Diffusion-weighted magnetic resonance imaging in diabetic retinopathy

Diabetic retinopathy (DR) is a complication of diabetes mellitus (DM) that may causes blindness. The vitreous is an extracellular matrix and it may have changes through liquefaction and syneresis in patients with DM, even in those without apparent DR. Diffusion-weighted imaging (DWI) is a new technique provide tissue contrast relying on difference with the diffusion of water molecules among tissues, which can be measured by the apparent diffusion coefficient (ADC) value. We aimed to investigate the vitreous of patients in different stages of DR using diffusion-weighted imaging technique. This prospective study included a group of 100 patients with DR and 100 members of an age- and gender-matched control group. All groups were tested using a head coil in conduction with a Achieva 1.5T magnetic resonans imaging (MRI) system (Philips Medical Systems, Best, The Netherlands). The mean ADC values were calculated and used for statistical comparisons. Mean duration of diabetes was 12.22±10.13 years in patients. Compared to controls, both eyes of the DR group had statistically and significantly lower values of ADC (p=0.025 and p=0.002, respectively). No significant correlations were found among the ADC values and central macular thickness, disease duration and stage of DR (all p>0.05) in patients. Mean ADC values revealed no significant differences among the subgroups of patients at different stages of DR (all p>0.05). Decreased ADCs in the vitreous of diabetes patients seem to be associated with the presence of diabetic retinopathy.

___

Nentwich MM, Ulbig MW. Diabetic retinopathy - ocular complications of diabetes mellitus. World J Diabetes. 2015;6(3):489-99.

Wu LM, Xu JR, Hua J, Gu HY, Chen J, Haacke EM, Hu J. Can diffusionweighted imaging be used as a reliable sequence in the detection of malignant pulmonery nodules and masses? Magn Reson Imaging. 2013;31(2):235-46.

Mannelli L, Nougaret S, Vargas HA, Do RK. Advances in Diffusion-Weighted Imaging. Radiol Clin North Am. 2015;53(3):569-81.

Bammer R. Basic principles of diffusion-weighted imaging. Eur J Radiol 2003; 45:169-184.

Le Bihan D, Breton E, Lallemand D, Aubin ML, Vignaud J, Laval-Jeantet M. Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology 1988;168(2):497-505.

Duong TQ, Pardue MT, Thule PM, Olson DE, Cheng H, Nair G, Li Y, Kim M, Zhang X, Shen Q. Layer-specific ana-tomical, physiological and functional MRI of the retina. NMR Biomed. 2008;21(9):978–96.

Spierer O, Ben Sira L, Leibovitch I, Kesler A. MRI demonstrates restricted diffusion in distal optic nerve in atypical optic neuritis. J Neuroophthalmol. 2010;30(1):31–3.

Nair G, Shen Q, Duong TQ. Relaxation time constants and apparent diffusion coefficients of rat retina at 7 Tesla. Int J Imaging Syst Technol. 2010;20:126–30.

Chen J, Wang Q, Zhang H, Yang X, Wang J, Berkowitz BA, Wickline SA, Song SK. In vivo quantification of T1, T2, and apparent diffusion coefficient in the mouse retina at 11.74T. Magn Reson Med. 2008;59(4):731–8.

Shen Q, Cheng H, Pardue MT, Chang TF, Nair G, Vo VT, Shonat RD, Duong TQ. Magnetic Resonance Imag-ing of Tissue and Vascular Layers in the Cat Retina. J Magn Reson Imaging. 2006;23(4):465–72.

Gao G, Li Y, Zhang D, Gee S, Crosson C, Ma J-X. Unbalanced expression of VEGF and PEDF in ischemia-induced retinal neovascularization. FEBS Lett. 2001;489(2-3):270–6.

Ogata N, Nishikawa M, Nishimura T, Mitsuma Y, Matsumura M. Unbalanced vitreous level of pigment epithelium derived factor in diabetic retinopathy. Am J Ophthalmol. 2002;134(3):348–53.

Duh E, Yang HS, Haller JA, De Juan E, Humayun MS, Gehlbach P, Melia M, Pieramici D, Harlan JB, Campochiaro PA, Zack DJ. Vitreous levels of pigment epithelium derived factor and vascular endothelial growth factor: implications for ocular angiogenesis. Am J Ophthalmol. 2004;137(4):668–74.

Cohen MP, Hud E, Shea E, Shearman CW. Vitreous fluid of db/db mice exhibits alterations in angiogenic and metabolic factors consistent with early diabetic retinopathy. Ophthalmic Res. 2008;40(1):5–9.

Dogan M, Ozsoy E, Doganay S, Burulday V, Firat PG, Ozer A, Alkan A. Brain diffusion-weighted imaging in diabetic patients with retinopathy. Eur Rev Med Pharmacol Sci. 2012;16(1):126-31.

Lu L, Sedor JR, Gulani V, Schelling JR, O’Brien A, Flask CA, MacRae Dell K. Use of diffusion tensor MRI to identify early changes in diabetic nephropathy. Am J Nephrol. 2011;34(5):476-82

Cakmak P, Yağcı AB, Dursun B, Herek D, Fenkçi SM. Renal diffusionweighted imaging in diabetic nephropathy: correlation with clinical stages of disease. Diagn Interv Radiol. 2014;20(5):374-8.

Tagawa H, McMeel JW, Furukawa H, Quiroz H, Murakami K, Takahashi M, Trempe CL. Role of the vitreous in diabetic retinopathy. I. Vitreous changes in diabetic retinopathy and in physiologic aging. Ophthalmology. 1986;93(5):596–601.

Foos RY, Krigger AE, Forsythe AB, Zakka KA. Posterior vitreous detachment in diabetic subjects. Ophthalmology. 1980;87(2):122–8.

Takahashi M, Trempe CL, Maguire K, McMeel JW. Vitreoretinal relationship in diabetic reti-nopathy: a biomicroscopic evaluation. Arch Ophthalmol. 1981;99(2):241–5.

Aiello LP, Avery RL, Arrigg PG, Keyt BA, Jampel HD, Shah ST, Pasquale LR, Thieme H, Iwamoto MA, Park JE. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med. 1994;331(22):1480-7.

Abu El-Asrar AM, Nawaz MI, Kangave D, Siddiquei MM, Ola MS, Opdenakker G. Angio-genesis regulatory factors in the vitreous from patients with proliferative diabetic retinopathy. Acta Diabetol. 2013;50(4):545-51.

Zhou J, Wang S, Xia X. Role of intravitreal inflammatory cytokines and angiogenic factors in proliferative diabetic retinopathy. Curr Eye Res 2012;37(5):416-20.

Abu El-Asrar AM, Nawaz MI, Kangave D, Abouammoh M, Mohammad G. High-mobility group box-1 and endothelial cell angiogenic markers in the vitreous from patients with prolif-erative diabetic retinopathy. Mediators Inflamm 2012;2012:697489.

Funatsu H, Yamashita H, Ikeda T, Mimura T, Eguchi S, Hori S. Vitreous levels of interleukin-6 and vascular endothelial growth factor are related to diabetic macular edema. Ophthalmolo-gy. 2003;110:690-6.

Wakabayashi Y, Usui Y, Okunuki Y, Kezuka T, Takeuchi M, Goto H, Iwasaki T. Correlation of vascular endothelial growth factor with chemokines in the vitreous in diabetic retinopathy. Retina. 2010;30(29:339-44.

Mohan N, Monickaraj F, Balasubramanyam M, Rema M, Mohan V. Imbalanced levels of an-giogenic and angiostatic factors in vitreous, plasma and postmortem retinal tissue of patients with proliferative diabetic retinopathy. J Diabetes Complications. 2012;26(5):435-41.

Watanabe D, Suzuma K, Suzuma I, Ohashi H, Ojima T, Kurimoto M, Murakami T, Kimura T, Takagi H. Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy. Am J Ophthalmol. 2005;139(3):476-81.
Medicine Science-Cover
  • ISSN: 2147-0634
  • Yayın Aralığı: Yılda 4 Sayı
  • Başlangıç: 2012
  • Yayıncı: Effect Publishing Agency ( EPA )
Sayıdaki Diğer Makaleler

Safety and efficacy of combination therapy (Simeprevir/Sofosbuvir) in the treatment of chronic HCV genotype IV patients

Engy A WAHSH, Amal K. HUSSEİN, Ahmed A. GOMAA, Mohamed A. BARAKA, Mohie Al-deen ABEAD

Relationship between living arrangements, quality of life and depressive symptoms of older adults

Hatice YİĞEN, Osman GÜNAY, ARDA BORLU

Efficacy of perianal nerve blockfor day care ano-rectal procedures

Manoj Kumar SHARMA, Ashish VADHERA, Madhusudan DEY, Gouriprasad KURUMAPU

Effects of enteral and total parenteral nutrition on length of stay in intensive care unit in postoperative period

MUSTAFA SAİD AYDOĞAN, RAMAZAN PAŞAHAN, Ali KARADEMİR, AYTAÇ YÜCEL, Buğra KARAKAŞ, Türkan TOĞAL

An examination of factors affecting the length of stay in long-term intensive care

METİN DİNÇER, Kadriye KAHVECİ, Cihan DÖĞER

Vildagliptin induced cutaneous leukocytoclastic vasculitis: A case report

Serhat SAYIN, Ethem ÖMEROĞLU, Semra ASLAN BİLGİN

Is the change in platelet parameters in children with allergic rhinitis an indicator of allergic inflammation?

Erdem TOPAL, Mehmet Halil ÇELİKSOY, FİLİZ DEMİR, HARİKA GÖZDE GÖZÜKARA BAĞ, RECEP SANCAK

Osteogenesis imperfecta and attention deficit hyperactivity disorder: A rare combination

ALİ KARAYAĞMURLU, Elif KARAYAĞMURLU, Cem GÖKÇEN

An investigation of infection rate and seasonal effect level in total joint replacement cases

REŞİT SEVİMLİ, Okan ASLANTÜRK, KADİR ERTEM, Ahmet HARMA, Gökay GÖRMELİ, AYDIN ARSLAN

A fatal Acremonium falciforme peritonitis

Yasemin Ay ALTINTOP, Ayşe NEDRET KOÇ