Tuğba Raika KIRAN, Aysun KARABULUT BAY, İbrahim ŞAHİN, Cemil ÇOLAK

Evaluation of Oxidative Stress Status and Adenosine Deaminase Activity in Hyperthyroid and Hypothyroid Patients

A few prospective studies evaluated the oxidative stress variables and adenosine deaminase activity in patients with hyperthyroidism and hypothyroidism. Thus; we aimed to investigate oxidative stress variables and adenosine deaminase activity in patients with hyperthyroidism and hypothyroidism. Study populations consisted of 20 patients with hyperthyroidism, 20 patients with hypothyroidism and 20 age matched healthy volunteers as control group. Plasma nitric oxide, malondialdehyde levels and glutathione, adenosine deaminase activities were measured in all subjects. plasma nitric oxide and adenosine deaminase levels were higher in patients with hyperthyroidism, but lower in patients with hypothyroidism compared to those of controls (P<0.05). Plasma nitric oxide levels were higher in patients hypothyroidism compared to the control group (P<0.05). Glutathione levels were lower in both patients with hypo and hyperthyroidism compared to the control group (P<0.05). Our results suggest that both patients with hyperthyroidism and hypothyroidism may have effect on oxidative stress status and adenosine deaminase activity.

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