Evaluation of the effect of obesity on fibromyalgia in premenopausal female patients

Obesity is a chronic disease whose prevalence is increasing all over the world. The relationship between obesity and some rheumatic diseases such as Fibromyalgia Syndrome (FMS) has recently attracted attention. In this study, we investigated the effect of obesity on FMS in premenopausal female patients. Anamnesis, physical examination and laboratory data obtained from 103 female patients who were divided into two groups as obese and non-obese according to body mass index (BMI) were statistically analyzed in terms of FMS. 25.2% of the women participating in the study were diagnosed with FMS, and the mean age of the cases was 33.42 (± 10.41), the mean weight was 79.65 (± 19.91), and the mean BMI was 30.52 (± 7.75). The mean age of the obese was higher 38.48 (± 8.95) and the incidence of obesity was significantly higher with age (p ˂ 0.001). The frequency of FMS (p = 0.001), Fibromyalgia Impact Questionnaire results (p = 0.001) and tender point numbers in the Widespread Pain Index Scale (p ˂ 0.001) were significantly higher in the obese group. There was no statistically significant difference between the obese and non-obese groups in terms of marital status, occupation, smoking history and education levels. Obesity prevalence is increasing all over the world and the results of the present study reveal FMS complications are getting worse by obesity. Therefore, prevention and medical treatment of obesity, can positively affect many parameters in the body and reduce the incidence of FMS.

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1. Tchang BG, Saunders KH, Igel LI. Best practices in the management of overweight and obesity. Med Clin North Am. 2021;105:149–74.
2. D’Onghia M, Ciaffi J, Lisi L, et al. Fibromyalgia and obesity: A comprehensive systematic review and meta-analysis. Semin Arthritis Rheum. 2021;51:409–24.
3. Rodríguez-Roca B, Urcola-Pardo F, Anguas-Gracia A, et al. Impact of reducing sitting time in women with fibromyalgia and obesity: a randomized controlled trial. Int J Environ Res Public Health. 2021;18.
4. Singh JA, Saag KG, Bridges SL, et al. 2015 American college of rheumatology guideline for the treatment of rheumatoid arthritis. Arthritis Rheumatol. 2016;68:1–26.
5. Sarmer S, Ergin S, Yavuzer G. The validity and reliability of the Turkish version of the Fibromyalgia Impact Questionnaire. Rheumatol Int. 2000;20:9–12.
6. Zheng H, Chen C. Body mass index and risk of knee osteoarthritis: systematic review and meta-analysis of prospective studies. BMJ Open. 2015 1;5:e007568.
7. Mansoor S, Siddiqui M, Mateen F, et al. Prevalence of obesity in carpal tunnel syndrome patients: a cross-sectional survey. Cureus. 2017;26;9.
8. Zhang TT, Liu Z, Liu YL, et al. Obesity as a risk factor for low back pain. Clin Spine Surg. 2018;31:22–7.
9. Arreghini M, Manzoni GM, Castelnuovo G, et al. Impact of fibromyalgia on functioning in obese patients undergoing comprehensive rehabilitation. PLoS ONE. 2014;9:91392.
10. Arnold LM, Clauw DJ. Challenges of implementing fibromyalgia treatment guidelines in current clinical practice. Postgrad Mede. 2017;129:709–14.
11. Topbas M, Cakirbay H, Gulec H, et al. The prevalence of fibromyalgia in women aged 20-64 in Turkey. Scand J Rheumatol. 2005;34:140–4.
12. Cakirbay H, Cebi A, Cebi E, et al. Risk factors of fibromyalgia in Turkish women. Pain Clin. 2006 5;18:251–7.
13. Saber AA, Boros MJ, Mancl T, et al. The effect of laparoscopic roux-en-y gastric bypass on fibromyalgia. Obes Surg. 2008;18:652–5.
14. Gota CE, Kaouk S, Wilke WS. Fibromyalgia and obesity: The association between body mass index and disability, depression, history of abuse, medications, and comorbidities. J Clin Rheumatol. 2015;21:289–95
15. Bennett RM, Jones J, Turk DC, et al. An internet survey of 2,596 people with fibromyalgia. BMC Musculoskeletal Disord. 2007;8:1–11.
16. Neumann L, Lerner E, Glazer Y, et al. A cross-sectional study of the relationship between body mass index and clinical characteristics, tenderness measures, quality of life, and physical functioning in fibromyalgia patients. Clin Rheumatol. 2008;27:1543–7.
17. Okifuji A, Bradshaw DH, Olson C. Evaluating obesity in fibromyalgia: neuroendocrine biomarkers, symptoms, and functions. Clin Rheumatol. 2009;28:475–8.
18. Yunus MB, Arslan S, Aldag JC. Scandinavian Journal of Rheumatology Relationship between body mass index and fibromyalgia features. Scand J Rheumatol. 2002;31:27–31.
19. Han T, Seidell J, Currall J, et al. The influences of height and age on waist circumference as an index of adiposity in adults. Int J Obes Relat Metab Disord. 1997;21:83–9.
20. Seidell JC, Bakx KC, Deurenberg P, et al. The relation between overweight and subjective health according to age, social class, slimming behaviour and smoking habits in Dutch adults. Am J Public Health. 2011;76:1410–5.
21. Ulas B, Genç MF. The Attitude and Behaviours of the Personnel on Duty at Malatya Military Hospital in 2007 on Healthy Dieting. Ann Med Res. 2010;17:0187–93.
22. Gunes G, Genc M, Pehlivan E. Obesity in adult women in Yesilyurt Health Center Region. J Turgut Ozal Med Center. 2000;7:48–53.
23. Mork PJ, Vasseljen O, Nilsen TIL. Association between physical exercise, body mass index, and risk of fibromyalgia: longitudinal data from the norwegian nord-trøndelag health study. Arthritis Care Res [Internet]. 2010;62:611–7.
24. Kocyigit BF, Okyay RA. The rela tionship between body mass index and pain, disease activity, depression and anxiety in women with fibromyalgia. PeerJ. 2018 28;6:e4917.
25. Ursini F, Naty S, Grembiale RD. Fibromyalgia and obesity: the hidden link. Rheumatol Int. 2011;31:1403–8.
26. Henriksson CM. Longterm Effects of Fibromyalgia on Everyday Life: A Study of 56 Patients. Scand J Rheumatol. 1994;23:36–41.
27. Algul A, Alpay Ates M, Basar Semiz U, et al. Evaluation of general psychopathology, subjective sleep quality, and health-related quality of life in patients with obesity. Psychiatr Med. 2009;39:297–312.
28. Gadalla TM. Association of obesity with mood and anxiety disorders in the adult general population. Chronic Dis Can. 2009;30:28–35.
29. Soy M, Guldiken S, Arikan E, et al. Frequency of rheumatic diseases in patients with autoimmune thyroid disease. Rheumatol Int. 2007;27:575–7.
30. Bennett RM, Cook DM, Clark SR, et al. Hypothalamic-pituitary-insulinlike growth factor-I axis dysfunction in patients with fibromyalgia. J Rheumatol. 1997;24:1384–9.
31. Bennett RM, Clark SR, Campbell SM, et al. Arthritis & Rheumatism. Low levels of somatomedin c in patients with fibromyalgia syndrome a possible link between sleep and muscle pain. Arthritis Rheum. 1992;35:1113–6.
32. Maccario M, Grottoli S, Procopio M, et al. The GH an IGF-I axis in obesity: influence of neuroendocrine and metabolic factors. Int J Obes. 2000;Suppl 2:S96-9.
33. Cuatrecasas G, Riudavets C, Güell MA, Nadal A. Growth hormone as concomitant treatment in severe fibromyalgia associated with low IGF-1 serum levels. A pilot study. BMC Musculoskelet Disord. 2007 30;8:119.
34. Genc H, Atasever M, Duyur Cakit B, et al. The Effects of Fibromyalgia Syndrome on Physical Function and Psychological Status of Pregnant Females. Arch Rheumatol. 2017;32:129–40.
35. Thielman J, Harrington D, Rosella LC, et al. Prevalence of age-specific and sex-specific overweight and obesity in Ontario and Quebec, Canada: a cross-sectional study using direct measures of height and weight. BMJ Open. 2018;8:e022029.
36. Tishler M, Smorodin T, Vazina-Amit M, et al. Fibromyalgia in diabetes mellitus. Rheumatol Int. 2003;23:171–3.
37. Lichtenstein A, Tiosano S, Comaneshter D, et al. Cross-sectional analysis of the associations between fibromyalgia and diabetes mellitus. Reumatologia. 2018;56:275–8.
38. Benlidayi IC. Role of inflammation in the pathogenesis and treatment of fibromyalgia. Rheumatol Int. 2019;39:781–91.
39. Dogru A, Balkarli A, Cobankara V, et al. Effects of Vitamin D therapy on quality of life in patients with fibromyalgia. Eurasian J Med. 2017 6;49:113–7.
40. Haliloglu S, Ekinci B, Uzkeser H, et al. Fibromyalgia in patients with thyroid autoimmunity: prevalence and relationship with disease activity. Clin Rheumatol. 2017;36:1617–21.
41. Sonsuz A. Fatty Liver Disease. In: Goksoy E, editor. Clinical Approach in Gastroenterology Symposium Series No:38 Istanbul University Cerrahpaşa Faculty of Medicine. Istanbul: DEOMED; 2004. p. 171–80.
42. Gurbuz A. A Research on Bone Formation and Destruction Markers and Their Relationship with Osteoporosis in Patients with Fibromyalgia Syndrome. [Elazig];2017. PhD Thesis.
43. Kaya A, Kamanli A, Saitoglu M, et al. Serum lipid profile in patients with myofascial pain syndrome. Firat Med J. 2006;11:160–16.
44. Ozkahraman S, Kisioglu AN, Ozturk M. The prevalence of obesity in married women aged 15-49 in a health centre region and the effect of education on knowledge, attitude, behaviour and prevalence of obesity. In: 8th National Public Health Congress Congress. 2002. p. 738–40.
45. Efil S. Investigation of obesity frequency and its factors among health workers. Afyon Kocatepe University, Health Sciences Institute, Internal Medicine Nursing Department. Master's Thesis [Afyon]; 2005.