Premature ovarian failure in autoimmune polyglandular syndrome

Premature ovarian failure in autoimmune polyglandular syndrome

Autoimmune polyglandular syndromes are a rare group of disorders of which Type II is the commonest. Premature ovarian failure is a minor feature of the disorder. The identification of the syndrome may take several years and different medical specialties need to be involved in the diagnosis and management of the case. The present case report describes the difficulties encountered in the diagnosis and successful management of a patient with the syndrome and its follow up. Some of the complications may be life threatening. Their work up and management becomes an expensive affair.

___

  • Neufeld M, Blizzard RM. Polyglandular autoimmune disease. In: Pinchera A, Doniach D, Fenzi GF, Baschieri L, eds, Symposium on autoimmune aspects of endocrine disorders, Acad Press, New York, 1981;357-65.
  • Eisenbarth GS, Gottlieb PA. Autoimmune polyendocrine syndromes. N Engl J Med. 2004;350:2068-79.
  • Bottazzo GF, Florin-Christensen A, Doniach D. Islet cell antibodies in Diabetes Mellitus with autoimmune polyendocrine deficiencies. Lancet. 1974;2:1279-83. de Graaff LC, Smit JW, Radder JK. Prevalence and clinical significance of organspecific autoantibodies in type 1 diabetes mellitus. Neth J Med. 2007;65(7):235-47. Förster G, Krummenauer F, Kühn I, Beyer J, Kahaly G. Polyglandular autoimmune syndrome type II: epidemiology and forms of manifestation. Dtsch Med Wochenschr. 1999;124(49):1476-81.
  • Obermayer-Straub P, Manns MP. Autoimmune polyglandular syndromes. Baillieres Clin Gastroenterol. 1998;12(2):293-15.
  • Cooper GS, Stroehla BC. The epidemiology of autoimmune diseases. Autoimmun Rev. May 2003;2(3):119-25.
  • Kauffman RP, Castracane VD. Premature ovarian failure associated with autoimmune polyglandular syndrome: pathophysiological mechanisms and future fertility. J Womens Health. 2003;12(5):513-20.
  • Betterle C, Lazzarotto, and Presotto F – Autoimmune polyglandular syndrome Type 2 – the tip of an iceberg? Clin Exp Immunol. 2004;137(2): 225-33.
  • Neufeld M, MacLaren, Blizzard RM. Two types of autoimmune diseases associated with different Polyglandular Syndromes. Medicine (Baltimore). 1981;60(5):355-62. Persson EB, Chapados I. An Unusual Cause of Primary Amenorrhea. Clin Pediatr (Phila). 2008;47(3):309-12.
  • Speroff L, Fritz MA. Clinical Gynecologic Endocrinology and Infertility 7th ed. LWW, New York, 2010;425-6.
Medicine Science-Cover
  • ISSN: 2147-0634
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2012
  • Yayıncı: Effect Publishing Agency ( EPA )