Hashem M. MANSOUR

Organophosphate Poisoning and Cholinesterase Level: Case Report

Female patient forty four years old presented in the emergency department due to suicidal attempt with organophosphorous poisoning. The patient admitted to ICU and treated with atropine and obidoxim for two weeks. The patient improved clinically and discharged in a very good general condition but the ACH level does remain low. In this report I try to discuss this case.

PDF

___

1. Brunton LL, ed, Goodman and Gilman's The Pharmacological Basis of Theapeutics. 11th edition. New York; McGraw-Hill, 2006.

2. Pandit V, Seshadri S, Rao SN, Samarasinghe C, Kumar A, Valsalan R .A case of organophosphate poisoning presenting with seizure and unavailable history of parenteral suicide attempt. J Emerg Trauma Shock. 2011;4(1):132-4.

3. Yurumez Y, Durukan P, Yavuz Y, Ikizceli I, Avsarogullari L, Ozkan S, Akdur O, Ozdemir C, Acute organophosphate poisoning in university hospital emergency room patients. Intern Med. 2007;46(13):965-9.

4. Bertram G. Katzung, Basic and Clinical Pharmacology, The McGraw-Hill Companies, 10th edition, 2007.

5. MB Mycyk. Part 18. Poisoning, Drug Overdose, and Envenomation. In: DL Longo, AS Fauci, DL Kasper, SL Hauser, JL Jameson, J Loscalzo, eds, Harrison's Principles of Internal Medicine, 18th Edition. New York: McGraw-Hill Companies, 2012.

6. Wu ML, Deng JF, Tsai WJ, Ger J, Wong SS, Li HP. Food poisoning due to methamidophos-contaminated vegetables. J Toxicol Clin Toxicol. 2001;39(4):333-6.

7. United States Environmental Protection Agency. Organophosphate pesticide information. www.epa.gov/pesticides/op/chlorpyrifos/consumerqs.htm access date 03.05.2005

8. Buckley NA, Roberts D, Eddleston M. Overcoming apathy in research on organophosphate poisoning. BMJ. 2004;329(7476):1231-3.

9. Leibson T, Lifshitz M. Organophosphate and Carbamate Poisoning: Review of the Current Literature and Summary of Clinical and Laboratory Experience in Southern Israel. Isr Med Assoc J. 2008;10(11):767-70.

10. Eskenazi B, Bradman A, Castorina R. Exposures of Children to Organophosphate Pesticides and Their Potential Adverse Health Effects. Environmental Health Perspect. 199;107(3):409-19.

11. Nishijima DK. Toxicity, Organophosphate and Carbamate at eMedicine. http://emedicine.medscape.com/article/816221-overview access date 03.05.2015

12. Moore C. Children and Pollution: Why Scientists Disagree. Oxford University Press. 2009;109-12.

13. Eddleston M, Buckley NA, Eyer P, Dawson AH. Management of acute organophosphorus pesticide poisoning, Lancet. 2008;371(9612):597-607.

14. Roberts DM, Aaron CK, Management of acute organophosphorus pesticide poisoning BMJ. 2007;334(7594):629-34.

15. Eddleston M, Dawson A, Karalliedde L, Dissanayake W, Hittarage A, Azher S, Buckley NA. Early management after self-poisoning with an organophosphorus or carbamate pesticide-a treatment protocol for junior doctors. Crit Care. 2004;8(6):391- 7.

16. Balali-Mood M, Saber H, Recent advances in the treatment of organophosphorous poisonings., Iran J Med Sci. 2012;37(2):74-91.

17. Peter JV, Moran JL, Graham PL. Advances in the management of organophosphate poisoning. Expert Opin Pharmacother. 2007;8(10):1451-64.

18. Balali-Mood M, Balali-Mood K, Hosseini Shirazi F. Recent advances in treatment of acute organophosphorous nerve agents poisoning. Iran J Pharm Res. 2006;5(2):79-87.

19. Rahimi R, Nikfar S, Abdollahi M. Increased morbidity and mortality in acute human organophosphate-poisoned patients treated by oximes: a meta-analysis of clinical trials. Hum Exp Toxicol. 2006;25(3):157-62.

20. Peter JV, Moran JL, Graham P. Oxime therapy and outcomes in human organophosphate poisoning: an evaluation using meta-analytic techniques. Crit Care Med. 2006;34(2):502-10.

21. Kavya ST, Srinivas V, Chandana, Madhumati R. Clinical Profile of patients with Organophosphorus Poisoning in an Intensive Care Unit in a tertiary hospital. Int J Clin Cases Invest. 2012;4(3):24-31.

22. Chaudhary SC, Singh K, Sawlani KK, Jain N, Vaish AK, Atam V, Patel ML, Agarwal A. Prognostic significance of estimation of pseudocholinesterase activity and role of pralidoxime therapy in organophosphorous poisoning. Toxicol Int. 2013;20(3): 214-7.

23. Nouira S, Abroug F, Elatrous S, Boujdaria R, Bouchoucha S. Prognostic value of serum cholinesterase in organophosphate poisoning. Chest. 1994;106(6):1811-4.

24. Rajapakse BN, Thiermann H, Eyer P, Worek F, Bowe SJ, Dawson AH, Buckley NA. Evaluation of the Test-mate ChE (cholinesterase) field kit in acute organophosphorus poisoning. Ann Emerg Med. 2011;58(6):559-64.

25. Liu JH, Chou CY, Liu YL, Liao PY, Lin PW, Lin HH, Yang YF. Acid-base interpretation can be the predictor of outcome among patients with acute organophosphate poisoning before hospitalization. Am J Emerg Med. 2008;26(1):24- 30.