To investigate whether serum levels of inflammatory markers including high sensitive C-reactive protein (hs-CRP) and mean platelet volume (MPV) to platelet count ratio (MPR) were altered in patients with hyperemesis gravidarum (HEG) compared to asymptomatic pregnant women. Ninety pregnant women, 46 with HEG and the other 44 with healthy uncomplicated pregnancies were included the study. MPR was calculated as the MPV value to the platelet count obtained from the same blood sample. The clinical information and the laboratory results of the hematologic and biochemical parameters and hs-CRP levels of each participant were recorded. Platelet counts were didn’t differ between the groups. MPV, MPR and hs-CRP values were significantly higher in HEG group than in the control (p=0.01, p=0.05 and p=0.03, respectively). The etiopathogenesis of HEG is still obscure and its likely multi-factorial. Although we could not demonstrate the statistically significant differences in terms of platelet counts between the groups we found elevated levels of MPV, MPR and hs-CRP which conclude inflammatory basis of the disease.
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Niebyl JR. Nausea and vomiting in pregnancy. Clinical practice. N Engl J Med. 2010;363:1544-50.
Niemeijer MN, Grooten IJ, Vos N, et al. Diagnostic markers for hyperemesis gravidarum: a systematic review and metaanalysis. Am J Obstet Gynecol. 2014;211:150.e1-15.
Verberg MF, Gillott DJ, Al-Fardan N, et al. Hyperemesis gravidarum, a literature review. Hum Reprod Update. 2005;11:527-39.
Tayfur C, Burcu DC, Gulten O, et al. Association between platelet to lymphocyte ratio, plateletcrit and the presence and severity of hyperemesis gravidarum. J Obstet Gynaecol Res. 2017;43:498-504.
Caglayan EK, Engin-Ustun Y, Gocmen AY, et al. Is there any relationship between serum sirtuin-1 level and neutrophil-lymphocyte ratio in hyperemesis gravidarum? J Perinat Med. 2016;44:315-20.
Kurt RK, Güler A, Silfeler DB, et al. Relation of inflammatory markers with both presence and severity of hyperemesis gravidarum. Ginekol Pol. 2014;85:589-93.
Beyazit F, Öztürk FH, Pek E, et al. Evaluation of the hematologic system as a marker of subclinical inflammation in hyperemesis gravidarum: a case control study. Ginekol Pol. 2017;88:315-9.
Engin-Ustun Y, Tonguç E, Var T, et al. Vaspin and C-reactive protein levels in hyperemesis gravidarum. Eur Rev Med Pharmacol Sci. 2013;17:138-40.
Kırbaş Ö, Kurmuş Ö, Köseoğlu C, et al. Association between admission mean platelet volume and ST segment resolution after thrombolytic therapy for acute myocardial infarction. Anadolu Kardiyol Derg. 2014;14:728-32.
10. Oh GH, Chung SP, Park YS, et al. Mean platelet volume to platelet count ratio as a promising predictor of early mortality in severe sepsis. Shock. 2017;47:323-30.
11. Bellos I, Fitrou G, Pergialiotis V, et al. Mean platelet volume values in preeclampsia: A systematic review and meta-analysis. Pregnancy Hypertens. 2018l;13:174-80.
12. Djordjevic D, Rondovic G, Surbatovic M, et al. Neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume-to-platelet count ratio as biomarkers in critically Ill and injured patients: which ratio to choose to predict outcome and nature of bacteremia? Mediators Inflamm. 2018;2018:3758068.
13. Seckin B, Ates MC, Kirbas A, et al. Usefulness of hematological parameters for differential diagnosis of endometriomas in adolescents/young adults and older women.. Int J Adolesc Med Health. 2018;pii: /j/ijamh.ahead-of-print/ ijamh-2018-0078/ijamh-2018-0078.xml.
14. Shin DH, Rhee SY, Jeon HJ, Park JY, Kang SW, Oh J. An increase in mean platelet volume/platelet count ratio is associated with vascular access failure in hemodialysis patients. PLoS One. 2017;12:e0170357.
15. Yu T, Dong Y, Sun Z, et al. Comparison of prognostic significance of mean platelet volume/platelet count with GRACE for long-term prognosis in patients with non-ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention. Int J Cardiol. 2017;228:335-40.
16. Bessman JD, Williams LJ, Gilmer PR. Mean platelet volume. The inverse relation of platelet size and count in normal subjects, and an artifact of other particles. Am J Clin Pathol. 1981;76:289-93.
17. Kuscu NK, Yildirim Y, Koyuncu F, et al. Interleukin-6 levels in hyperemesis gravidarum. Arch Gynecol Obstet. 2003;269:13-5.
18. Gasparyan AY, Ayvazyan L, Mikhailidis DP, et al. Mean platelet volume: A link between thrombosis and inflammation? Curr Pharm Des. 2011;17:47-58.