Efficiency of mechanical thrombectomy in acute ischemic stroke patients

The aim of this single-center study is to assess the outcomes in patients with acute ischemic stroke underwent endovascular mechanical thrombectomy. The data and outcome of patients who were admitted due to acute ischemic stroke caused by a large vessel occlusion in the anterior or posterior circulation and treated with endovascular stent retriever mechanical thrombectomy between 2014 and 2018 were retrospectively evaluated. Recanalization success was assessed based on Thrombolysis in Cerebral Infarction (TICI) scores, and the TICI grades 2b and 3 were considered as ‘successful’. Functional outcomes of the patients were assessed by modified Rankin Scale (mRS) at the 3rd month follow up and a score of ≤2 points was considered as ‘good clinical outcome’. Successful recanalization was achieved in 34 patients (69%). At the 3rd month follow-up, 23 patients (46,9%) had mRS scores of ≤2 points. The overall mortality rate at the 90th day was %30 (n=15). After endovascular thrombectomy, symptomatic intracranial hemorrhage was seen in 9 patients, groin hematoma due to vascular access in 5 patients, which did not require additional treatment, and pseudoaneurysm in 3 patients. Stent retriever mechanical thrombectomy is an effective and safe procedure in patients admitted due to acute ischemic stroke caused by large vessel occlusion.

___

1. Rha JH, Saver JL. The impact of recanalization on iskemic stroke outcomes. Stroke. 2007;38:967-73.

2. Emberson J, Lees KR, Lyden P, et al. Effect of treatment delay, age and stroke severity on the effects of intravenous thrombolysis with alteplase for acut ischaemic stroke: a meta-analysis of individual patient data from randomized trials. Lancet. 2014,29;384:1929-35.

3. Bhatia R1, Hill MD, Shobha N, et al. Low rates of acute recanalization with intravenous recombinant tissue plasminogen activator in ischemic stroke: realworld experience and a call for action. Stroke. 2010;41:2254-8.

4. Riedel CH, Zimmermann P, Jensen-Kondering U, et al. The importance of size: successful recanalization by intravenous thrombolysis in acute anteriorstroke depends on thrombus length. Stroke. 2011;42:1775-7.

5. Kharitonova TV, Melo TP, Andersen G, et al. Importance of cerebral artery recanalization in patients with stroke with and without neurological improvement after intravenous thrombolysis. Stroke. 2013;44:2513-8.

6. Behme D, Mpotsaris A, Zeyen P, et al. Emergency stenting of the extracranial internal carotid artery in combination with anterior circulation thrombectomy in acute ischemic stroke: a retrospective multicenter study. AJNR Am J Neuroradiol. 2015;36:2340-5.

7. Berkhemer OA, Fransen PS, Beumer D, et al. A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med. 2015:1;372:11-20.

8. Goyal M, Demchuk AM, Menon BK, et al. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med. 2015 12; 372:1019-30.

9. Campbell BC, Mitchell PJ, Kleinig TJ, et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med. 2015; 372:1009-18.

10. Saver JL, Goyal M, Bonafe A, et al. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med. 2015;11;372:2285-95.

11. Jovin TG, Chamorro A, Cobo E, et al. Thrombectomy within 8 hours after symptom onset in ischemic stroke. N Engl J Med. 2015;11;372:2296-306.

12. Broderick JP, Palesch YY, Demchuk AM, et al. Endovascular therapy after intravenous t-PA versus t-PA alone skroke. N Engl J Med. 2013;7;368:893-903

13. Lees KR, Bluhmki E, von Kummer R, et al. Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet 2010;375:1695-703.

14. Zhu W, Churilov L, Campbell BC, et al. Large-Vessel Occlusion Is Associated with Poor Outcomes in Stroke Patient Aged 80 Years or Older Who Underwent Intravenous Trombolysis. J Stroke Cerebrovasc Dis. 2014;23:2888-93.

15. Vidale S, Agostoni E. Endovascular Treatment of ischemic stroke: an uptade meta-analyis of efficacy and safety. Vasc Endovascular Surg. 2017;51: 215-9.
Medicine Science-Cover
  • ISSN: 2147-0634
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2012
  • Yayıncı: Effect Publishing Agency ( EPA )
Sayıdaki Diğer Makaleler

Apelin hormone level and its role in the etiology of sudden hearing loss

Nuray ENSARİ, Özer Erdem GÜR, Nilgün GÜR, Ömer Tarık SELÇUK, Levent RENDA, M. Deniz YILMAZ, Hülya EYİGÖR, Yeşim ÇEKİN

Radiological and functional comparison of conservative and percutaneous methods in calcaneus fractures with severe soft tissue injury and edema

Ceyhun ÇAĞLAR, Fahri EMRE

Comparison of biochemical parameters of prevalent hemoglobinopathies with healthy individuals

Emrah YERLİKAYA, Hasan KARAGEÇİLİ, Mustafa Oğuzhan KAYA

Can ultrasound probes and gels be the source for opportunistic bacterial infections?

Özlem GENÇ, Sermin UMAY

Is the number of dislocations after bipolar hemiarthroplasty affected by anatomical parameters?

Erdal UZUN, Abdulhamit MİSİR

Efficiency of mechanical thrombectomy in acute ischemic stroke patients

Mehmet KOLU, İsmail Okan YILDIRIM, Ahmet Turan KAYA, Suat KAMIŞLI, Yüksel KAPLAN, Mehmet Akif DURAK, Şükrü GÜRBÜZ, Kaya SARAÇ

Is enoxaparin necessary to prevent adverse pregnancy outcomes in ethylenetetrahydrofolate reductase polymorphism positive recurrent pregnancy loss cases?

Hakan SAGER, Muhammed Emin SANCAK, Burcu DİNÇGEZ ÇAKMAK, Sonay ÖZTAŞ, Begüm UZSEZER, Ebru İnci ÇOŞKUN

Isolated left diaphragm metastasis of rectum adenocarcinoma

Mustafa YILDIRIM, Mustafa KOÇ

Phase value assessment reveals iron accumulation in parkinson disease

Ayşe Nur ŞİRİN ÖZCAN, Ebru Bilge DİRİK

Are clinical outcomes and failure rate following meniscal repair for vertical-longitudinal tears age-dependent

Erdal UZUN, Ahmet GÜNEY