Bambang SETİAWAN, Asnawati DARSUNİ, Fauzan MUTTAQİEN, M Aris WİDODO

Cholesterol Lowering Effect of Subchronic Inhalation Particulate Matter 10 Coal Dust on Rats

Aim of this study was have to known an effect of inhaled particulate matter 10 (PM10) of coal dust on lipid profile, hematopoetic stem cells (HSC) and circulating endothelial cells (CECs) in rats. A total of 32 Wistar male rats, were randomly divided into four groups of 8 rats each, including one control group and three groups for inhaled coal dust (concentration 6.25 mg/m3; 12.5 mg/m3; and 25 mg/m3). The exposure to coal dust exposure was conducted using equipment that was designed by and available from Pharmacology Laboratory, Medical Faculty, Brawijaya University of Malang. The level of total cholesterol was lower significantly in rats inhaled to coal dust at compared with the control rats (p<0.05). The level of triglycerydes was higher significantly in rats inhaled to coal dust at concentration 25 mg/m3 compared with the control rats (p<0.05). The level of LDL-c was lower significantly in rats inhaled to coal dust at concentration 12.5 and 25 mg/m3 compared with the control rats (p<0.05), but the level of HDL-c, HSCs and CECs were not different significantly (p>0.05). The level of HDL-c/LDL-c ratio was higher significantly in rats inhaled to coal dust at concentration 12.5 and 25 mg/m3 compared with the control rats (p<0.05). The level of cholesterol/HDL-c ratio and atherogenic index were lower significantly in rats inhaled to coal dust at concentration 12.5 and 25 mg/m3 compared with the control rats (p<0.05). The level of hematopoetic stem cells and circulating endothelial cells were not different significantly in rats inhaled to coal dust compared with the control rats (p>0.05). Sub-chronic inhalation particulate matter 10 (PM10) coal dust have lowering effect on atherogenic index due to decreasing cholesterol and LDL levels. Beside that, sub-chronic inhalation particulate matter 10 (PM10) coal dust also have dyslipidemia which marked by increasing of triglyceride levels.

Anahtar Kelimeler:

dyslipidemia; inhaled pollution; endothelial damage; hematopoetic stem cells

Cholesterol Lowering Effect of Subchronic Inhalation Particulate Matter 10 Coal Dust on Rats

Keywords:

dyslipidemia; inhaled pollution; endothelial damage; hematopoetic stem cells,

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