Analysis of the correlation between thyroid hormones and thyroid volume by gender: A volumetric computed tomography study
Analysis of the correlation between thyroid hormones and thyroid volume by gender: A volumetric computed tomography study
The aim of this study was to evaluate the correlation between triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) hormones and thyroid gland volume with volumetric analysis performed by using computed tomography (CT) images. In this retrospective study, IV contrasted thoracic CT images taken for different indications between 2019 January and 2020 January were scanned from the archive system of the hospital. 67 (31F, 36M) individuals chosen randomly among patients whose CT results were reported as normal and who had taken thyroid hormone tests within the past week were included in the study. Images in Digital Imaging and Communications in Medicine format were transferred to the personal work station program (Horos Medical Image Viewer). By using the Region of Interest (ROI) console in the current program, a three dimensional model was obtained by drawing the border of the thyroid gland in sections varying between 15 and 25. Volume values of this three-dimensional model and TSH, T3, T4 values of the individuals were compared. While no correlation was found between thyroid gland volume and T3 and T4 hormones, a negative significant correlation was found with TSH. In terms of gender, thyroid gland volume, T3, T4 values were found to be statistically significantly higher in women when compared with men (p≤0.05). TSH value was found to be higher in women when compared with men (p=0.005). No statistically significant difference was found in T4 value (p=0.057). Radio-anatomical volumetric data of the thyroid gland presented in this study and its correlation with thyroid functions will be beneficial to clinicians working in the field in both internal and surgical medicine branches and will also guide future studies.
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- 1. Prabhu SR, Mahadevan S, Jagadeesh S, et al. Normative data of thyroid gland volume in south indian neonates and infants. Indian J Pediatr. 2018;85:1045-9.
- 2. Lee D-H, Cho K-J, Sun D-I, et al. Thyroid dimensions of Korean adults on routine neck computed tomography and its relationship to age, sex, and body size. Surg Radiol Anat. 2006;28:25-32.
- 3. Henjum S, Strand TA, Torheim LE, et al. Data quality and practical challenges of thyroid volume assessment by ultrasound under field conditions - observer errors may affect prevalence estimates of goitre. Nutr J. 2010;9:66.
- 4. Zimmermann M, Saad A, Hess S, Torresani T, Chaouki N. Thyroid ultrasound compared with World Health Organization 1960 and 1994 palpation criteria for determination of goiter prevalence in regions of mild and severe iodine deficiency. Eur J Endocrinol. 2000;143(6):727-31.
- 5. Mindel S. Role of imager in developing world. Lancet. 1997;350:426-9.
- 6. Parks NA, Schroeppel TJ. Update on imaging for acute appendicitis. Surg Clin North Am. 2011;91:141-54.
- 7. Pepper VK, Stanfill AB, Pearl RH. Diagnosis and management of pediatric appendicitis, intussusception, and Meckel diverticulum. Surg Clin North Am. 2012;92:505-26.
- 8. Rotondi M, Magri F, Chiovato L. Thyroid and obesity: not a one-way interaction. J Clin Endocrinol Metab. 2011;96:344-6.
- 9. Witkowska-Sedek E, Kucharska A, Ruminska M, Pyrzak B. Thyroid dysfunction in obese and overweight children. Endokrynol Pol. 2017;68:54- 60.
- 10. Chang C-Y, Hong Y-C, Tseng C-h. A neural network for thyroid segmentation and volume estimation in CT images. IEEE Trans Biomed Eng. 2011;6:43-55.
- 11. Hermans R, Bouillon R, Laga K, et al. Estimation of thyroid gland volume by spiral computed tomography. European Radiol. 1997;7:214-6.
- 12. Wang H, Chen F, Zhang Y, et al. Three-dimensional reconstruction of cervical CT vs ultrasound for estimating residual thyroid volume. Nan Fang Yi Ke Da Xue Xue Bao. 2019;39:373-6.
- 13. Gerber D. Thyroid weights and iodized salt prophylaxis: a comparative study from autopsy material from the Institute of Pathology, University of Zurich. Schweiz Med Wochenschr. 1980;110:2010-7.
- 14. Langer P. Discussion about the limit between normal thyroid and goiter: Minireview. Endocr Regul. 1999;33:39-45.
- 15. Karabeyoglu M, Unal B, Dirican A, et al. The relation between preoperative ultrasonographic thyroid volume analysis and thyroidectomy complications. Endocr Regul. 2009;43:83-7.
- 16. Carlé A, Pedersen IB, Knudsen N, et al. Thyroid volume in hypothyroidism due to autoimmune disease follows a unimodal distribution: evidence against primary thyroid atrophy and autoimmune thyroiditis being distinct diseases. J Clin Endocrinol Metab. 2009;94:833-9.
- 17. Hegedüs L. Thyroid size determined by ultrasound. Influence of physiological factors and non-thyroidal disease. Dan Med Bull. 1990;37:249-63.