Organophosphate Poisoning and Cholinesterase Level: Case Report

Female patient forty four years old presented in the emergency department due to suicidal attempt with organophosphorous poisoning. The patient admitted to ICU and treated with atropine and obidoxim for two weeks. The patient improved clinically and discharged in a very good general condition but the ACH level does remain low. In this report I try to discuss this case.

___

1. Brunton LL, ed, Goodman and Gilman's The Pharmacological Basis of Theapeutics. 11th edition. New York; McGraw-Hill, 2006.

2. Pandit V, Seshadri S, Rao SN, Samarasinghe C, Kumar A, Valsalan R .A case of organophosphate poisoning presenting with seizure and unavailable history of parenteral suicide attempt. J Emerg Trauma Shock. 2011;4(1):132-4.

3. Yurumez Y, Durukan P, Yavuz Y, Ikizceli I, Avsarogullari L, Ozkan S, Akdur O, Ozdemir C, Acute organophosphate poisoning in university hospital emergency room patients. Intern Med. 2007;46(13):965-9.

4. Bertram G. Katzung, Basic and Clinical Pharmacology, The McGraw-Hill Companies, 10th edition, 2007.

5. MB Mycyk. Part 18. Poisoning, Drug Overdose, and Envenomation. In: DL Longo, AS Fauci, DL Kasper, SL Hauser, JL Jameson, J Loscalzo, eds, Harrison's Principles of Internal Medicine, 18th Edition. New York: McGraw-Hill Companies, 2012.

6. Wu ML, Deng JF, Tsai WJ, Ger J, Wong SS, Li HP. Food poisoning due to methamidophos-contaminated vegetables. J Toxicol Clin Toxicol. 2001;39(4):333-6.

7. United States Environmental Protection Agency. Organophosphate pesticide information. www.epa.gov/pesticides/op/chlorpyrifos/consumerqs.htm access date 03.05.2005

8. Buckley NA, Roberts D, Eddleston M. Overcoming apathy in research on organophosphate poisoning. BMJ. 2004;329(7476):1231-3.

9. Leibson T, Lifshitz M. Organophosphate and Carbamate Poisoning: Review of the Current Literature and Summary of Clinical and Laboratory Experience in Southern Israel. Isr Med Assoc J. 2008;10(11):767-70.

10. Eskenazi B, Bradman A, Castorina R. Exposures of Children to Organophosphate Pesticides and Their Potential Adverse Health Effects. Environmental Health Perspect. 199;107(3):409-19.

11. Nishijima DK. Toxicity, Organophosphate and Carbamate at eMedicine. http://emedicine.medscape.com/article/816221-overview access date 03.05.2015

12. Moore C. Children and Pollution: Why Scientists Disagree. Oxford University Press. 2009;109-12.

13. Eddleston M, Buckley NA, Eyer P, Dawson AH. Management of acute organophosphorus pesticide poisoning, Lancet. 2008;371(9612):597-607.

14. Roberts DM, Aaron CK, Management of acute organophosphorus pesticide poisoning BMJ. 2007;334(7594):629-34.

15. Eddleston M, Dawson A, Karalliedde L, Dissanayake W, Hittarage A, Azher S, Buckley NA. Early management after self-poisoning with an organophosphorus or carbamate pesticide-a treatment protocol for junior doctors. Crit Care. 2004;8(6):391- 7.

16. Balali-Mood M, Saber H, Recent advances in the treatment of organophosphorous poisonings., Iran J Med Sci. 2012;37(2):74-91.

17. Peter JV, Moran JL, Graham PL. Advances in the management of organophosphate poisoning. Expert Opin Pharmacother. 2007;8(10):1451-64.

18. Balali-Mood M, Balali-Mood K, Hosseini Shirazi F. Recent advances in treatment of acute organophosphorous nerve agents poisoning. Iran J Pharm Res. 2006;5(2):79-87.

19. Rahimi R, Nikfar S, Abdollahi M. Increased morbidity and mortality in acute human organophosphate-poisoned patients treated by oximes: a meta-analysis of clinical trials. Hum Exp Toxicol. 2006;25(3):157-62.

20. Peter JV, Moran JL, Graham P. Oxime therapy and outcomes in human organophosphate poisoning: an evaluation using meta-analytic techniques. Crit Care Med. 2006;34(2):502-10.

21. Kavya ST, Srinivas V, Chandana, Madhumati R. Clinical Profile of patients with Organophosphorus Poisoning in an Intensive Care Unit in a tertiary hospital. Int J Clin Cases Invest. 2012;4(3):24-31.

22. Chaudhary SC, Singh K, Sawlani KK, Jain N, Vaish AK, Atam V, Patel ML, Agarwal A. Prognostic significance of estimation of pseudocholinesterase activity and role of pralidoxime therapy in organophosphorous poisoning. Toxicol Int. 2013;20(3): 214-7.

23. Nouira S, Abroug F, Elatrous S, Boujdaria R, Bouchoucha S. Prognostic value of serum cholinesterase in organophosphate poisoning. Chest. 1994;106(6):1811-4.

24. Rajapakse BN, Thiermann H, Eyer P, Worek F, Bowe SJ, Dawson AH, Buckley NA. Evaluation of the Test-mate ChE (cholinesterase) field kit in acute organophosphorus poisoning. Ann Emerg Med. 2011;58(6):559-64.

25. Liu JH, Chou CY, Liu YL, Liao PY, Lin PW, Lin HH, Yang YF. Acid-base interpretation can be the predictor of outcome among patients with acute organophosphate poisoning before hospitalization. Am J Emerg Med. 2008;26(1):24- 30.
Medicine Science-Cover
  • ISSN: 2147-0634
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2012
  • Yayıncı: Effect Publishing Agency ( EPA )
Sayıdaki Diğer Makaleler

Organophosphate Poisoning and Cholinesterase Level: Case Report

Hashem M. MANSOUR

[Preterm Prematür Erken Membran Rüptürü (Pprom) Ve Preterm Eylem (Pte)'De Doğuma Kadar Geçen Süreyi Belirleyebilir Miyiz?

Turhan CAGLARL, Nuri DANİSMA, Dilek UYGURL, Sibel SAYGAN, Sibel ÖZLER, Derya SOLMAZL, Efser OZTASL

İnönü Üniversitesi Tıp Fakültesi Öğrencilerinin Engellilere Yönelik Tutum Ve Davranışları

Ayse GOKCE, GÜLSEN GÜNEŞ, Duygu SEYİTOGLU ÇELİK

Targeted Agents in Ovarian Carcinoma

Murat ÖZ, İlker SELÇUK, Zafer ARIK, Tayfun GÜNGÖR

Pancreatic Involvement of Burkitt Lymphoma in a Child and Review of the Literature

Simge KAYA, Elvan Çağlar ÇITAK, Yasemin KARABULUT, Eda Bengi YILMAZ, Demir APAYDIN

Closure of tympanic membrane perforations using repeated trichloracetic acid

Özer Erdem GÜR, SERDAR ENSARİ, Nevreste Didem SONBAY, Nuray ENSARİ, Serdar ÇELİKKANAT, Osman Fatih BOZTEPE

An Atypical Case of Lumbar Scheuermann's Disease

Murat KARADENİZ, Ozgur DANDİN, Taner DANDİNOGLU

Large Predominantly Solid Variant of Aneurysmal Bone Cyst in the Diaphysis of Femur: A Rare Entity

Seema ROHILLA, Manik MAHAJAN, Poonam SHARMA, Zile Singh KUNDU, Rohtas K. YADAV, Puneet GUPTA

Can Obstructive Sleep Apnea Syndrome be Associated with Urinary Symptoms and Erectile Dysfunction

Soner COBAN, HAYDAR KAMİL ÇAM, EGE GÜLEÇ BALBAY, Ali TEKİN, Balbay ONER, Muhammet Ali KAYIKÇI

May Lymphadenectomy be Omitted in Granulosa Cell Tumors of the Ovary?

Murat ÖZ, İlker SELÇUK, Bülent ÖZDAL, Ebru BİBEROĞLU, Sevda BAŞ, Mehmet Mutlu MEYDANL, Serap AKBAY, Tayfun GÜNGÖR