Postoperative sore throat is usually accepted as a minor complication, however it contributes to patient dissatisfaction. The primary aim of this study is to compare the effects of two different therapies for postoperative sore throat. The secondary aim is to determine the correlation of smoking and postoperative sore throat via visual analogue scale scores. The patients diagnosed as “postoperative sore throat” were detected from hospital database. The files of the patients with severe sore throat after tracheal intubation for laparoscopic cholecystectomy, were analyzed retrospectively. The patients treated with either benzydamine or ketamine gargle were included into the study. Age, sex and smoking habits, visual analogue scale scores at the 1st, 24th and 48th hour and the chosen therapy were recorded according to nurse care records.122 patients were included into the study. There were no significant differences for age, sex, smoking habits and visual analogue scale scores in the postoperative first hour among the therapy groups. Mean visual analogue scale was 2.8±0.83 in ketamine group and 3.3±0.99 in benzydamine group at the postoperative 24th hour (p < 0.05). At postoperative 48th hour, it was 1.06±0.756 in ketamine group and 1.5±0.718 in the benzydamine group (p < 0.05), At all time points, mean visual analogue scale were similar among smoking and non-smoking patients (p > 0.05). In this study, the ketamine gargle was more effective than the benzydamine gargle for attenuation of postoperative sore throat. Moreover, no significant effects of smoking were detected with regard to the POST incidence.
Agarwal A, Nath SS, Goswami D, et al. An evaluation of the efficacy of aspirin and benzydamine hydrochloride gargle for attenuating postoperative sore throat: a prospective randomized, single-blind study. Anesth Analg. 2006;103:10001-3.
Biro P, Seifert B, Pasch T. Complaints of sore throat after tracheal intubation: a prospective evaluation. Eur J Anaesthesiol. 2005;22:307-11.
Hae Gyun Park, Jung Sik Im, Jeoung Sun Park. et al. A comparative evaluation of humidifier with heated wire breathing circuit under general anesthesia. Korean journal of anesthesiology. 2009;57:32-7.
Zuccherelli L. Postoperative upper airway problems. South Afr J Anaesth Analg. 2003;9:12-6.
Al-Qahtani AS MF. Quality improvement in anesthetic practice--incidence of sore throat after using small tracheal tube. Middle East J Anesthesiol. 2005;18:179-83.
El-Boghdadly K, Bailey CR, Wiles MD. Postoperative sore throat: a systematic review. Anaesthesia. 2016;71:706-17.
Hung NK, Wu CT, Chan SM, et al. Effect on postoperative sore throat of spraying the endotracheal tube cuff with benzydamine hydrochloride, 10% lidocaine, and 2% lidocaine. Anesth Analg. 2010;111:882-6.
Huang YS, Hung NK, Lee MS, et al. The effectiveness of benzydamine hydrochloride spraying on the endotracheal tube cuff or oral mucosa for postoperative sore throat. Anesth Analg. 2010;111:887-91.
Neder Meyer T, Lazaro Da Slva A. Ketamine reduces mortality of severely burnt rats, when compared to midazolam plus fentanyl. Burns. 2004;30:425-30.
Zhu MM, Qian YN, Zhu W, et al. Protective effects of ketamine on allergeninduced airway inflammatory injure and high airway reactivity in asthma: experiment with rats. Zhonghua Yi Xue Za Zhi. 2007;87:1308-13.
Canbay O, Celebi N, Sahin A, et al. Ketamine gargle for attenuating postoperative sore throat. British journal of anaesthesia. 2008;100:490-3.
Oatway M, Reid A, Sawynok J. Peripheral antihyperalgesic and analgesic actions of ketamine and amitriptyline in a model of mild thermal injury in the rat Anesthesia and analgesia. 2003;97:168-73.
Luppi F, Aarbiou J, van Wetering S, et al. Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: role of glutathione. Respir Res. 2005;6:140.
Şanlı A, Bekmez E, Yıldız G, et al. Relationship between smoking and otorhinolaryngological symptoms. Kulak Burun Bogaz Ihtis Derg. 2016;26:28-33.