Prevalence of atopy in children with hypertrophic tonsil and recurrent/chronic tonsillitis

The incidence of allergic diseases is increasing every day. Many studies have been conducted to investigate the relationship between many diseases and the presence of atopy. However, there is not enough publication about the presence of atopy and a similar relationship between tonsil diseases. The aim of this study was to determine how hypertrophic, recurrent / chronic tonsils are affected by the presence of atopy. Study was conducted by produced from the thesis of Atopy Prevalence in Hypertrophic Tonsil and Recurrent / Chronic Tonsillitis Children. This study was carried out in Azerbaijan, Neriman Nerimanov Medical University, Department of Ear-Nose-Throat, on the children under the age of 15 years (minimum 2, largest 15 years, mean age 6.3). Tonsillectomy was diagnosed as recurrent / chronic tonsillitis or tonsillar hypertrophy and the first 50 patients were included in the study group and discussed with the literature. In our study, the presence of atopy in 50 children between the ages of 2-15 with tonsillar hypertrophy and recurrent / chronic tonsillitis was investigated. In 27 patients with advanced hypertrophic tendencies 7 (25.9%), in 23 patients with recurrent / chronic tonsillitis, atopy was detected in 1 (4.3%) and the difference was statistically significant. Serum total IgE levels were higher in patients with hypertrophic tonsil than patients with recurrent / chronic tonsillitis. This difference seems to be related to the high atopy rate seen in the hypertrophic tonsil group. As a result of these evaluations, it can be predicted that atopic patients may have hypertrophy in tonsils and atopy may be present in patients with tonsillar hypertrophy. Thus, tonsils may be one of the allergic organs such as lower respiratory tract, nose, skin, eye.

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1. Palmer MV, Thacker TC, Waters WR. Histology, immunohistochemistry and ultrastructure of the bovine palatine tonsil with special emphasis on reticular epithelium. Vet Immunol Immunopathol. 2009;127:277-85.

2. Steiniger B, Trabandt M, Barth PJ. Follicular dendritic cell network in secondary follicles of human palatine tonsils and spleens. Histochem Cell Biol. 2011;135:327–36.

3. Passàli D, Damiani V, Passàli GC, et al.Structural and immunological characteristics of chronically inflamed adenotonsillar tissue in childhood. Clin Diagn Lab Immunol. 2004;11:1154–7.

4. Sennaroğlu L, Onerci M, Hascelik G. The effect of tonsillectomy and adenoidectomy on neutrophil chemotaxis. Laryngoscope. 1993;103:1349-51.

5. Acar GO, Cansz H, Duman C, et al. Excessive reactive lymphoid hyperplasia in a child with persistent obstructive sleep apnea despite previous tonsillectomy and adenoidectomy. J Craniofac Surg. 2011;22:1413-5.

6. Erel F, Karaayvaz M, Caliskaner Z, et al. The allergen spectrum in Turkey and the relationships between allergens and age, sex, birth month, birth place, blood groups and family history of atopy. J Investing Allerg. Clin Immunol. 1998;8:226-33.

7. Hwang MS, Salapatas AM, Yalamanchali S, Joseph NJ, Friedman M. Factors Associated with Hypertrophy of the Lingual Tonsils. Otolaryngol Head Neck Surg. 2015;152:851-5.

8. Cummings W, Fredrickson JM, Harker LA, Krause CJ, Schüller DE. Pharyngitis and Adenotonsillar Disease (ed. Zalhal GH, Cotton RT.), Basic Allergy and Immunology (ed. Richtsmeier). Otolaryngology - Head and Neck Surgery., Mosby Year Book Inc., St. Louis, USA 1993. p. 1180-98.

9. Bykova VP, Satdykova GP. Morphofunctional organization of lymphoepithelial organs of the human pharynx. Izv Akad Nauk Ser Biol. 2002;4:463-71.

10. Kasımov E. Gulak Burun Boğaz Hestelikleri. Baku. 1992;167-85.

11. Brandtzaeg P. Immunology of tonsils and adenoids: everything the ENT surgeon needs to know. Int J Pediatr Otorhinolaryngol, 2003;6769-76.

12. 0stegaard PA. Tonsillar plasma IgE cells predict atopic disease. Clin Exp Immunol. 1982;49:163-6.

13. Altemanı A, Endo LH, Chone C, et al. Histopathological comparison between tonsil and adenoid responses to allergy. Acta Otolaryngol. 1996; 523:17-9.

14. Ramadan HH, Griffın JL, Adham R Prevalence of IgE mediated hypersensitivity in children with adonotonsillar disease Arch Otolaryngol Head Neck Surg. 1994:120:150-3.

15. Vinke JG, Fokkens WJ, De Jong SS, et al. Differences in cellular infiltrates in the adenoid of allergic children compared with age and gender - matched control. Clin Exp Allergy. 1998;28:187-95.

16. Gorfien JL, Hard R, Noble B, et al. Quantitative study of germinal center area in normal and diseased tonsils using image analysis. Ann Otol Rhinol Laryngol. 1999;108:349-402.

17. Dreborg S. Skin tests used in type-l allergy testing. Allergy. 1989;44:27.

18. Çelik G, Mungan D, Bavbek S, et al. The prevalence of allergic diseases and atopy in Ankara, Turkey: a two-step population-based epidemiological study J Astma. 1999;36:281-90.

19. Bailey BJ. Tonsillitis, Tonsillectomy and Adenoidectomy (Ed. Brodsky L.) Head &, Neck Surgery - Otolaryngology.; J. B. Lippincott Company, Philadelphia,1993. p. 833-47.

20. Harabuchi Y, Hamamato M, Shirasaki H, Asakura K, Matsuyama H, Kataura A. Specific immune response of the adenoids to a respiratory antigen . Am J Otolaryngol. 1989;10:138.

21. Levinson EW., Jawetz E. Medical Microbiology & Immunology. Hypersensitivity (Allergy). Prentice-Hall International Inc., New Jersey, 1992. p. 308-13.

22. Bergmann RL, Edenharter G, Bergmann KE, et al. Predictability of early atopy by cord blood-lgE and parental history. Clin Exp Allergy. 1997;27:752-60.

23. Kondo E, Yoshio T. Expression of apoptosis regulators in germinal centers and germinal center-derived B-cell lymphomas: insight into B-cell lymphomagenesis. Pathol Int. 2007;57:391-7.