fibrosis. J Clin Gastroenterol. 2009;43(1):63-8.
Cekmez F, Canpolat FE, Cetinkaya M, et al. Diagnostic value of resistin and visfatin, in comparison with C-reactive protein, procalcitonin and interleukin-6 in neonatal sepsis. Eur Cytokine Netw. 2011;22(2):113-7.
Gursoy T, Aliefendioglu D, Caglayan O, et al. Resistin levels in preterms: are they influenced by fetal inflammatory course? J Perinatol. 2011;31(3):171-5.
Gokmen Z, Ozkiraz S, Kulaksizoglu S, et al. Resistin - a novel feature of sepsis in premature neonates. Am J Perinatol. 2013;30(6):513-7.