Evaluation of serum perlecan levels in pregnancy with mild and severe preeclampsia

Evaluation of serum perlecan levels in pregnancy with mild and severe preeclampsia

In this study, we aimed to determine the levels of perlecan contributing to autophagy inhibition and angiogenesis in severe and mild preeclamptic women. A total of 89 patients including severe preeclampsia, group 1 (n:30), mild preeeclampsia, group 2 (n:30) and control group, group 3 (n:29) were included in the study. All three groups were evaluated in terms of perlecan levels. Perlecan level in group 1 was determined at higher levels than other groups, and this level difference was statistically significant compared to the other two groups (p

___

  • 1. El-Sayed AAF. Preeclampsia: A review of the pathogenesis and possible management strategies based on its pathophysiological derangements. Taiwan J Obstet Gynecol. 2017;56:593-8.
  • 2. Abalos E, Cuesta C, Grosso AL, et al. Global and regional estimates of preeclampsia and eclampsia: A systematic review. Eur J Obstet Gynecol Reprod Biol. 2013;170:1-7.
  • 3. Karumanchi SA, Bdolah Y. Hypoxia and sFlt-1 in preeclampsia: The “chickenand-egg” question. Endocrinology. 2004;145:4835-7.
  • 4. Jiang X, Couchman JR. Perlecan and tumor angiogenesis. J Histochem Cytochem. 2003;51:1393-410.
  • 5. Ning L, Xu Z, Furuya N, et al. Perlecan inhibits autophagy to maintain muscle homeostasis in mouse soleus muscle. Matrix Biol. 2015;48:26-35.
  • 6. Gubbiotti MA, Neill T, Iozzo RV. A current view of perlecan in physiology and pathology: A mosaic of functions. Matrix Biol. 2017;57-58:285-98.
  • 7. Vuadens F, Benay C, Crettaz D, et al. Identification of biologic markers of the prematüre rupture of fetal membranes: Proteomic approach. Proteomics. 2003;3:1521-5.
  • 8. Akbas M, Koyuncu FM, Ulkumen BA, et al. Maternal serum perlecan levels in women with preeclampsia. Hypertens Pregnancy. 2020;39:70-6.
  • 9. Szenasi NL, Toth E, Balogh A, et al. Proteomic identification of membraneassociated placental protein 4 (MP4) as perlecan and characterization of its placental expression in normal and pathologic pregnancies. Peer J. 2019;20;7:e6982.
  • 10. Yang WC, Su TH, Yang YC, et al. Altered perlecan expression in placental development and gestational diabetes mellitus. Placenta. 2005;26:780–8.
  • 11. Chui A, Murthi P, Brennecke SP, et al. The expression of placental proteoglycans in pre-eclampsia. Gynecol Obstet Invest. 2012;73:277-84.
  • 12. Zhao H, Gong L, Wu S, et al. The inhibition of protein kinase C β contributes to the pathogenesis of preeclampsia by activating autophagy E Bio Medicine. 2020;56:102813.
  • 13. Du J, Ji Q, Dong L, et al. HDAC4 knockdown induces preeclampsia cell autophagy and apoptosis by miR-29b. Reprod Sci. 2021;28:334-42.
  • 14. Cornelius DC, Wallace K. Autophagy in preeclampsia: A new target? E Bio Medicine. 2020;57:102864.
  • 15. Nakashima A, Aoki A, Kusabiraki T, et al. Autophagy regulation in preeclampsia: Pros and cons. J Reprod Immunol. 2017;123:17-23.
Medicine Science-Cover
  • ISSN: 2147-0634
  • Yayın Aralığı: 4
  • Başlangıç: 2012
  • Yayıncı: Effect Publishing Agency ( EPA )
Sayıdaki Diğer Makaleler

Bilateral ossified subdural hematoma: Literature review

Nermin Tanik, Sevilay Vural, Hakan Ak, Ihsan Canbek

What is the role of intoxication cases in the intensive care workload during the pandemic period?

Ahmet Yuksek, Okkes Hakan Miniksar, Mustafa Enes Demirel

Disease activation and laboratory parameters in Fibromyalgia Syndrome: Relationship with C-reactive protein/albumin ratio, neutrophil/lymphocyte ratio, mean platelet volume

Rabia Aydogan Baykara, Tugba Izci Duran, Melih Pamukcu

Evaluation of smell and taste dysfunctions concurrent otolaryngological symptoms in SARS-CoV-2 positive patients

Cigdem Firat Koca

Do cytokines play role in the pathogenesis of mucopolysaccharidosis

Gursel Biberoglu, Asli Inci, Ilyas Okur, Leyla Tumer, Fatih Suheyl Ezgu, Canan Demirtas

Respiratory viruses in hospitalized children with acute respiratory infections at 2019-2020 autumn-winter season: A single-center experience before COVID-19 pandemic

Mursit Hasbek, Ayca Komurluoglu Tan

Evaluation of serum perlecan levels in pregnancy with mild and severe preeclampsia

Tufan Arslanca, Muhammed Seyi̇thanoglu, Ugurkan Erkayiran, Abdullah Tok, Seli̇m Karakucuk

The comparison of telomere length in cancer patients: Plasma, whole blood and tumor tissue

Fatma Silan, Ozturk ÖZDEMİR, Furkan Erturk Urfali, Mine Urfali, Atila Gurgen

Frequency and predictors of coronavirus anxiety in psychiatric patients and healthy people and its effect on treatment compliance during the pandemic

Nesihan Cansel, Ahmet ÜNAL, Mustafa Akan, Lale Gonenir Erbay, Saadet Ekici Onsoz, Sahide Nur Ipek Melez

The effects of some characteristics of women and menopause symptoms on menopausal attitude

Ummuhan Akturk, Sumeyye Yagmur