Niacin: Does It affect 8-hydroxy-2-deoxyguanosine levels of the patients having low HDL cholesterol levels?

Niacin: Does It affect 8-hydroxy-2-deoxyguanosine levels of the patients having low HDL cholesterol levels?

We aimed to determine whether niacin improve plasma HDL-cholesterol levels by decreasing 8-Hydroxydeoxyguanosıne (8-OHdG) as a biomarker of oxidative DNA damage or not. Patients (n=32) with low HDL-cholesterol levels (40 mg/dl) were included in the study. Lipoprotein profiles (total cholesterol, HDL-C, and total triglycerides) were measured in all patients. LDL-C was calculated as described by Friedewald et al. Before and after 16 week of niacin therapy serum 8-OHdG was measured. There were significant difference between pre and post treatment plasma HDL-C and 8-OHdG levels. We concluded that niacin may raise HDL-C levels. The improvement of plasma HDL-C levels may have a protective effect on endothelial dysfunction. By reducing the level of 8-OHdG, niacin may decrease DNA damage. Thus, niacin therapy may be consider as an alternative to statins or fibrates in patients in whom fail to sufficiently correct low HDL-C levels.

___

  • Meyers CD, Kamanna VS, Kashyap ML. Niacin therapy in atherosclerosis. Curr Opin Lipidol. 2004;15(6):659-65.
  • Kamanna VS, Kashyap ML. Mechanism of action of niacin on lipoprotein metabolism. Curr Atheroscler Rep. 2000;2(1):36-46.
  • Singh V, Sharma R, Kumar A, Deedwania P. Low high-density lipoprotein cholesterol: current status and future strategies for management. Vasc Health Risk Manag. 2010;29(6):979-96.
  • Wu BJ, Yan L, Charlton F, Witting P, Barter PJ, Rye KA. Evidence that niacin inhibits acute vascular inflammation and improves endothelial dysfunction independent of changes in plasma lipids. Arterioscler Thromb Vasc Biol. 2010;30(5):968-75.
  • Lee K, Ahn TH, Kang WC, Han SH, Choi IS, Shin EK. The effects of statin and niacin on plaque stability, plaque regression, inflammation and oxidative stres in patients with mild to moderate coronary artery stenosis. Korean Circ J. 2011;41(11):641-8.
  • Wu BJ, Chen K, Barter PJ, Rye KA. Niacin inhibits vascular inflammation via the induction of heme oxygenase-1. Curr Atheroscler Rep. 2012;14(1):49-59. Canner PL, Berge KG, Wenger NK, Stamler J, Friedman L, Prineas RJ, Friedewald W. Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin. J Am Coll Cardiol. 1986;8(6):1245-55.
  • Knopp RH, Retzlaff BM, Fish B, Dowdy A, Twaddell B, Nguyen T, Paramsothy P. The SLIM Study: Slo-Niacin® and Atorvastatin Treatment of Lipoproteins and Inflammatory Markers in Combined Hyperlipidemia. J Clin Lipidol. 2009;3(3):167
  • AIM-HIGH: Niacin plus Statin to Prevent Vascular Events. Accessed at http://clinicaltrials.gov/ct2/show/NCT00120289
  • HPS2-THRIVE: A Randomized Trial of the Long-term Clinical Effects of Raising HDL Cholesterol With Extended Release Niacin/Laropiprant. Accessed at http://clinicaltrials.gov/ct2/show/NCT00461630
Medicine Science-Cover
  • ISSN: 2147-0634
  • Yayın Aralığı: 4
  • Başlangıç: 2012
  • Yayıncı: Effect Publishing Agency ( EPA )
Sayıdaki Diğer Makaleler

Relationship of Glutathione Status with Oral Pre-cancer and Cancer

Shishir Ram Shetty, Subhas G Babu, Sucheta Kumari, Pushparaja Shetty, Radhakrishna Vijay, Arvind Karikal

A Case of Choanal Polyp Originating From the Superior Nasal Concha

Mehmet KELLEŞ, İsrafil ORHAN, Selman Sarıca, Mehmet Fatih İnci

Assessment the Levels of Knowledge and Awareness about Organ and Tissue Donation among The Staff of Ministry of Health Ordu University Training and Research Hospital

Özgür ENGİNYURT, Nilay TAŞ, Erdal ÖZER

Cholesterol Lowering Effect of Subchronic Inhalation Particulate Matter 10 Coal Dust on Rats

Bambang SETİAWAN, Asnawati DARSUNİ, Fauzan MUTTAQİEN, M Aris WİDODO

Evaluation of Honour Killings in Turkey

Osman CELBİS, Bora OZDEMİR, Mucahit ORUC, Mustafa DOGAN, Mucahit EGRİ

HIV and Preconception- a Review

Divya Hegde, Priya Kamath, Latha Sharma

Investigating the Efficacy and Safety of Silymarin in Management of Hyperbilirubinemia in Neonatal Jaundice

Lamyaa M. Kassem, Mohamed EA Abdelrahim, Hassan F. Naguib

The Effect of the Serum Amino Acid Levels Thiosemicarbazone Derivatives and its Metal Complexes on Rats

Mustafa Karatepe, Dilara Kaman

Should FISH Test be Performed to all Patients With Breast Cancer?

Hasan MUTLU, Halit KARACA, Zeki AKCA, Yasemin Altuner TORUN, Abdülsamet ERDEN, Tuncay ASLAN, Abdullah BÜYÜKÇELİK

Intraoperative Anaphylactic Shock Due To Latex Allergy: Case Report

Mustafa Said AYDOGAN, Ulkü OZGÜL, Mehmet Ali ERDOĞAN, Nurcin GÜLHAS, Hüseyin İlksen TOPRAK, Mahmut DURMUS