Evaluation of serum perlecan levels in pregnancy with mild and severe preeclampsia
Evaluation of serum perlecan levels in pregnancy with mild and severe preeclampsia
In this study, we aimed to determine the levels of perlecan contributing to autophagy inhibition and angiogenesis in severe and mild preeclamptic women. A total of 89 patients including severe preeclampsia, group 1 (n:30), mild preeeclampsia, group 2 (n:30) and control group, group 3 (n:29) were included in the study. All three groups were evaluated in terms of perlecan levels. Perlecan level in group 1 was determined at higher levels than other groups, and this level difference was statistically significant compared to the other two groups (p
___
- 1. El-Sayed AAF. Preeclampsia: A review of the pathogenesis and possible management strategies based on its pathophysiological derangements. Taiwan J Obstet Gynecol. 2017;56:593-8.
- 2. Abalos E, Cuesta C, Grosso AL, et al. Global and regional estimates of preeclampsia and eclampsia: A systematic review. Eur J Obstet Gynecol Reprod Biol. 2013;170:1-7.
- 3. Karumanchi SA, Bdolah Y. Hypoxia and sFlt-1 in preeclampsia: The “chickenand-egg” question. Endocrinology. 2004;145:4835-7.
- 4. Jiang X, Couchman JR. Perlecan and tumor angiogenesis. J Histochem Cytochem. 2003;51:1393-410.
- 5. Ning L, Xu Z, Furuya N, et al. Perlecan inhibits autophagy to maintain muscle homeostasis in mouse soleus muscle. Matrix Biol. 2015;48:26-35.
- 6. Gubbiotti MA, Neill T, Iozzo RV. A current view of perlecan in physiology and pathology: A mosaic of functions. Matrix Biol. 2017;57-58:285-98.
- 7. Vuadens F, Benay C, Crettaz D, et al. Identification of biologic markers of the prematüre rupture of fetal membranes: Proteomic approach. Proteomics. 2003;3:1521-5.
- 8. Akbas M, Koyuncu FM, Ulkumen BA, et al. Maternal serum perlecan levels in women with preeclampsia. Hypertens Pregnancy. 2020;39:70-6.
- 9. Szenasi NL, Toth E, Balogh A, et al. Proteomic identification of membraneassociated placental protein 4 (MP4) as perlecan and characterization of its placental expression in normal and pathologic pregnancies. Peer J. 2019;20;7:e6982.
- 10. Yang WC, Su TH, Yang YC, et al. Altered perlecan expression in placental development and gestational diabetes mellitus. Placenta. 2005;26:780–8.
- 11. Chui A, Murthi P, Brennecke SP, et al. The expression of placental proteoglycans in pre-eclampsia. Gynecol Obstet Invest. 2012;73:277-84.
- 12. Zhao H, Gong L, Wu S, et al. The inhibition of protein kinase C β contributes to the pathogenesis of preeclampsia by activating autophagy E Bio Medicine. 2020;56:102813.
- 13. Du J, Ji Q, Dong L, et al. HDAC4 knockdown induces preeclampsia cell autophagy and apoptosis by miR-29b. Reprod Sci. 2021;28:334-42.
- 14. Cornelius DC, Wallace K. Autophagy in preeclampsia: A new target? E Bio Medicine. 2020;57:102864.
- 15. Nakashima A, Aoki A, Kusabiraki T, et al. Autophagy regulation in preeclampsia: Pros and cons. J Reprod Immunol. 2017;123:17-23.