RAİKAN BÜYÜKAVCI, SEMRA AKTÜRK, YÜKSEL ERSOY

Does Osteoporosis with Type 2 Diabetes Mellitus (Diabetoporosis) increase the risk of fracture?

Our aim was to investigate whether the association of diabetes and osteoporosis caused an increased risk of fracture or not. The study included 120 patients with osteoporosis aged between 40-90 years. Age, gender, body mass index (BMI), history of fracture and presence of Type 2 diabetes mellitus (T2DM) were recorded. 10-year major fracture and hip fracture risks were calculated with FRAX-WHO Fracture Risks Assessment Tool. Bone mineral density (BMD) measurements were made from femur neck and lumbar 1-4 vertebrae. All of the 120 patients included in the study, 21 were male and 99 were female. Twenty patients had T2DM diagnosis. The patient group with T2DM was older than the non-T2DM group in terms of mean age (p0.05). The number of patients with previous history of fracture was 24, and two of them were suffering from T2DM. In this study, Our results showed that osteoporosis with Type 2 Diabetes Mellitus may not significantly affect the fracture risk. The relationship between diabetes and bone metabolism should be screened in larger quantities, and T2DM should be positioned among the algorithms that assess the risk of fracture.

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Gokce Kutsal Y: Osteoporoz. In Fiziksel Tıp ve Rehabilitasyon Beyazova M, Gokce Kutsal Y, Eds. Ankara, Gunes Kitabevi Ltd Sti, 2000:1872-93.

Tuzun F, Akarırmak U, Dinc A: Osteoporozun Tanımı ve Sınıflandırılması. In Kemik ve Eklem Dekadında Osteoporoz Tuzun F, Akarırmak U, Dinc A, Eds. İstanbul, Aventis Pharma, 2002:9-13.

American Diabetes Association. Standards of medical care in diabetes 2014. Diabetes Care. 2014;37(1):14-80.

Ilhan Satman, Beyhan Omer, Yildiz Tutuncu, Sibel Kalaca, Selda Gedik, Nevin Dinccag Karsidag K, Genc S, Telci A, Canbaz B, Turker F, Yilmaz T, Cakir B, Tuomilehto J; TURDEP-II Study Group. Twelve-year trends in the prevalence and risk factors of diabetes and prediabetes in Turkish adults. Eur J Epidemiol. 2013;28(2):169-80.

https://www.sheffield.ac.uk/FRAX/tool.jsp

Osteoporosis prevention, diagnosis, and therapy. NIH Consens Statement. 2000;17(1):1-45.

Lewiecki EM, Borges JL. Bone density testing in clinical practice. Arq Bras Endocrinol Metabol. 2006;50(4):586-95.

Eryavuz Sarıdoğan M: Osteoporozun Tanımı ve Sınıflandırması. In Modern Tıp Seminerleri 19: Osteoporoz Gokce Kutsal Y, Ed. Ankara, Guneş Kitabevi Ltd. Şti.,2001:1-5.

Vestergaard P. Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes-a meta-analysis. Osteoporos Int. 2007;18(4):427-44.

Abdulameer SA, Sulaiman SA, Hassali MA, Subramaniam K, Sahib MN. Osteoporosis and type 2 diabetes mellitus: what do we know, and what we can do? Patient Prefer Adherence. 2012;6:435-48.

Melton LJ, Riggs BL, Leibson CL, Achenbach SJ, Camp JJ, Bouxsein ML, Atkinson EJ, Robb RA, Khosla S. A bone structural basis for fracture risk in diabetes. J Clin Endocrinol Metab. 2008;93(12):4804-9.

Bauer DC, Browner WS, Cauley JA, Orwoll ES, Scott JC, Black DM, Tao JL, Cummings SR. Factors associated with appendicular bone mass in older women. The Study of Osteoporotic Fractures Research Group. Ann Intern Med. 1993;118(9):657-65.

Tuominen JT, Impivaara O, Puukka P, Rönnemaa T. Bone mineral density in patients with type 1 and type 2 diabetes. Diabetes Care. 1999;22(7):1196-200.

Schacter GI, Leslie WD. DXA-Based measurements in diabetes: Can they predict fracture risk? Calcif Tissue Int. 2017;100(2):150-64.

Kanis JA, Johnell O, Oden A, Johansson H, McCloskey E. FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int. 2008;19(4):385-97.