Preeclampsia is a multisystem disorder characterized by new-onset hypertension and proteinuria after 20 weeks of gestation. The association between androgens and hypertension has been demonstrated. The purpose of this study was to determine the relationship between androgen levels and fetal and maternal complications in patients with preeclampsia. This study included 178 patients who were followed up with the diagnosis of preeclampsia and gave birth in High-Risk Pregnancy Clinic of Zekai Tahir Burak Women’s Health Research and Education Hospital. Androstenedione, dehydroepiandrosterone sulfate, total testosterone and free testosterone levels were measured by the Immulite 200 chemiluminescence method on the BioDPC Isodata 100 Series Gamma Counter in venous blood samples. Maternal complications and fetal complications were recorded. The relationship between these complications and androgen levels was examined. Free testosterone levels were significantly higher in those with a 1-min Apgar score
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Brown MA, Lindheimer MD, de Swiet M, et al. The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP). Hypertens Pregnancy 2001;20:IX–XIV.
Sibai BM, Gordon T, Thom E, et al. Risk factors for preeclampsia in healthy nulliparous women: a prospective multicenter study. The National Institute of Child Health and Human Development Network of Maternal–Fetal Medicine Units. Am J Obstet Gynecol. 1995;172:642–8.
Duley L. Maternal mortality associated with hypertensive disorders of pregnancy in Africa, Asia, Latin America and the Caribbean. Br J Obstet Gynaecol. 1992;99:547-53.
Perez-Sepulveda A, Torres MJ, Khoury M, Illanes SE. Innate immune system and preeclampsia. Front Immunol. 2014;26:244.
5 Redman CW, Sargent IL. Immunology of pre-eclampsia. Am J Reprod Immunol. 2010;63:534–543.
6 Hsu P, Santner-Nanan B, Dahlstrom JE, et al. Altered decidual DCSIGN+ Antigen-Presenting cells and impaired regulatory T-cell induction in Preeclampsia. Am J Pathol. 2012;94:2149–60.
7 Hertig A, Liere P, Chabbert-Buffet N, et al. Steroid profiling in preeclamptic women: evidence for aromatase deficiency. Am J Obstet Gynecol. 2010;477:e1–9.
American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy.Obstet Gynecol. 2013;122:1122-31.
Al Khaja KA, Sequeira RP, Alkhaja AK, Damanhori AH. Drug treatment of hypertension in pregnancy: a critical review of adult guideline recommendations. J Hypertens. 2014;32:454-63.
Baker PJ, Ramey ER, Ramwell PW. Androgen-mediated sex differences of cardiovascular responses in rats. Am J Physiol. 1978;235:H242-6.
Bachmann J, Feldmer M, Ganten U, Stock G, Ganten G. Sexual dimorphism of blood pressure: possible role of the renin-angiotensin system. J Steroid Biochem Mol Biol. 1991;40:511-5.
Acromite MT, Mantzoros CS, Leach RE, et al. Androgens in preeclampsia. Am J Obstet Gynecol. 1999;180:60-3.
Correa PJ, Palmeiro Y, Soto MJ, et al. Etiopathogenesis, prediction, and prevention of preeclampsia. Hypertens Pregnancy. 2016;35:280-94.
Jobe SO, Tyler CT, Magness RR, Aberrant synthesis, metabolism, and plasma accumulation of circulating estrogens and estrogen metabolites in preeclampsi implications for vascular dysfunction, Hypertension. 2013;61:480–7.
Berkane N, Liere P, Oudinet JP, et al. From pregnancy to preeclampsia: a key role for estrogens. Endocr Rev. 2017;38:123–44.
16. Harmon QE, Huang L, Umbach DM, et al. Risk of fetal death with preeclampsia. Obstet Gynecol. 2015;125:628-35.
17. Barbosa IR, Silva WB, Cerqueira GS, et al. Maternal and fetal outcome in women with hypertensive disorders of pregnancy: the impact of prenatal care. Ther Adv Cardiovasc Dis. 2015;9:140-6.
18. Haram K, Svendsen E, Abildgaard U. The HELLP syndrome: clinical issues and management. A review. BMC Pregnancy and Childbirth. 2009; 9:8.
19. van Dam PA, Renier M, Baekelandt M, et al. Disseminated intravascular coagulation and the syndrome of hemolysis, elevated liver enzymes, and low platelets in severe preeclampsia. Obstet Gynecol. 1989;73:97–102
20. Osmanagaoglu MA, Osmanagaoglu S, Ulusoy H, Bozkaya H. Maternal outcome in HELLP syndrome requiring intensive care management in a Turkish hospital. Sao Paulo Med J. 2006;124:85–9
21. Salamalekis E, Bakas P, Vitoratos N, et al. Androgen levels in the third trimester of pregnancy in patients with preeclampsia. Eur J Obstet Gynecol Reprod Biol. 2006;126:16-9.
22. Gerulewicz-Vannini D, Camero Y, Salas J, et al..High plasmatic androgen levels in women affected with pregnancy-induced hypertension. Rev Invest Clin. 2006;58:228-33.
23. Zeisler H, Sator MO, Joura EA. Serum levels of progesterone in patients with preeclampsia. Wien Klin Wochenschr. 2000;112:362-4.
24. Manikkam M, Crespi EJ, Doop DD, et al. Fetal programming: prenatal testosterone excess leads to fetal growth retardation and postnatal catch-up growth in sheep. Endocrinology. 2004;145:790–8.