Does zinc supplementation affect the clinical healing process of stress fracture?

Does zinc supplementation affect the clinical healing process of stress fracture?

Monitoring levels of local pain and weight-bearing are important subjective data used for clinical follow-up of fracture healing, in the foot stress fractures (SFs). Medical treatment has been focused on vitamin D and calcium intake, hovewer there has been no study on the effect of zinc for this fractures. The purpose of this study was to investigate the effectiveness of zinc supplementation on the clinical healing process of SFs in foot. We retrospectively analysed patients with stress fracture in foot. Patients divided into two groups as those who used oral zinc supplementation (group 1) (n=43) and did not use (group 2) (n=52) during clinical healin process. The clinical healing process of the patients were monitored with the Visual Analogue Scale (VAS) scoring system and time to painless Weight Bearing (WB) on the fracture site. The data of the patients were recorded at intervals of three weeks for up to six months. There was a significant difference between the groups according to the mean VAS pain score in the first three months (p

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  • 1. Shindle MK, Endo Y, Warren RF, et al. Stress fractures about the tibia, foot and ankle. J Am Acad Orthop Surg. 2012;20:167-76.
  • 2. Moreira CA, Bilezikian JP. Stress fractures: concepts and therapeutics. J Clin Endocrinol Metab. 2017;102:525-34.
  • 3. Martínez-Silván D, Wik EH, Alonso JM, Jeanguyot E, et al. Injury characteristics in male youth athletics: a five-season prospective study in a full-time sports academy. Br J Sports Med. 2020;55:954–60.
  • 4. Dao D, Sodhi S, Tabasinejad R, et al. Serum 25-hydroxyvitamin D levels and stress fractures in military personnel: A systematic review and metaanalysis. Am J Sports Med. 2014:43:2064–72.
  • 5. Atik OS, Uslu MM, Eksioglu F, et al. Etiology of senile osteoporosis: a hypothesis. Clin Orthop Relat Res. 2006;443:25-7.
  • 6. Lim KHC, Riddell LJ, Nowson CA, et al. Iron and zinc nutrition in the economically-developed world: a review. Nutrients. 2013;5:3184-211.
  • 7. Barceloux, DG. Zinc. J Toxicol Clin Toxicol. 1999;37:279–92.
  • 8. Yamaguchi M. Role of nutritional zinc in the prevention of osteoporosis. Mol Cell Biochem. 2010;338:241–54.
  • 9. O’Connor JP, Kanjilal D, Teitelbaum M, et al. Zinc as a Therapeutic Agent in Bone Regeneration. Materials (Basel). 2020:13;2211-32.
  • 10. Morshed S, Corrales L, Genant H, et al. Outcome assessment in clinical trials of fracture-healing. J Bone Joint Surg Am. 2008;90(Suppl 1):62–7.
  • 11. Inci A, Ergin FBC, Yuce BT, et al. Hypophosphatasia: is it an underdiagnosed disease even by expert physicians? J Bone Miner Metab. 2021 39:598-605.
  • 12. Ozdemir G, Kilic E, Andic K, et al. Bilateral stress fractures of pubic ramus in a patient affected by hyperparathyroidism. Mathews J Case Rep. 2017;2:026.
  • 13. Bijur PE, Silver W, Gallagher EJ. Reliability of the visual analog scale for measurement of acute pain. Acad Emerg Med. 2001;8:1153-7.
  • 14. Liem BC, Truswell HJ, Harrast MA. Rehabilitation and return to running after lower limb stress fractures. Curr Sports Med Rep. 2013;12;200-7.
  • 15. Miller TL, Jamieson M, Everson S, et al. Expected time to return to athletic participation after stress fracture in division I collegiate athletes. Sports Health. 2018:10;340–4.
Medicine Science-Cover
  • ISSN: 2147-0634
  • Yayın Aralığı: 4
  • Başlangıç: 2012
  • Yayıncı: Effect Publishing Agency ( EPA )
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