Metin ERTEM, Emel ÖZVERİ, Deniz Esin TEKCAN ŞANLI, Şafak KIZILTAŞ, Serpil YILMAZ, Ahmet Necati ŞANLI

Acute enteric eosinophilic myenteric ganglionitis: A challenging and uncommon case of lung adenocarcinoma

Chronic intestinal pseudo-obstruction (CIPO) is caused by metabolic and endocrine factors, but it can also be caused by the cancer's paraneoplastic effect. The cancers most associated with paraneoplastic syndromes are lung cancers and are generally associated with small cell lung cancers. Lung adenocarcinomas may rarely cause paraneoplastic syndromes, however, they mostly cause general effects such as cachexia and leukocytosis. The goal of this case report was to provide a case of non-mechanical obstruction due to lung adenocarcinoma as a very unusual cause of intestinal pseudo-obstruction, together with clinical, laboratory, and imaging results.

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1. Ahmed S, Sharman T. Intestinal Pseudo-Obstruction. 2020 Oct 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 32809504.
2. Lee H, Kang D, Kim H, et al. Unusual Histology of Eosinophilic Myenteric Ganglionitis: A Case Report. J Pathol Transl Med. 2017;51:320-4.
3. Antonucci A, Fronzoni L, Cogliandro L, et al. VChronic intestinal pseudoobstruction. World J Gastroentero. 2008;14:2953-61.
4. Kanaji N, Watanabe N, Kita N, et al. Paraneoplastic syndromes associated with lung cancer. World J Clin Oncol. 2014;5:197-223.
5. Downes TJ, Cheruvu MS, Karunaratne TB, wt al. Pathophysiology, Diagnosis, and Management of Chronic Intestinal Pseudo-Obstruction. J Clin Gastroenterol. 2018;52:477-89.
6. Schäppi MG, Smith VV, Milla PJ, Lindley KJ. Eosinophilic myenteric ganglionitis is associated with functional intestinal obstruction. Gut. 2003;52:752-5.
7. De Giorgio R, Cogliandro RF, Barbara G, et al. Chronic intestinal pseudoobstruction: clinical features, diagnosis, and therapy. Gastroenterol Clin North Am. 2011;40:787-807.
8. Stanghellini V, Cogliandro RF, Giorgio R, et al. (2007) Chronic intestinal pseudo-obstruction: manifestations, natural history and management. Neurogastroenterol Motil. 2007;19:440-52.
9. Sekino Y, Inamori M, Yamada E, et al. Characteristics of intestinal pseudoobstruction in patients with mitochondrial diseases. World J Gastroenterol. 2012;18:4557-62.